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BMJ Case Rep. 2010; 2010: bcr09.2009.2296.
Published online Jan 13, 2010. doi:  10.1136/bcr.09.2009.2296
PMCID: PMC3029874
Rare disease
Wegener’s granulomatosis in pregnancy: a case report and review of the medical literature
Vinodh Nanjanna Devakumar,1,2 Madhura Castelino,3 Shien-Ching Chow,4 and Lee-Suan Teh4
1The Royal Oldham Hospital, Rheumatology and Medicine, K Block, Rochdale Road, Oldham, OL1 2JH, UK
2Kendal Drive, Gatley, Cheadle, Cheshire SK84QJ, UK
3Royal Blackburn Hospital, Rheumatology, Rheumatology Department, Blackburn BB2 3HH, UK
4Royal Blackburn Hospital, Department of Rheumatology, Haslingden Road, Blackburn BB2 3HH, UK
Correspondence to Madhura Castelino, castelinom/at/gmail.com
Abstract
A Caucasian woman in the third trimester of her sixth pregnancy was diagnosed with Wegener’s granulomatosis (WG) following investigation for recurrent ear infections and a persistent dry cough. Chest radiograph showed granulomatous lesions and the c-ANCA (antineutrophil cytoplasmic antibody) was strongly positive. She required pulsed methylprednisolone and cyclophosphamide followed by oral prednisolone and azathioprine to control the disease process during and after pregnancy. Neither the disease nor aggressive treatment adversely affected the pregnancy and she delivered a healthy baby girl by elective induction at 37 weeks. A review of the literature on Wegener’s granulomatosis in pregnancy is presented.
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