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Logo of bmjcrInstructions for authorsCurrent ToCBMJ Case Reports
BMJ Case Rep. 2010; 2010: bcr0120102659.
Published online Sep 7, 2010. doi:  10.1136/bcr.01.2010.2659
PMCID: PMC3029542
Unusual association of diseases/symptoms
Cerebrospinal fluid leak associated with nasal continuous positive airway pressure treatment for obstructive sleep apnoea
Jean Yared1 and Jaafar El Annan2
1Department of Internal Medicine, Greater Baltimore Medical Center, Towson, Maryland, USA
2Department of Ophthalmology, University of Louisville, Louisville, Kentucky, USA
Correspondence to Jean Yared, jeanyared/at/
Clear rhinorrhoea is a common symptom in patients with obstructive sleep apnoea (OSA), which may worsen with nasal continuous positive airway pressure treatment (nCPAP). However, rhinorrhoea can also be the presenting symptom of cerebrospinal fluid (CSF) leak, which is due to a communication between the subarachnoid space and the nasal cavity or sinuses. We report another case of a patient with OSA in whom CSF leak developed following the initiation of nCPAP treatment.
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