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BMJ Case Rep. 2010; 2010: bcr07.2009.2126.
Published online 2010 January 13. doi:  10.1136/bcr.07.2009.2126
PMCID: PMC3028432
Reminder of important clinical lesson
Abdominal abscess due to retained gallstones 5 years after laparoscopic cholecystectomy
Amir Awwad, Keith Mulholland, and Barry Clements
Royal Victoria Hospital, General Surgery, Belfast, Co Fermanagh BT12, UK
Correspondence to Amir Awwad, amirawwad/at/hotmail.com
A 76-year-old female patient with diabetes presented with pyrexia and a recurrent painful right sided loin swelling. One year previously she had undergone radiological drainage of a large right sided loin abscess. At index presentation she was investigated both radiologically and endoscopically and a source for the abscess was not found. On this presentation, a computed tomography scan confirmed a large retroperitoneal abscess pointing through the lateral abdominal wall musculature. Surgical drainage was undertaken whereby the abscess was drained and several large gallstones extruded through the incision. The patient subsequently recuperated and the wound has healed successfully by second intention. Five years previously the patient had undergone an “uncomplicated” laparoscopic cholecystectomy. This case highlights the catastrophic late effects of dropped gallstones during laparoscopic cholecystectomy.
Background
This report describes a rare but significant complication of laparoscopic cholecystectomy (LC). Gallstones are extremely common and LC is one of the most common surgical procedures. It is not uncommon for gallstones to be spilled and there is a general acceptance that this event is of little clinical significance. It is very important to try and avoid such contamination during LC. Should such an eventuality occur, retrieval of the spilled stones should be meticulous and the event recorded in the operation notes. One should be vigilant and cognisant of potential complications when stones are spilled.
A 76-year-old woman with non-insulin dependent diabetes presented with a 2 week history of fever, rigors, night sweats and an increasingly painful right sided loin mass. On examination she was pyrexic (37.8°C) with a large brawny fluctuant swelling in the right loin suggestive of an abscess.
A smaller abscess had been drained radiologically from the same site 1 year previously. At that time investigations including colonoscopy, oesophagogastroduodenoscopy (OGD) and renal ultrasonography failed to identify the source. Relevant past medical history included type II diabetes mellitus, osteoarthritis necessitating a total right hip replacement 20 years previously, and an elective LC 5 years previously.
Investigations
Bloods: Haemoglobin 10.5 mg/dl, white blood cell count 17.9×109/ml, neutrophilia 15.7×109/ml, C reactive protein 240 mg/dl.
Computed tomography (CT) scan: Huge right flank abscess (17×10 cm) with air fluid collection in the right retro-peritoneal space extending through the muscles of the lateral abdominal wall into the soft tissues in the region of the Grynfeltt’s triangle (fig 1). No obvious aetiology was identifiable.
Figure 1
Figure 1
Computed tomography scan of abdomen showing large retroperitoneal abscess extending to subcutaneous tissue in right loin.
Differential diagnosis
Renal or gastrointestinal sepsis would be most commonly culpable for this presentation—that is, appendicitis, solitary caecal diverticulitis, diverticular disease, perforated caecal tumour or perinephric abscess secondary to pyelonephritis. One should also be cognisant of opportunistic infection in susceptible patients, such as fungal infection and tuberculosis.
Treatment
Incision and drainage of the abscess in the left lateral position under general anaesthesia was undertaken. A total of 550 ml of frank, foul smelling pus was drained, and an incidental finding of several gallstones in the cavity identified (fig 2). The cavity was lavaged copiously, swabs were taken for bacteriological assessment, and a drain was left in situ. Broad spectrum intravenous antibiotic treatment was initiated pending cultures.
Figure 2
Figure 2
Multiple gallstones extracted from the abscess cavity.
Outcome and follow-up
The bacteriological culture revealed Escherichia coli species. The patient responded well to treatment. The drain was removed after 24 h. Concomitantly the patient’s white blood cell count and C reactive protein values returned to normal and the patient was discharged on the fourth postoperative day. The patient was entirely well at outpatient review 6 weeks later, and the wound had healed by second intention in an uncomplicated fashion.
Almost 22 years have elapsed since the introduction of LC in 1987. With the evolution of the laparoscopic approach, injury to the biliary tree is recognised as the most serious complication and as such has received most attention by the surgical and legal fraternity.9 Other idiosyncratic complications have come to light and the effects of gallbladder perforation with stone spillage is one which is recognised as producing sporadic but significant morbidity. A literature review revealed only 14 case reports described this rare complication of spilled gallstones leading to abdominal wall abscesses.18
This case report describes the recurrence of an abdominal wall abscess due to gallstones spilled in the abdominal cavity 5 years previously at the time of an elective LC. The cause of the abscess was not apparent upon investigation at the index presentation 1 year previously, highlighting the difficulty in diagnosis of this clinical entity. Again on this admission the CT scan showed the magnitude of this large abscess but did not elude to the aetiology. This was only apparent upon surgical drainage of the abscess. One might speculate that had a radiological approach been adopted again the precipitating aetiology might not have come to light. The incidence of bacterobilia in the presence of gallstones is in the order of 30%.9 Prophylactic antibiotics are routinely employed at the time of LC although the benefit that this bestows is hard to quantify as this prophylactic measure is a legacy from the era of open cholecystectomy where its inherent wound risks were frequently problematic.
This complication has an approximate incidence of 0.3% and may occur within 6 months up to 11 years post LC. Abscess formation can be sporadic and variable in its presentation with the capacity for abscess development at remote and diverse sites (intraperitoneal 44.1%, abdominal wall abscess 18.1%, thoracic abscess 11.8%, retroperitoneal abscess, 10.2%). Other stones with concomitant abscess formation have been described at trocar sites and/or within incisional hernias.10
Zehetner et al conducted a systematic literature review between January 1987 and January 2005 to conclude that although spilled gallstones may have a low incidence of complications, these complications can present in a large variety of problems later on. Without any need to open conversion, the study suggested laparoscopic techniques to remove spilled stones intraoperatively, highlighted the importance of documentation in the operation notes, as well as the role of interventional drainage postoperatively and in late complications.11
This case report highlights the significance of spilled gallstones during LC. It demonstrates the importance of having contingency plans for such an eventuality intraoperatively and the importance of being aware of this complications and the time frame for its development. By way of reflective practice it is important to take steps to minimise this complication and to record its occurrence accurately at the time of surgery, so that those following on might have the best opportunity to recognise and treat this complication expediently.
Learning points
  • Attempts should be made to avoid gallbladder perforation and remove spilled gallstones; thereby complications could be minimised or prevented.
  • Spilled gallstones should be documented in the operative notes.
  • CT scanning has a low sensitivity for demonstrating gallstones and may be of limited value in diagnosing complications secondary to spilled stones.
  • There should be improved training for laparoscopic cholecystectomy and for adopting a safe strategy for gallbladder removal (retrieval bags) and peritoneal salvage of spilled stones should this occur (pelican forceps).
  • Although this is a rare complication, laparoscopic cholecystectomy is a common operation and gallstone spillage is also common. The morbidity from spilled stones is difficult to quantify; however, case reports are common and morbidity significant.
  • This report highlights the importance of trying to avoid this eventuality and trying to remedy the situation should it occur. One must accurately record this eventuality in the notes for future reference as complications may be delayed.
Footnotes
Competing interests: None.
Patient consent: Patient/guardian consent was obtained for publication.
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