Over the years, antibiotics have revolutionised the management of CST. However, despite early diagnosis and aggressive management, current mortality is still around 20–30%. In patients who recover, long-term sequelae occur in up to 22%.1
These include unilateral blindness, decreased visual acuity and hemiparesis. Management of CST involves dealing with the primary focus of infection such as sinusitis, dental abscess or facial cellulitis. Treatment should also be directed towards specific complications, for example, meningitis, intracranial abscess, subdural empyema, etc. The vast majority of cases are initially treated with a combination of a third generation cephalosporin, flucloxacillin and metronidazole.2
Although there are no standards for the duration of antibiotic therapy, it is recommended that antibiotics should be given for at least 2 weeks beyond the clinical resolution of symptoms. This is due to the assumption that bacteria within thrombi may not be eradicated until the venous sinuses canalise.3 4
In cases where specific culture results are available, antibiotics should be modified accordingly.
Due to the rarity of this condition, there does not appear to be a consensus on the use of anticoagulant therapy in CST. However, a systematic review of case series on the use of anticoagulants showed a favourable outcome in those treated with anticoagulants and it was reported that anticoagulant therapy should be considered for cases of CST with no signs of haemorrhagic intracranial complications.5
Anticoagulant therapy appears to be particularly useful in reducing diplopia associated with cranial nerve involvement and neurological sequelae such as seizures, hemiparesis or hypopituitarism.
Direct surgical drainage of the cavernous sinus is virtually never performed and operative intervention for CST is usually directed towards the primary source of infection. In cases of a sinogenic cause of CST, drainage of sinuses should be performed promptly. Following the acute phase of infection, recovery is gradual and up to 50% of patients can have long-term neurological deficits in the form of decreased visual acuity, diplopia, cranial nerve deficits, hemiparesis, ataxia or epilepsy. The majority of reported cranial nerve deficits have involved the occulomotor and abducens nerves. Long-term follow-up of these patients is essential as relapses have been reported after apparent clinical resolution.6
- Cavernous sinus thrombosis (CST) is a rare but potentially life threatening condition.
- It has high mortality and morbidity rates (30% and 50%, respectively).
- Knowledge of the ocular manifestations of CST is essential to differentiate it from other causes of periorbital swelling.
- Long-term parenteral antibiotic therapy is the mainstay of treatment, with anticoagulation for cases with no haemorrhagic intracranial complications.