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BMJ Case Rep. 2010; 2010: bcr0620103094.
Published online 2010 October 21. doi:  10.1136/bcr.06.2010.3094
PMCID: PMC3028091
Unexpected outcome (positive or negative) including adverse drug reactions

Angioneurotic orolingual oedema following thrombolysis in acute ischaemic stroke


Alteplase used for thrombolysis in ischaemic stroke may be complicated by orolingual acute angioedema (OAA), a rare but potentially life-threatening side effect. We report the case of a 32-year-old woman who over 24 h experienced OAA after thrombolysis for an acute ischaemic left hemispheric stroke. We discuss the pathophysiology of this rare phenomenon.

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