Rare disease: Hypophosphataemia-inducing mesenchymal tumour in the foot

doi:10.1136/bcr.06.2009.2034

BMJ Case Rep. 2010; 2010: bcr0620092034.

Published online 2010 October 6. doi: 10.1136/bcr.06.2009.2034

PMCID: PMC3027923

Rare disease

Hypophosphataemia-inducing mesenchymal tumour in the foot

Christa Bauer,¹ Rolf Brücker,² Stefan Bützberger,³ and Christoph Schmid⁴

¹Praxis, Muri, Switzerland

²Hirslanden-Klinik St Anna, Luzern, Switzerland

³Department of Rheumatology, aarReha Schinznach, Schinznach Bad, Switzerland

⁴Division of Endocrinology, University Hospital Zürich, Zürich, Switzerland

Correspondence to Christa Bauer, Email: christa.bauer/at/hin.ch

Abstract

Tumour-induced (or oncogenic) osteomalacia is a paraneoplastic syndrome characterised by progressive fatigue, muscle weakness, bone pain, non-healing and recurrent fractures caused by mesenchymal tumours that secrete proteins that inhibit renal phosphate transport and 1α-hydroxylation of 25-OH-vitamin D. The potentially curative treatment of choice is complete surgical excision of the tumour.

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