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BMJ Case Rep. 2010; 2010: bcr0920103324.
Published online 2010 December 2. doi:  10.1136/bcr.09.2010.3324
PMCID: PMC3027814
Rare disease

POEMS syndrome – a unique presentation of a rare paraneoplastic syndrome


POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder. A 40-year-old male with a history of peripheral neuropathy and erectile dysfunction presented with a pathological fracture of the neck of the femur, found to be a solitary plasmacytoma. Additional unusual features included splenomegaly, hyperprolactinaemia and skin changes. The patient had a total hip replacement at a specialist orthopaedic hospital and is due to undergo radiotherapy to the femoral lesion and autologous stem cell transplantation.

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