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Logo of bmjcrInstructions for authorsCurrent ToCBMJ Case Reports
BMJ Case Rep. 2010; 2010: bcr0120102630.
Published online Nov 23, 2010. doi:  10.1136/bcr.01.2010.2630
PMCID: PMC3027635
Unusual association of diseases/symptoms
A series report of autoimmune hypothyroidism associated with Hashimoto's encephalopathy: an under diagnosed clinical entity with good prognosis
Hemanta Kumar Nayak,1 Mrudul Kumar Daga,1 Rakshit Kumar,2 Sandeep Kumar Garg,2 Naresh Kumar,2 and Pankaj Kumar Mohanty3
1Department of Medicine, Maulana Azad Medical College, New Delhi, India
2Maulana Azad Medical College, New Delhi, India
3Department of Paediatrics, Maulana Azad Medical College, New Delhi, India
Correspondence to Hemanta Kumar Nayak, drhemantnayak/at/
Thyroid dysfunctions may be accompanied by numerous neurological and psychiatric disorders. The most well-known is cognitive impairment and depression in hypothyroid patients, as well as an increased risk of cerebrovascular accidents. A separate, although a rare entity, is Hashimoto's encephalopathy. Unlike encephalopathy associated with other conditions, management in Hashimoto's encephalopathy highly responds to steroid treatment and may be associated with normal thyroid profile at presentation. Hashimoto's encephalopathy, while rare, may have been under-recognised since its clinical presentation overlaps several more common disorders, such as depression, seizures or anxiety. We present two cases of hypothyroidism with peculiar presentation. The first case has rapidly progressive neurological dysfunction, normal thyroid function at presentation, normal MRI finding and responds to steroid treatment. The second case has a subacute progressive neurological deterioration with elevated thyroid-stimulating hormone titre at presentation. Both these cases are known hypothyroidism on regular thyroxin replacement therapy with elevated anti-thyroid peroxidase antibodies. We conclude that Hashimoto's encephalopathy can present with a wide spectrum of neurological illnesses in the setting of hypothyroidism. Thyroid status may vary from hypothyroid, normothyroid to even hyperthyroid. This condition usually has an abnormal electroencephalography (EEG) background and usually responds to high dose steroids.
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