To identify relevant articles published between March 1, 2009 and February 28, 2010, we reviewed the contents of leading medical journals including: the New England Journal of Medicine, the Journal of the American Medical Association, Annals of Internal Medicine, Archives of Internal Medicine, British Medical Journal, Lancet, Obstetrics and Gynecology, American Journal of Obstetrics and Gynecology, Journal of General Internal Medicine, PLOS
Medicine, American Journal of Public Health, Circulation, Diabetes, and Diabetes Care. We also reviewed updates to the Cochrane database of systematic reviews, Guideline Clearinghouse, and the articles highlighted by the ACP Journal Club, Journal Watch and Journal Watch Women’s Health. Finally, we performed a MEDLINE search using the medical subject heading, “sex factors.” Those abstracts rated in the top third of importance by any author were read closely and rated by all authors. A process of individual ratings and multiple discussions was then used to reach consensus about the most important articles published in the last year.