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Logo of bmcgenoBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Genomics
 
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Published online 2010 December 2. doi: 10.1186/1471-2164-11-690

Figure 9

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Diagram of proposed mRNA translation control pathways. Translating mRNAs are normally associated with eIF4F, which ultimately leads to the initiation of protein synthesis. In a process that can be mediated by stress sensors in the yeast cell plasma membrane, non-translating mRNAs may become associated with P-bodies that may lead to either mRNA decay or temporary sequestration of mRNAs for subsequent retrieval to the translating mRNA pool after adaptation to the stress. A novel eIF2α-P-containing complex is proposed as an alternative pathway for sequestration of non-translating RP mRNAs (blue-lined box). Asterisks identify immunoprecipitated proteins that were associated to translating or non-translating mRNAs in this study.

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