PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jcinvestThe Journal of Clinical InvestigationCurrent IssueArchiveSubscriptionAbout the Journal
 
J Clin Invest. 1974 July; 54(1): 98–103.
PMCID: PMC301528

Dermatitis Herpetiformis IMMUNOLOGIC CONCOMITANTS OF SMALL INTESTINAL DISEASE AND RELATIONSHIP TO HISTOCOMPATIBILITY ANTIGEN HL-A8

Abstract

In the present study the relation between the gluten-sensitive intestinal lesion observed in dermatitis herpetiformis (DH) and in gluten-sensitive enteropathy (coeliac sprue) (GSE) was analyzed. Jejunal IgA synthesis in DH was estimated from the extent of incorporation of [14C]leucine into IgA in jejunal biopsy specimens during short-term in vitro culture. Patients with DH have significantly elevated incorporation values as compared to normal control individuals (18,880±13,614 vs. 5,830±3,190 cpm/mg tissue protein/ 90 min) (P < 0.02) and the degree of elevation correlates well with the degree of morphologic abnormality. Thus patients with DH are similar to patients with GSE where elevated local mucosal IgA synthesis has also been observed.

By using both morphologic and immunologic criteria for evaluating intestinal status, patients with DH and intestinal disease were distinguished from patients with DH free of intestinal disease. Of the eight patients in the former group, seven carried HL-A8 (87.5%), an incidence which is strikingly similar to that observed in patients with GSE alone (88.5%). In contrast, of the seven patients in the latter group (without gastro-intestinal disease) two had HL-A8, an incidence (27%) not significantly different from that in the normal population (20%) (P > 0.1).

Thus, both in respect to local mucosal increase in IgA synthetic rates and in respect to the association with HL-A8, the intestinal lesion of DH is similar to that of GSE.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (999K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Marks J, Shuster S, Watson AJ. Small-bowel changes in dermatitis herpetiformis. Lancet. 1966 Dec 10;2(7476):1280–1282. [PubMed]
  • Fry L, Keir P, McMinn RM, Cowan JD, Hoffbrand AV. Small-intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet. 1967 Oct 7;2(7519):729–733. [PubMed]
  • Fraser NG, Murray D, Alexander JO. Structure and function of the small intestine in dermatitis herpetiformis. Br J Dermatol. 1967 Oct;79(10):509–518. [PubMed]
  • Brow JR, Parker F, Weinstein WM, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. I. Severity and distribution of the small intestinal lesion and associated malabsorption. Gastroenterology. 1971 Mar;60(3):355–361. [PubMed]
  • Weinstein WM, Brow JR, Parker F, Rubin CE. The small intestinal mucosa in dermatitis herpetiformis. II. Relationship of the small intestinal lesion to gluten. Gastroenterology. 1971 Mar;60(3):362–369. [PubMed]
  • Falchuk ZM, Rogentine GN, Strober W. Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest. 1972 Jun;51(6):1602–1605. [PMC free article] [PubMed]
  • Katz SI, Falchuk ZM, Dahl MV, Rogentine GN, Strober W. HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy. J Clin Invest. 1972 Nov;51(11):2977–2980. [PMC free article] [PubMed]
  • Falchuk ZM, Strober W. Increased jejunal immunoglobulin synthesis in patients with nontropical sprue as measured by a solid phase immunoadsorption technique. J Lab Clin Med. 1972 Jun;79(6):1004–1013. [PubMed]
  • BRANDBORG LL, RUBIN GE, QUINTON WE. A multipurpose instrument for suction biopsy of the esophagus, stomach, small bowel, and colon. Gastroenterology. 1959 Jul;37(1):1–16. [PubMed]
  • Falchuk ZM, Gebhard RL, Sessoms C, Strober W. An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture. J Clin Invest. 1974 Feb;53(2):487–500. [PMC free article] [PubMed]
  • Dahlqvist A. Assay of intestinal disaccharidases. Anal Biochem. 1968 Jan;22(1):99–107. [PubMed]
  • LOWRY OH, ROSEBROUGH NJ, FARR AL, RANDALL RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed]
  • WATERS AH, MOLLIN DL. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. [PMC free article] [PubMed]
  • Mittal KK, Mickey MR, Singal DP, Terasaki PI. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. [PubMed]
  • Stokes PL, Asquith P, Holmes GK, Mackintosh P, Cooke WT. Histocompatibility antigens associated with adult coeliac disease. Lancet. 1972 Jul 22;2(7769):162–164. [PubMed]
  • Hobbs JR, Hepner GW, Douglas AP, Crabbé PA, Johansson SG. Immunological mystery of coeliac disease. Lancet. 1969 Sep 20;2(7621):649–650. [PubMed]
  • Fraser NG, Dick HM, Crichton WB. Immunoglobulins in dermatitis herpetiformis and various other skin diseases. Br J Dermatol. 1969 Feb;81(2):89–95. [PubMed]
  • McClelland DB, Parkin DM, Heading RC, Barnetson RS, Warwick RR, Shearman DJ. Small-intestinal immunoglobulin levels in dermatitis herpetiformis. Lancet. 1972 Nov 25;2(7787):1108–1110. [PubMed]
  • Gebhard RL, Katz SI, Marks J, Shuster S, Trapani RJ. HL-A antigen type and small-intestinal disease in dermatitis herpetiformis. Lancet. 1973 Oct 6;2(7832):760–762. [PubMed]
  • McDevitt HO, Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. [PubMed]
  • RUBIN W, FAUCI AS, MARVIN SF, SLEISENGER MH, JEFRIES GH. IMMUNOFLUORESCENT STUDIES IN ADULT CELIAC DISEASE. J Clin Invest. 1965 Mar;44:475–485. [PMC free article] [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation