PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of dmmeTOCContact usSubmitCurrent IssueView PDFAbout UsDMM
 
Dis Model Mech. 2011 January; 4(1): 1.
PMCID: PMC3014330

Shock therapy: modulating stem cells

Understanding mechanisms of stem cell regulation is crucial for regenerative medicine as well as for new therapies for developmental defects and cancer. Using Xenopus laevis neural crest, an embryonic stem cell population, as a model system, Blackiston et al. show that modulating the bioelectrical state of a population of ‘instructor’ cells expressing the native glycine receptor chloride channel can trigger a neoplastic phenotype in other cells, an effect that is mediated by long-range serotonergic signalling. Modulating membrane voltage is therefore a potentially powerful therapeutic approach for manipulating stem cells.

Page 67


Articles from Disease Models & Mechanisms are provided here courtesy of Company of Biologists