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Published online 2010 December 31. doi: 10.1371/journal.pone.0015938

Figure 2

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tp53 and its targets were upregulated in all studied mutants.

A) The level of tp53 upregulation varied between mutants. B) Δ113tp53 is a p53 target and p53 inhibitor, a part of p53 autoregulatory loop. C–D) Cell cycle suppressor cdkn1a (p21) and cyclin G1 were upregulated. E–F) Pro-apoptotic puma and bax were upregulated in mutants. 48 hpf, qPCR.

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