In the crystal structure of the title compound, C15H16N2O5S, the azomethine adopts the E configuration. The two heterocyclic rings adopt an antiperiplanar orientation. The mean planes of the thiophene and furan rings are twisted by 2.51 (4)°. The crystal structure exhibits intermolecular N—HO hydrogen bonding. π–π stacking is also observed, the centroid-to-centroid distance being 3.770 (4) Å.