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Acta Crystallogr Sect E Struct Rep Online. 2010 September 1; 66(Pt 9): o2351.
Published online 2010 August 18. doi:  10.1107/S1600536810031600
PMCID: PMC3008072

5-(2-Hy­droxy­phen­yl)-3-methyl-4,5-di­hydro-1H-pyrazole-1-carbaldehyde

Abstract

In the title compound, C11H12N2O2, the dihydro­pyrazole and benzene rings are oriented at a dihedral angle of 68.35 (5)°. The dihydro­pyrazole ring is planar, with a mean deviation from the mean plane of 0.0409 Å. The crystal structure is stabilized by O—H(...)O and C—H(...)O hydrogen bonds.

Related literature

For the anti­bacterial bioactivity of pyrazole derivatives, see: Bekhita & Abdel-Aziem (2004 [triangle]); Tanitame et al. (2004a [triangle],b [triangle]). For the biological properties of dihydro­pyrazole derivatives, see: Dmytro et al. (2009 [triangle]); Need et al. (2006 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-66-o2351-scheme1.jpg

Experimental

Crystal data

  • C11H12N2O2
  • M r = 204.23
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-66-o2351-efi1.jpg
  • a = 7.3835 (15) Å
  • b = 13.454 (3) Å
  • c = 10.507 (2) Å
  • β = 106.46 (3)°
  • V = 1001.0 (3) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.10 mm−1
  • T = 293 K
  • 0.21 × 0.16 × 0.11 mm

Data collection

  • Bruker SMART APEX CCD area-detector diffractometer
  • Absorption correction: multi-scan (SADABS; Bruker, 2001 [triangle]) T min = 0.980, T max = 0.990
  • 5606 measured reflections
  • 1957 independent reflections
  • 1579 reflections with I > 2σ(I)
  • R int = 0.019

Refinement

  • R[F 2 > 2σ(F 2)] = 0.033
  • wR(F 2) = 0.086
  • S = 1.08
  • 1957 reflections
  • 138 parameters
  • H-atom parameters constrained
  • Δρmax = 0.20 e Å−3
  • Δρmin = −0.18 e Å−3

Data collection: SMART (Bruker, 2001 [triangle]); cell refinement: SAINT (Bruker, 2001 [triangle]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: SHELXTL (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXL97.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536810031600/ez2216sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810031600/ez2216Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Comment

There has been much research interest in pyrazole derivatives due to their antibacterial bioactivities (Bekhita et al., 2004; Tanitame et al., 2004a; Tanitame et al., 2004b). Dihydropyrazole-based derivatives have shown several biological activities as CB1 antagonists and tumor necrosis inhibitors (Dmytro et al., 2009; Need et al., 2006). In this paper, we report the synthesis and crystal structure of 5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazole-1-carbaldehyde (I).

The title compound crystallizes in the centrosymmetric space group P21/n. As shown in Fig. 1, the C—N single and double bond lengths are both in the normal ranges [C5—N1 single bond is 1.4826 (15) Å, C12═N2 double bond is 1.2797 (17) Å]. The bond lengths of C3—C12 and C3—C5 are 1.5002 (17) and 1.5421 (18) Å, respectively, which indicate that they are both single bonds. The dihedral angle between the dihydropyrazole and benzene rings is 68.35 (5) °. The dihydropyrazole ring adopts a planar conformation, with a mean deviation from the mean plane of 0.0409 Å. The intermolecular O2—H2···O1 and C4—H4B···O1 hydrogen bonds connect the molecules to form a three-dimensional network (Fig. 2).

Experimental

To a solution of 4-(2-hydroxyphenyl)but-3-en-2-one (0.81 g, 5 mmol) in formic acid (10 ml) was added hydrazine monohydrate (1.25 ml, 25 mmol) and the reaction mixture was refluxed for 2 h. The solvent was evaporated and cold water (30 ml) was added to the oily residue. The resultant precipitate was filtered, recrystallized from ethanol, and colorless single crystals were obtained after 1 day. Mp 155–156 °C. Analysis found: C, 64.5; H, 6.1; N, 14.0%; calculated for C11H12N2O2: C, 64.7; H, 5.9; N, 13.7%. 1H NMR (300 MHz, CDCl3, δ, p.p.m.): 2.19 (s, 3H, –Me), 3.10 (dd, J = 18.7 and 3.7 Hz, 1H, pyrazole), 3.39 (dd, J = 11.2 and 18.6 Hz, 1H, pyrazole), 5.67 (dd, J = 11.6 and 3.5 Hz, 1H, pyrazole), 6.89–7.26 (m, 5H, ArH and –OH), 8.63 (s, 1H, –COH).

Refinement

All the H atoms were placed in idealized positions (C—H = 0.93–0.97, O—H = 0.82 Å) and refined as riding with Uiso(H) = 1.2Ueq(C) or 1.5Ueq(C) for methyl H atoms and Uiso(H) = 1.5Ueq(O).

Figures

Fig. 1.
The crystal structure of (I), showing the atom numbering scheme and 35% probability displacement ellipsoids (arbitrary spheres for the H atoms).
Fig. 2.
The crystal packing of (I), viewed along the a axis. Hydrogen bonds are shown as dashed lines.

Crystal data

C11H12N2O2F(000) = 432
Mr = 204.23Dx = 1.355 Mg m3
Monoclinic, P21/nMo Kα radiation, λ = 0.71073 Å
a = 7.3835 (15) ÅCell parameters from 972 reflections
b = 13.454 (3) Åθ = 3.5–24.7°
c = 10.507 (2) ŵ = 0.10 mm1
β = 106.46 (3)°T = 293 K
V = 1001.0 (3) Å3Block, colorless
Z = 40.21 × 0.16 × 0.11 mm

Data collection

Bruker Smart APEX CCD area-detector diffractometer1957 independent reflections
Radiation source: fine-focus sealed tube1579 reflections with I > 2σ(I)
graphiteRint = 0.019
phi and ω scansθmax = 26.0°, θmin = 3.0°
Absorption correction: multi-scan (SADABS; Bruker, 2001)h = −9→8
Tmin = 0.980, Tmax = 0.990k = −16→13
5606 measured reflectionsl = −12→12

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.033Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.086H-atom parameters constrained
S = 1.08w = 1/[σ2(Fo2) + (0.0484P)2 + 0.0583P] where P = (Fo2 + 2Fc2)/3
1957 reflections(Δ/σ)max < 0.001
138 parametersΔρmax = 0.20 e Å3
0 restraintsΔρmin = −0.18 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
C10.71057 (17)0.62387 (9)0.66395 (12)0.0271 (3)
H10.63780.65930.59140.032*
C20.81434 (16)0.41527 (9)0.51386 (12)0.0253 (3)
C30.7931 (2)0.35621 (10)0.39114 (13)0.0350 (3)
H3A0.72640.29580.39630.052*
H3B0.91570.34060.38200.052*
H3C0.72350.39410.31570.052*
C40.93391 (17)0.38472 (9)0.64868 (12)0.0260 (3)
H4A1.06700.38590.65340.031*
H4B0.90040.31870.67150.031*
C50.88677 (16)0.46406 (8)0.74008 (11)0.0225 (3)
H51.00310.49630.79250.027*
C60.77821 (16)0.42376 (8)0.83124 (11)0.0215 (3)
C70.58407 (17)0.42893 (9)0.80332 (12)0.0284 (3)
H70.51370.45640.72340.034*
C80.49282 (18)0.39382 (10)0.89242 (14)0.0341 (3)
H80.36210.39850.87300.041*
C90.59650 (18)0.35179 (10)1.01025 (13)0.0320 (3)
H90.53570.32941.07120.038*
C100.78979 (18)0.34274 (9)1.03825 (12)0.0276 (3)
H100.85870.31261.11670.033*
C110.88131 (16)0.37877 (8)0.94901 (11)0.0221 (3)
N10.77351 (14)0.53492 (7)0.64102 (9)0.0237 (2)
N20.72976 (14)0.49870 (8)0.51056 (9)0.0259 (3)
O10.74131 (13)0.66270 (6)0.77367 (9)0.0335 (2)
O21.07147 (12)0.37142 (7)0.97002 (8)0.0306 (2)
H21.12270.36251.04930.046*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
C10.0288 (6)0.0248 (7)0.0264 (7)0.0022 (5)0.0059 (5)0.0068 (5)
C20.0238 (6)0.0293 (7)0.0251 (6)−0.0015 (5)0.0107 (5)0.0023 (5)
C30.0377 (7)0.0404 (8)0.0272 (7)0.0047 (6)0.0099 (6)−0.0024 (6)
C40.0282 (6)0.0268 (7)0.0248 (6)0.0030 (5)0.0104 (5)0.0037 (5)
C50.0231 (6)0.0216 (6)0.0219 (6)0.0008 (5)0.0049 (5)0.0044 (5)
C60.0266 (6)0.0175 (6)0.0208 (6)−0.0009 (5)0.0073 (5)−0.0007 (4)
C70.0262 (6)0.0293 (7)0.0282 (7)−0.0012 (5)0.0051 (5)0.0045 (5)
C80.0249 (6)0.0382 (8)0.0407 (8)−0.0045 (5)0.0117 (6)0.0015 (6)
C90.0383 (7)0.0324 (7)0.0306 (7)−0.0097 (6)0.0183 (6)−0.0016 (5)
C100.0383 (7)0.0248 (7)0.0203 (6)−0.0020 (5)0.0092 (5)0.0012 (5)
C110.0264 (6)0.0184 (6)0.0218 (6)0.0009 (5)0.0074 (5)−0.0028 (5)
N10.0286 (5)0.0233 (5)0.0188 (5)0.0018 (4)0.0059 (4)0.0037 (4)
N20.0275 (5)0.0306 (6)0.0200 (5)0.0001 (4)0.0072 (4)0.0026 (4)
O10.0418 (5)0.0275 (5)0.0279 (5)0.0067 (4)0.0047 (4)−0.0002 (4)
O20.0267 (5)0.0416 (6)0.0228 (4)0.0073 (4)0.0059 (3)0.0066 (4)

Geometric parameters (Å, °)

C1—O11.2269 (15)C5—H50.9800
C1—N11.3303 (16)C6—C71.3811 (17)
C1—H10.9300C6—C111.3940 (16)
C2—N21.2802 (16)C7—C81.3824 (19)
C2—C31.4846 (18)C7—H70.9300
C2—C41.4988 (17)C8—C91.3790 (19)
C3—H3A0.9600C8—H80.9300
C3—H3B0.9600C9—C101.3785 (18)
C3—H3C0.9600C9—H90.9300
C4—C51.5403 (17)C10—C111.3892 (18)
C4—H4A0.9700C10—H100.9300
C4—H4B0.9700C11—O21.3617 (15)
C5—N11.4828 (14)N1—N21.4034 (14)
C5—C61.5129 (17)O2—H20.8200
O1—C1—N1124.90 (11)C7—C6—C11118.90 (12)
O1—C1—H1117.5C7—C6—C5123.48 (11)
N1—C1—H1117.5C11—C6—C5117.62 (11)
N2—C2—C3121.01 (11)C6—C7—C8120.97 (12)
N2—C2—C4114.73 (11)C6—C7—H7119.5
C3—C2—C4124.26 (11)C8—C7—H7119.5
C2—C3—H3A109.5C9—C8—C7119.67 (12)
C2—C3—H3B109.5C9—C8—H8120.2
H3A—C3—H3B109.5C7—C8—H8120.2
C2—C3—H3C109.5C10—C9—C8120.38 (13)
H3A—C3—H3C109.5C10—C9—H9119.8
H3B—C3—H3C109.5C8—C9—H9119.8
C2—C4—C5102.86 (9)C9—C10—C11119.81 (12)
C2—C4—H4A111.2C9—C10—H10120.1
C5—C4—H4A111.2C11—C10—H10120.1
C2—C4—H4B111.2O2—C11—C10122.79 (11)
C5—C4—H4B111.2O2—C11—C6117.01 (11)
H4A—C4—H4B109.1C10—C11—C6120.20 (11)
N1—C5—C6112.35 (10)C1—N1—N2119.59 (9)
N1—C5—C4100.95 (9)C1—N1—C5127.43 (10)
C6—C5—C4113.59 (10)N2—N1—C5112.98 (9)
N1—C5—H5109.9C2—N2—N1107.61 (9)
C6—C5—H5109.9C11—O2—H2109.5
C4—C5—H5109.9
N2—C2—C4—C57.20 (14)C7—C6—C11—O2177.26 (11)
C3—C2—C4—C5−173.35 (11)C5—C6—C11—O2−2.42 (15)
C2—C4—C5—N1−8.69 (12)C7—C6—C11—C10−2.02 (17)
C2—C4—C5—C6111.79 (11)C5—C6—C11—C10178.30 (10)
N1—C5—C6—C717.36 (16)O1—C1—N1—N2−179.59 (11)
C4—C5—C6—C7−96.46 (14)O1—C1—N1—C51.7 (2)
N1—C5—C6—C11−162.98 (10)C6—C5—N1—C166.03 (15)
C4—C5—C6—C1183.21 (13)C4—C5—N1—C1−172.61 (11)
C11—C6—C7—C82.53 (19)C6—C5—N1—N2−112.71 (11)
C5—C6—C7—C8−177.80 (12)C4—C5—N1—N28.64 (12)
C6—C7—C8—C9−0.9 (2)C3—C2—N2—N1178.62 (11)
C7—C8—C9—C10−1.4 (2)C4—C2—N2—N1−1.92 (14)
C8—C9—C10—C111.87 (19)C1—N1—N2—C2176.47 (11)
C9—C10—C11—O2−179.39 (11)C5—N1—N2—C2−4.68 (13)
C9—C10—C11—C6−0.16 (18)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
O2—H2···O1i0.821.882.6954 (14)175.
C4—H4B···O1ii0.972.483.4438 (16)170.

Symmetry codes: (i) −x+2, −y+1, −z+2; (ii) −x+3/2, y−1/2, −z+3/2.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: EZ2216).

References

  • Bekhita, A. A. & Abdel-Aziem, T. (2004). Bioorg. Med. Chem.12, 1935–1945. [PubMed]
  • Bruker (2001). SAINT, SMART and SADABS Bruker AXS Inc., Madison, Wisconsin, USA.
  • Dmytro, H., Borys, Z., Olexandr, V., Lucjusz, Z., Andrzej, G. & Roman, L. (2009). Eur. J. Med. Chem.44, 1396–1404. [PubMed]
  • Need, A. B., Davis, R. J., Alexander-Chacko, J. T., Eastwood, B., Chernet, E., Phebus, L. A., Sindelar, D. K. & Nomikos, G. G. (2006). Psychopharmacology (Berlin), 184, 26–35. [PubMed]
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Tanitame, A., Oyamada, Y., Ofuji, K., Fujimoto, M., Suzuki, K., Ueda, T., Terauchi, H., Kawasaki, M., Nagai, K., Wachie, M. & Yamagishib, J. I. (2004b). Bioorg. Med. Chem.12, 5515–5524. [PubMed]
  • Tanitame, A., Oyamada, Y., Ofuji, K., Kyoya, Y., Suzuki, K., Ito, H., Kawasaki, M., Nagai, K., Wachid, M. & Yamagishi, J. I. (2004a). Bioorg. Med. Chem. Lett.14, 2857–2862. [PubMed]

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