PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of actaeInternational Union of Crystallographysearchopen accessarticle submissionjournal home pagethis article
 
Acta Crystallogr Sect E Struct Rep Online. 2010 August 1; 66(Pt 8): o2072.
Published online 2010 July 21. doi:  10.1107/S1600536810027467
PMCID: PMC3007513

Ethyl 2-{[7-fluoro-4-oxo-3-(1H-1,2,4-triazol-1-yl)-4H-thio­chromen-2-yl]sulfan­yl}acetate

Abstract

In the title compound, C15H12FN3O3S2, the two six-membered rings are essentially coplanar, their mean plnes making a dihedral angle of 1.1 (2)°. The carbonyl C, the two attached non-fused C atoms and the S atom deviate from the plane of the benzene ring by −0.046 (5), −0.017 (5), 0.000 (6), 0.026 (4) Å, respectively. The angle between the mean planes of the triazole ring and the sulfur heterocycle is 53.3 (1)°. In the crystal, inter­molecular C—H(...)O hydrogen bonds link the mol­ecules in a stacked arrangement along the a axis.

Related literature

For related compounds containing a 4H-thio­chromen-4-one fragment, see: Adams et al. (1991 [triangle]); Nakazumi et al. (1992 [triangle]); Weiss et al. (2008 [triangle]); Li et al. (2010 [triangle]). For bond-length data, see: Allen et al. (1987 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-66-o2072-scheme1.jpg

Experimental

Crystal data

  • C15H12FN3O3S2
  • M r = 365.40
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-66-o2072-efi1.jpg
  • a = 9.3890 (19) Å
  • b = 8.2430 (16) Å
  • c = 20.861 (4) Å
  • β = 100.72 (3)°
  • V = 1586.3 (5) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.37 mm−1
  • T = 293 K
  • 0.30 × 0.20 × 0.10 mm

Data collection

  • Enraf–Nonius CAD-4 diffractometer
  • Absorption correction: ψ scan (North et al., 1968 [triangle]) T min = 0.898, T max = 0.964
  • 3053 measured reflections
  • 2867 independent reflections
  • 2186 reflections with I > 2σ(I)
  • R int = 0.013
  • 3 standard reflections every 200 reflections intensity decay: 1%

Refinement

  • R[F 2 > 2σ(F 2)] = 0.044
  • wR(F 2) = 0.151
  • S = 1.00
  • 2867 reflections
  • 217 parameters
  • H-atom parameters constrained
  • Δρmax = 0.22 e Å−3
  • Δρmin = −0.32 e Å−3

Data collection: CAD-4 EXPRESS (Enraf–Nonius, 1985 [triangle]); cell refinement: CAD-4 EXPRESS; data reduction: XCAD4 (Harms & Wocadlo, 1995 [triangle]); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: PLATON (Spek, 2009 [triangle]); software used to prepare material for publication: SHELXTL (Sheldrick, 2008 [triangle]).

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810027467/zq2047sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810027467/zq2047Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

The authors thank the Center of Testing and Analysis, Nanjing University, for support.

supplementary crystallographic information

Comment

The title compound, ethyl 2-((7-fluoro-4-oxo-3-(1H-1,2,4-triazol-1-yl)-4H-thiochromen-2-yl)thio) acetate (I), is a new molecule which has a potential use as antifungal. We herein report its crystal structure.

The molecular structure of (I) is shown in Fig. 1, and selected geometric parameters are given in Table 1. The bond lengths and angles (Table 1) are within normal ranges (Allen et al., 1987). The two-ring system is essentially planar [angle between the mean planes = 1.1 (2)°]. The atoms C7, C8, C15 and S2 deviate from the benzene ring by -0.046 (5), -0.017 (5), 0.000 (6), 0.026 (4) Å, respectively. The angle between the mean planes of the triazole ring and the sulfur heterocycle is 53.3 (1)°.

In the crystal packing, a weak intramolecular C4—H4B···S2 interaction is observed, and intermolecular C—H···O hydrogen bonds link the molecules in a stacked arrangement along the a axis.

Experimental

CS2 (2.0 g, 26.3 mmol) was dropwise added to a solution of 1-(2,4- difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (5 g, 22.4 mmol) in DMSO (20 ml) containing NaOH (1.8 g, 45 mmol). The yellow solution was stirred for about 2 h at room temperature. Then ethyl bromoacetate (3.8 g, 22.4 mmol) was dropwise added to the intermediate. After 3 h, the solution was poured into water (50 ml). The crystalline product was isolated by filtration, and washed with water (300 ml). The crystals were obtained by dissolving (I) in acetone (20 ml) and evaporating acetone slowly at room temperature for about 7 d.

Refinement

H atoms were positioned geometrically with C—H = 0.93 Å for aromatic H atoms, C—H = 0.97 Å for methylene H atoms,and with C—H = 0.96 Å for methyl H atoms, and constrained to ride on their parent atoms with Uiso(H) = xUeq(C), where x = 1.2 for aromatic and methylene H atoms and x = 1.5 for methyl H atoms.

Figures

Fig. 1.
The molecular structure of (I), with the atom-numbering scheme. Displacement ellipsoids are drawn at the 50% probability level.
Fig. 2.
A packing diagram of (I). Intra- and inter-molecular interactions are shown as dashed lines.

Crystal data

C15H12FN3O3S2F(000) = 752
Mr = 365.40Dx = 1.530 Mg m3
Monoclinic, P21/cMelting point: 397 K
Hall symbol: -P 2ybcMo Kα radiation, λ = 0.71073 Å
a = 9.3890 (19) ÅCell parameters from 25 reflections
b = 8.2430 (16) Åθ = 9–14°
c = 20.861 (4) ŵ = 0.37 mm1
β = 100.72 (3)°T = 293 K
V = 1586.3 (5) Å3Block, pink
Z = 40.30 × 0.20 × 0.10 mm

Data collection

Enraf–Nonius CAD-4 diffractometer2186 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.013
graphiteθmax = 25.3°, θmin = 2.0°
ω/2θ scansh = 0→11
Absorption correction: ψ scan (North et al., 1968)k = 0→9
Tmin = 0.898, Tmax = 0.964l = −25→24
3053 measured reflections3 standard reflections every 200 reflections
2867 independent reflections intensity decay: 1%

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.044Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.151H-atom parameters constrained
S = 1.00w = 1/[σ2(Fo2) + (0.1P)2 + 0.170P] where P = (Fo2 + 2Fc2)/3
2867 reflections(Δ/σ)max < 0.001
217 parametersΔρmax = 0.22 e Å3
0 restraintsΔρmin = −0.32 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
F0.2497 (3)0.9099 (3)−0.12075 (10)0.0728 (7)
S1−0.10898 (8)0.52611 (10)0.15706 (4)0.0434 (3)
O10.3016 (2)0.6102 (3)0.23375 (11)0.0473 (6)
N1−0.5765 (3)0.6974 (5)0.09253 (17)0.0721 (10)
C10.5439 (4)0.6893 (6)0.2766 (2)0.0871 (15)
H1B0.60650.77810.29280.131*
H1C0.57380.64380.23880.131*
H1D0.54940.60770.30980.131*
S20.06614 (8)0.65095 (9)0.06388 (3)0.0375 (2)
O20.1081 (3)0.7704 (3)0.22875 (11)0.0554 (6)
N2−0.4048 (3)0.5142 (4)0.07917 (15)0.0562 (8)
C20.3947 (4)0.7475 (5)0.2588 (2)0.0614 (10)
H2B0.38840.83120.22570.074*
H2C0.36350.79350.29670.074*
N3−0.3597 (3)0.6709 (3)0.07017 (13)0.0472 (7)
O3−0.3528 (3)0.8531 (3)−0.03655 (13)0.0646 (7)
C30.1619 (3)0.6420 (4)0.21998 (13)0.0372 (7)
C40.0790 (3)0.4931 (3)0.19245 (14)0.0382 (7)
H4A0.08400.41360.22710.046*
H4B0.12690.44680.15930.046*
C5−0.5331 (4)0.5401 (6)0.0927 (2)0.0673 (11)
H5A−0.59170.45560.10200.081*
C6−0.4652 (4)0.7752 (5)0.07764 (19)0.0601 (10)
H6A−0.46010.88710.07290.072*
C7−0.2261 (3)0.6990 (4)0.04953 (14)0.0378 (7)
C8−0.2363 (3)0.7960 (4)−0.00981 (15)0.0428 (7)
C9−0.1040 (3)0.8222 (3)−0.03656 (14)0.0386 (7)
C10−0.1155 (4)0.9141 (4)−0.09443 (15)0.0473 (8)
H10A−0.20520.9558−0.11380.057*
C110.0020 (4)0.9427 (4)−0.12239 (16)0.0521 (9)
H11A−0.00681.0032−0.16060.063*
C120.1336 (4)0.8808 (4)−0.09318 (16)0.0490 (8)
C130.1538 (4)0.7913 (4)−0.03709 (15)0.0432 (7)
H13A0.24450.7502−0.01880.052*
C140.0329 (3)0.7637 (3)−0.00815 (13)0.0357 (7)
C15−0.1023 (3)0.6355 (3)0.08501 (14)0.0362 (7)

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
F0.0870 (16)0.0758 (15)0.0678 (14)−0.0063 (13)0.0462 (12)0.0109 (12)
S10.0411 (4)0.0490 (5)0.0400 (4)−0.0036 (4)0.0071 (3)0.0107 (3)
O10.0433 (12)0.0353 (12)0.0611 (14)−0.0009 (10)0.0037 (10)−0.0065 (10)
N10.0419 (17)0.088 (3)0.088 (2)−0.0022 (17)0.0173 (16)0.019 (2)
C10.052 (2)0.074 (3)0.128 (4)−0.007 (2)−0.003 (2)−0.028 (3)
S20.0376 (4)0.0383 (4)0.0366 (4)0.0003 (3)0.0071 (3)0.0057 (3)
O20.0633 (15)0.0396 (13)0.0589 (15)0.0130 (11)−0.0001 (11)−0.0129 (11)
N20.0419 (16)0.0521 (18)0.072 (2)−0.0130 (13)0.0024 (14)0.0184 (15)
C20.055 (2)0.045 (2)0.083 (3)−0.0150 (17)0.0077 (19)−0.0131 (18)
N30.0371 (14)0.0473 (16)0.0551 (16)−0.0067 (12)0.0029 (12)0.0093 (13)
O30.0485 (14)0.0726 (18)0.0679 (16)0.0057 (13)−0.0015 (12)0.0296 (14)
C30.0488 (18)0.0330 (16)0.0290 (14)0.0022 (14)0.0051 (12)0.0027 (12)
C40.0441 (16)0.0322 (16)0.0368 (15)0.0017 (13)0.0038 (13)0.0026 (13)
C50.044 (2)0.078 (3)0.076 (3)−0.017 (2)0.0012 (18)0.025 (2)
C60.0440 (19)0.058 (2)0.081 (3)0.0040 (18)0.0176 (18)0.013 (2)
C70.0348 (15)0.0327 (16)0.0456 (16)−0.0044 (13)0.0067 (12)0.0033 (13)
C80.0470 (18)0.0354 (16)0.0426 (16)−0.0047 (14)−0.0004 (14)0.0027 (14)
C90.0526 (18)0.0261 (15)0.0355 (15)−0.0016 (13)0.0038 (13)−0.0009 (12)
C100.063 (2)0.0363 (17)0.0384 (16)−0.0023 (16)−0.0007 (15)0.0038 (14)
C110.084 (3)0.0357 (18)0.0392 (17)−0.0022 (18)0.0171 (17)0.0065 (14)
C120.069 (2)0.0382 (18)0.0451 (18)−0.0060 (16)0.0244 (16)−0.0024 (15)
C130.0524 (18)0.0377 (17)0.0427 (16)−0.0012 (15)0.0168 (14)−0.0017 (14)
C140.0496 (18)0.0242 (14)0.0333 (15)−0.0043 (13)0.0074 (13)−0.0022 (12)
C150.0419 (16)0.0294 (15)0.0373 (15)−0.0054 (13)0.0077 (12)−0.0009 (12)

Geometric parameters (Å, °)

F—C121.345 (4)N3—C71.419 (4)
S1—C151.764 (3)O3—C81.226 (4)
S1—C41.802 (3)C3—C41.509 (4)
O1—C31.316 (4)C4—H4A0.9700
O1—C21.466 (4)C4—H4B0.9700
N1—C61.311 (4)C5—H5A0.9300
N1—C51.359 (5)C6—H6A0.9300
C1—C21.462 (5)C7—C151.361 (4)
C1—H1B0.9600C7—C81.461 (4)
C1—H1C0.9600C8—C91.469 (4)
C1—H1D0.9600C9—C141.397 (4)
S2—C151.723 (3)C9—C101.412 (4)
S2—C141.745 (3)C10—C111.361 (5)
O2—C31.201 (4)C10—H10A0.9300
N2—C51.305 (5)C11—C121.370 (5)
N2—N31.383 (4)C11—H11A0.9300
C2—H2B0.9700C12—C131.366 (5)
C2—H2C0.9700C13—C141.400 (4)
N3—C61.342 (4)C13—H13A0.9300
C15—S1—C4103.82 (14)N1—C5—H5A121.8
C3—O1—C2115.3 (3)N1—C6—N3110.6 (4)
C6—N1—C5102.4 (3)N1—C6—H6A124.7
C2—C1—H1B109.5N3—C6—H6A124.7
C2—C1—H1C109.5C15—C7—N3119.1 (3)
H1B—C1—H1C109.5C15—C7—C8125.8 (3)
C2—C1—H1D109.5N3—C7—C8115.1 (3)
H1B—C1—H1D109.5O3—C8—C7120.5 (3)
H1C—C1—H1D109.5O3—C8—C9121.1 (3)
C15—S2—C14103.51 (15)C7—C8—C9118.4 (3)
C5—N2—N3101.2 (3)C14—C9—C10117.7 (3)
C1—C2—O1108.4 (3)C14—C9—C8124.3 (3)
C1—C2—H2B110.0C10—C9—C8117.9 (3)
O1—C2—H2B110.0C11—C10—C9121.4 (3)
C1—C2—H2C110.0C11—C10—H10A119.3
O1—C2—H2C110.0C9—C10—H10A119.3
H2B—C2—H2C108.4C10—C11—C12118.7 (3)
C6—N3—N2109.3 (3)C10—C11—H11A120.7
C6—N3—C7130.1 (3)C12—C11—H11A120.7
N2—N3—C7120.3 (3)F—C12—C13117.9 (3)
O2—C3—O1124.9 (3)F—C12—C11118.6 (3)
O2—C3—C4125.0 (3)C13—C12—C11123.5 (3)
O1—C3—C4110.1 (2)C12—C13—C14117.6 (3)
C3—C4—S1115.4 (2)C12—C13—H13A121.2
C3—C4—H4A108.4C14—C13—H13A121.2
S1—C4—H4A108.4C9—C14—C13121.1 (3)
C3—C4—H4B108.4C9—C14—S2123.5 (2)
S1—C4—H4B108.4C13—C14—S2115.4 (2)
H4A—C4—H4B107.5C7—C15—S2124.3 (2)
N2—C5—N1116.4 (3)C7—C15—S1119.8 (2)
N2—C5—H5A121.8S2—C15—S1115.82 (17)
C3—O1—C2—C1175.4 (3)C7—C8—C9—C10179.1 (3)
C5—N2—N3—C6−1.3 (4)C14—C9—C10—C111.1 (4)
C5—N2—N3—C7−175.4 (3)C8—C9—C10—C11−179.6 (3)
C2—O1—C3—O2−2.9 (5)C9—C10—C11—C12−0.2 (5)
C2—O1—C3—C4177.9 (3)C10—C11—C12—F−179.7 (3)
O2—C3—C4—S111.9 (4)C10—C11—C12—C13−0.1 (5)
O1—C3—C4—S1−168.9 (2)F—C12—C13—C14179.0 (3)
C15—S1—C4—C370.5 (2)C11—C12—C13—C14−0.6 (5)
N3—N2—C5—N10.9 (5)C10—C9—C14—C13−1.8 (4)
C6—N1—C5—N2−0.1 (5)C8—C9—C14—C13178.9 (3)
C5—N1—C6—N3−0.8 (4)C10—C9—C14—S2179.0 (2)
N2—N3—C6—N11.4 (4)C8—C9—C14—S2−0.2 (4)
C7—N3—C6—N1174.8 (3)C12—C13—C14—C91.6 (4)
C6—N3—C7—C15131.6 (4)C12—C13—C14—S2−179.2 (2)
N2—N3—C7—C15−55.7 (4)C15—S2—C14—C90.6 (3)
C6—N3—C7—C8−48.6 (5)C15—S2—C14—C13−178.6 (2)
N2—N3—C7—C8124.1 (3)N3—C7—C15—S2176.7 (2)
C15—C7—C8—O3−177.0 (3)C8—C7—C15—S2−3.0 (5)
N3—C7—C8—O33.3 (4)N3—C7—C15—S1−2.2 (4)
C15—C7—C8—C93.4 (5)C8—C7—C15—S1178.1 (2)
N3—C7—C8—C9−176.4 (3)C14—S2—C15—C70.9 (3)
O3—C8—C9—C14178.7 (3)C14—S2—C15—S1179.85 (16)
C7—C8—C9—C14−1.6 (4)C4—S1—C15—C7−171.9 (2)
O3—C8—C9—C10−0.6 (5)C4—S1—C15—S29.1 (2)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
C4—H4A···O2i0.972.473.199 (4)131
C4—H4B···S20.972.592.963 (3)103
C11—H11A···O2ii0.932.433.276 (4)151

Symmetry codes: (i) −x, y−1/2, −z+1/2; (ii) −x, −y+2, −z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: ZQ2047).

References

  • Adams, H., Bailey, N. A., Giles, P. R. & Marson, C. M. (1991). Acta Cryst. C47, 1332–1334.
  • Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1–19.
  • Enraf–Nonius (1985). CAD-4 EXPRESS Enraf–Nonius, Delft, The Netherlands.
  • Harms, K. & Wocadlo, S. (1995). XCAD4 University of Marburg, Germany.
  • Li, Y., Xiao, T., Liu, D. & Yu, G. (2010). Acta Cryst. E66, o694. [PMC free article] [PubMed]
  • Nakazumi, H., Watanabe, S. & Kitao, T. (1992). J. Chem. Res.212, 1616–1641.
  • North, A. C. T., Phillips, D. C. & Mathews, F. S. (1968). Acta Cryst. A24, 351–359.
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Spek, A. L. (2009). Acta Cryst. D65, 148–155. [PMC free article] [PubMed]
  • Weiss, R., Bess, M., Huber, S. M. & Heinemann, F. W. (2008). J. Am. Chem. Soc.130, 4610–4617. [PubMed]

Articles from Acta Crystallographica Section E: Structure Reports Online are provided here courtesy of International Union of Crystallography