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Logo of jcinvestThe Journal of Clinical InvestigationAbout the Journal
 
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Hitting puberty without a Kiss1

Neurons in the ventral premammillary nucleus (PMV) that control the onset of puberty through leptin signaling. A series of studies have shown that Kiss1 neurons mediate leptin’s effect on pubertal development, but Donato and colleagues (Page 355) use multiple genetic mouse models to find that leptin signaling in Kiss1 neurons is not required for the onset of puberty. Rather, the PMV, a previously unrecognized hypothalamic nucleus, serves as a key link between leptin and pubertal development.

J Clin Invest. 2011 January 4; 121(1): Cover