PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of wjgLink to Publisher's site
 
World J Gastroenterol. 2010 December 21; 16(47): 5907.
Published online 2010 December 21. doi:  10.3748/wjg.v16.i47.5907
PMCID: PMC3007108

Reverse cholesterol transport revisited

Abstract

Reverse cholesterol transport was originally described as the high-density lipoprotein-mediated cholesterol flux from the periphery via the hepatobiliary tract to the intestinal lumen, leading to fecal excretion. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated. In this topic highlight, the classical reverse cholesterol transport concepts are discussed and the subject reverse cholesterol transport is revisited.

Keywords: Cholesterol, Reverse cholesterol transport, Transintestinal cholesterol efflux, Liver, Intestine, Lipoproteins

FROM THE EDITOR

Cholesterol is of vital importance for all vertebrates. It is an essential structural component of cell membranes. In addition, cholesterol is needed for the manufacture of bile salts, steroid hormones and vitamin D. However, too much cholesterol is harmful. A high level of serum cholesterol is a risk factor for certain cardiovascular diseases. Fortunately, the body possess a transport route in order to dispose cholesterol: reverse cholesterol transport, which is an interesting target for drug development aiming at the treatment/prevention of atherosclerotic and associated diseases. Since the introduction of reverse cholesterol transport in the 1970s, this pathway has been intensively investigated.

The thorough research on reverse cholesterol transport has led to a great understanding about the way cholesterol is disposed. However, new insights in cholesterol excretion were rendered as well. Insights make the classical view on reverse cholesterol transport questionable. In this topic highlight, the classical reverse cholesterol transport concepts are discussed and the subject reverse cholesterol transport is revisited[1-7].

Footnotes

S- Editor Cheng JX L- Editor Wang XL E- Editor Zheng XM

References

1. van der Velde AE. Reverse cholesterol transport: From classical view to new insights. World J Gastroenterol. 2010;16:5908–5915. [PMC free article] [PubMed]
2. Hoekstra M, Van Berkel TJC, Van Eck M. Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism. World J Gastroenterol. 2010;16:5916–5924. [PMC free article] [PubMed]
3. Vantourout P, Radojkovic C, Lichtenstein L, Pons V, Champagne E, Martinez LO. Ecto-F1-ATPase: A moonlighting protein complex and an unexpected apoA-I receptor. World J Gastroenterol. 2010;16:5925–5935. [PMC free article] [PubMed]
4. Dikkers A, Tietge UJF. Biliary cholesterol secretion: More than a simple ABC. World J Gastroenterol. 2010;16:5936–5945. [PMC free article] [PubMed]
5. Temel RE, Brown JM. A new framework for reverse cholesterol transport: Non-biliary contributions to reverse cholesterol transport. World J Gastroenterol. 2010;16:5946–5952. [PMC free article] [PubMed]
6. Vrins CLJ. From blood to gut: Direct secretion of cholesterol via transintestinal cholesterol efflux. World J Gastroenterol. 2010;16:5953–5957. [PMC free article] [PubMed]
7. Pedrelli M, Pramfalk C, Parini P. Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport. World J Gastroenterol. 2010;16:5958–5964. [PMC free article] [PubMed]

Articles from World Journal of Gastroenterology are provided here courtesy of Baishideng Publishing Group Inc