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Nucleic Acids Res. 2010 December; 38(22): iii.
Published online 2010 December 11. doi:  10.1093/nar/gkq1311
PMCID: PMC3001048


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Cover: Cap Analysis of Gene Expression (CAGE) measures the expression at promoters in a genome wide fashion. In combination with siRNA driven knockdown of transcription factors, we can observe expression changes in promoters which are likely to be regulated by individual factors. In turn this allows us to derive transcription factor binding motifs and construct directional promoter based gene expression networks. Graphic design by Kazufumi Watanabe.
For further information, please see the article by Vitezic et al., Nucleic Acids Res., 2010, 38, 8141–8148.

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press