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Correspondence to: Serafino Fazio, MD, Department of Internal Medicine, Cardiovascular and Immunologic Sciences, University of Naples Federico II School of Medicine, via S. Pansini 5, 80131 Naples, Italy. ti.aninu@oizaf
Telephone: +39-81-7463737 Fax: +39-81-7463737
We report the long-term follow-up of 3 cases of severe idiopathic pulmonary arterial hypertension, in whom tadalafil plus sitaxentan combination therapy improved the clinical condition and exercise performance without any relevant adverse event.
Pulmonary arterial hypertension (PAH) is a devastating disease with a median life expectancy, without appropriate therapy, of 2.8 years from diagnosis. The better understanding of the pathologic processes responsible for the increase of pulmonary vascular resistance in PAH has led, in the past 10 years, to the development of new oral substances that have significantly improved the prognosis and the quality of life (QoL) of PAH patients. The 3 main mechanisms involved in the pathogenesis of PAH are vasoconstriction, proliferation and remodeling of the pulmonary arteries, and thrombosis. An imbalance among key neurohormonal mediators leads to the progression of the disease. Oral drugs are now available, targeting the different pathways involved in the pathobiology of PAH; it appears therefore likely that a prompt combination approach in the treatment of the disease may result in a synergistic action, with consequent slowing of disease progression and improvement of prognosis. However, the role and exact timing of initiation of multiple drug therapy are still debated.
Tadalafil is a long-acting phosphodiesterase type-5 inhibitor. By increasing the levels of cGMP, the final mediator in the nitric oxide pathway, tadalafil exerts vasodilatatory and antiproliferative effects on pulmonary vascular smooth cells. Although only recently approved in Europe for PAH, tadalafil has proven to improve exercise capacity and QoL in patients[3,4]. Endothelin-1 is a potent endothelium-derived vasoconstrictor peptide endowed with mitogenic properties. Its overexpression in PAH can be counteracted by endothelin receptor antagonists. Sitaxentan is an approved selective endothelin receptor antagonist that is selective for ETA over ETB receptors and has about a 6000-fold higher affinity than non-selective endothelin receptor antagonists. It is also associated with a lower incidence of hepatic abnormalities, and with a comparable improvement in the 6-min walking test.
As a result of their long half lives, both tadalafil and sitaxentan can be administered once a day. In addition, they are not associated with the pharmacokinetic interactions reported with other combinations of the same drug classes.
Three patients with severe idiopathic PAH, assessed by right heart catheterization (baseline data shown in Table Table1),1), had been treated for 1 year with tadalafil 40 mg/d. Subsequently, an oral dose of sitaxentan 100 mg was added to the therapy. All patients had negative coronary angiograms and no segmental defects on a lung perfusion scan. While patient 1 had longstanding disease, both patients 2 and 3 had been diagnosed within 1 year of the start of tadalafil therapy.
Clinical status, exercise capacity, QoL, vascular reactivity [measured by flow-mediated dilation (FMD)], diffusion capacity of the lung (DLCO), Doppler PA pressure estimates and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were assessed at baseline (T0), after 1 year of therapy with tadalafil alone (T1), after 6 mo of treatment with a combination of tadalafil plus sitaxentan (T2) and after 12 mo follow-up of combined therapy (T3). Liver function tests and hemoglobin were evaluated monthly. Patients also received supportive therapy, as indicated, including warfarin, digoxin, furosemide, and supplemental O2. Adverse events were monitored throughout the period.
After 1 year of treatment with tadalafil, the 3 patients showed a clear improvement in their clinical condition, exercise capacity and QoL (Table (Table1).1). Subsequently, sitaxentan (100 mg/d) was added to the tadalafil treatment, despite the stable clinical conditions and the improvement of pulmonary pressure. The combination was well tolerated and, after 6 mo, there was an additional improvement in the patients’ clinical status, exercise capacity, DLCO, FMD, WHO functional class, QoL, NT-proBNP levels and estimated PA pressure (Table (Table1).1). After 12 mo, patient 2 deteriorated to WHO class IV and was promptly started on epoprostenol therapy, with good clinical and hemodynamic response. In this patient, sitaxentan was withheld, while tadalafil therapy was continued. Patient 3 improved further, whereas patient 1 remained stable. No adverse event and no hemoglobin or liver enzyme abnormalities were recorded. As recommended, when initiating sitaxentan, doses of warfarin were halved in all 3 patients.
Invasive follow-up of hemodynamics was not performed because of objective and subjective symptomatic improvement and satisfactory Doppler-echocardiographic measurements, in a “clinical strategy” approach. Interestingly, measurements of vascular reactivity by means of FMD correlated well with clinical benefit and changes in NT-proBNP in the 3 subjects.
The results obtained in our 3 patients affected by severe idiopathic PAH show that an ab initio combination treatment strategy might be effective, well tolerated and safe in the long-term. To our knowledge, only one case series has been published to date on this combination therapy. In fact, the combination of tadalafil and sitaxentan improved QoL and exercise capacity in these patients, and, because of the simple dose schedule, the compliance was very good, and no side effects were recorded.
There is an ongoing debate as to whether to initiate patients with PAH directly on combined therapy or to wait for clinical deterioration. The recent guidelines from the 4th World Conference on Pulmonary Hypertension report that a combinative approach may be proposed only when the clinical response to monotherapy is not adequate. However, clinical studies suggest that delaying the start of therapy may lead to a loss of efficacy with respect to prompt therapy, and, probably, this could be considered particularly true in a combination strategy. We believe that early treatment with a combination of 2 or more drugs, acting on different pathologic pathways at the base of the disease, could prevent or slow the further progression, limiting the costs in terms of clinical worsening; we look forward to the results of large controlled trials exploring this intriguing hypothesis with a more powerful study design.
Peer reviewers: Dirk Skowasch, MD, Department of Cardiology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany; Juan C Grignola, PhD, Department of Pathophysiology, Hospital de Clinicas, Facultad de Medicina, Universidad de la República. Avda Italia s/n, Piso 15. Montevideo, PC 11600, Uruguay
S- Editor Cheng JX L- Editor Cant MR E- Editor Zheng XM