I read with great interest a recent published work on triphala mouthwash by Tandon et al They concluded that there was no significant difference between triphala and chlorhexidine mouthwashes. I agree that this work confirms the dental usefulness of triphala. The previous report also mentioned the counteraction on biofilm formed on tooth substrate. However, there are some facts on the triphala to be known. Triphala has been recently reported to have an in vitro effect on drug modulating enzymes. Disturbance on cytochrome P450 is mentioned, thereby the likelihood of herb–drug interactions, if these are administered concomitantly, can be expected.