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Indian J Ophthalmol. 2010 Nov-Dec; 58(6): 551.
PMCID: PMC2993999

Authors’ reply

Dear Editor,

First, we appreciate the details with which Chalisgaonkar et al.[1] have read our case report[2] and searched the literature of retinoblasotoma in adults.

In the case report by Biswas et al.,[3] on the computed tomogram (CT), ’a speck of calcification’ was noted. No gross calcified areas were found. In the remaining cases no calcification was noted.

In all case reports of retinoblastoma in adults, retinocytoma was diagnosed as benign appearing areas in malignant tumor tissue and not as pre-existing lesions that turned malignant on follow-up.[4] In our case no such benign appearing cells were noted in the malignant tissue, in the multiple tissue sections that were taken.[1]

Ours is the only case reported in literature where retinoblastoma was found in pregnancy. There is one case reported by Takahashi et al.,[5] six months postpartum. We have stated that new cases and further study is needed for establishing this relationship. Pregnancy may have an effect on retinoblastoma due to circulating mutagens and immunosuppression.[6]


1. Chalisgoankar C, Rathore MK, Dwivedi PK, Choudhay P, Lakhtakia S, Sharma K. Retinoblastoma in Pregnancy. Indian J Ophthalmol. 2010;58:550. [PMC free article] [PubMed]
2. Nandedkar VS, Joshi AR, Kabra N, Deshpande NN. Presentation of retinoblastoma in pregnancy. Indian J Ophthalmol. 2010;58:229–32. [PMC free article] [PubMed]
3. Biswas J, Mani B, Shanmugan MP, Patwardhan D, Kumar KS, Badrinath SS. Retinoblastoma in adults: Report of three cases and review of literature. Surv Ophthalmol. 2000;44:409–14. [PubMed]
4. Odashiro AN, Pereira PR, de Souza Filho JP, Cruess SR, Burnier MN., Jr Retinoblastoma in an adult: Case report and literature review. Can J Ophthalmol. 2005;40:188–91. [PubMed]
5. Takahashi T, Tamura S, Inoue M, Isayama Y, Sashikata T. Retinoblastoma in a 26-year-old adult. Ophthalmology. 1983;90:179–83. [PubMed]
6. Antonelli NM, Dotters DJ, Katz VL, Kuller JA. Cancer in pregnancy: A review of literature. Obstet Gynecol Surv. 1996;51:125–34. [PubMed]

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