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I read the article by Sudharshan et al., which describes the current approach in posterior uveitis. I would like to congratulate the authors for an excellent comprehensive review and to add a few comments about autofluorescence (AF) in various posterior uveitic conditions.
The amount of AF is determined by the amount of fluorophores, which varies during the acute and resolution phases of inflammation. Hypertrophy and reactive hyperplasia of retinal pigment epithelium (RPE) is associated with increase in AF, due to accumulation of flurophores. A transmission defect during fundus fluorescein angiography (FFA), because of RPE atrophy, appears to be hypo-autofluorescencent.
Following are the important AF findings reported in various chorioretinal inflammatory conditions: