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Integrins are integral on dendritic cells
Illustration of a dendritic cell, the main antigen-presenting cell of the immune system. In the current issue, two studies show that integrins on DCs are essential for triggering the differentiation of Th17 cells, key regulators of inflammatory and autoimmune disease (page 4436 and page 4445). In fact, in animals in which αv integrins on DCs were absent, Th17 cells could not be generated, and the mice were protected from developing EAE.