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I read the recent publication on rapid determination of paeoniflorin with great interest. Zhou et al. concluded that their new proposed method is a rapid, effective, binary reverse phase rapid resolution liquid chromatographic (LC) method. I have some comments on this work. First, I have a concern on the cost of this new LC method. Is it expensive that prevents it from application in routine usage? Second, the quality management, especially for external quality assessment, is a problem that might prevent the generalization of this new technique. Third, the LC is not the fastest technique for identification. Fluorescence- and electrochemical-based detections might be faster.