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Logo of agpsychBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleAnnals of General Psychiatry
Ann Gen Psychiatry. 2010; 9(Suppl 1): S23.
Published online 2010 April 22. doi:  10.1186/1744-859X-9-S1-S23
PMCID: PMC2991925

The pharmacotherapy of depression with EPA

This lecture considers the pharmacotherapy of depression with EPA under the following headings:

• Epidemiological evidence

• Biochemical evidence

• First trial of pure EPA in severe treatment-resistant depression

• Subsequent randomized double-blind placebo-controlled trials

• Putative mechanisms.

Results obtained from our own group, including structural neuroimaging and 31-phosphorus neurospectroscopy findings, showing an association of EPA treatment of depression with a marked decrease in cerebral phosphodiesters, a marked increase in cerebral phosphomonoesters and reduced lateral ventricular volume, will also be presented.

Articles from Annals of General Psychiatry are provided here courtesy of BioMed Central