PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of agpsychBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleAnnals of General Psychiatry
 
Ann Gen Psychiatry. 2010; 9(Suppl 1): S182.
Published online 2010 April 22. doi:  10.1186/1744-859X-9-S1-S182
PMCID: PMC2991872

Possible correlations between the psychological state and excessive innate immunity responses in ulcerative colitis

Background

Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), belong to the autoimmune disorders in the sense that an excessive response of the immune system(both innate and acquired) towards commensal microbial flora of the intestinal mucosa is involved in their pathogenesis. The progress of IBD is unknown, characterized by periods of exacerbation and quiescence. Depression and anxiety seem to coincide with relapse of IBD and further research is needed for the clarification of this correlation.

Aim

To further investigate the relationship between the psychological state of UCpatients and the gravity of their biopsy during relapse.

Materials and methods

29 UC patients, hospitalized in two general hospitals for the investigation of a possible relapse of their disease were examined. Methods: Four self- report inventories (Hospital Anxiety and Depression Scale-HADS, Zung Depression Scale, State Trait Anxiety Inventory Form1 and Form 2/STAI1/STAI2) were administered to the patients and the scores were correlated with the severity of parameters of their corresponding biopsies.

Results

Positive correlations were observed between the degree of anxiety and depression in the questionnaires and the activation of innate immunity (polymorphonuclear leucocytes and macrophages) in the biopsies of UC patients

Conclusions

Our findings suggest correlations between the psychological state of UC patients and the intensity of their innate immune response perpetuating inflammation.

References

  • Shih DQ, Targan SR, McGovern D. Recent advances in IBD pathogenesis: genetics and immunobiology. Curr Gastroenterol Rep. 2008;10(6):568–75. doi: 10.1007/s11894-008-0104-x. [PMC free article] [PubMed] [Cross Ref]
  • Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review. Inflamm Bowel Dis. 2007;13(2):225–34. doi: 10.1002/ibd.20062. [PubMed] [Cross Ref]
  • Hisamatsu T, Ogata H, Hibi T. Innate immunity in inflammatory bowel disease: state of the art. Curr Opin Gastroenterol. 2008;24(4):448–454. doi: 10.1097/MOG.0b013e3282ff8b0c. [PubMed] [Cross Ref]

Articles from Annals of General Psychiatry are provided here courtesy of BioMed Central