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Logo of agpsychBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleAnnals of General Psychiatry
Ann Gen Psychiatry. 2010; 9(Suppl 1): S125.
Published online 2010 April 22. doi:  10.1186/1744-859X-9-S1-S125
PMCID: PMC2991809

Relationship of parental age with set shifting and reversal learning in schizophrenia


Advanced parental age at birth has been associated with the risk of schizophrenia and has been linked to cognitive deficits in children. However, the relationship of parental age with cognition and with attentional flexibility in schizophrenia remains unknown.

Materials and methods

27 patients with schizophrenia, were tested on the intra-dimensional/extra-dimensional set-shifting task (IEDS) of the Cambridge Neuropsychological Test Automated Battery (CANTAB) in an acute psychiatric ward. The paternal (PAB) and maternal age at birth (MAB) were also registered. Statistical correlation analyses and the Mann-Whitney test were performed using the SPSS.


PAB positively correlated with the intra-dimensional shifting errors in the IEDS (rho = 0.7, p = 0.005). MAB positively correlated with both intra- and extra-dimensional reversal errors (rho = 0.572, p = 0.026 and rho = 0.9, p = 0.037, respectively). When we divided our subjects into two groups according to their PAB (≥ and < 30 years), no differences were found in any cognitive measure. However, the group with a MAB ≥ 30 years, showed increased intra-dimensional reversal errors compared with the group with a MAB < 30 years (p = 0.03 and 0.029 respectively).


Increasing parental PAB showed an inverse relationship with the intra-dimensional shifting ability, but did not affect rule reversal performance. MAB was associated with errors in both intra- and extra-dimensional reversal in schizophrenia.


  • Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser ES. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry. 2001;58(4):361–7. doi: 10.1001/archpsyc.58.4.361. [PubMed] [Cross Ref]
  • Saha S, Barnett AG, Foldi C, Burne TH, Eyles DW, Buka SL, McGrath JJ. Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood. PLoS Med. 2009;10,6(3):e40. doi: 10.1371/journal.pmed.1000040. [PMC free article] [PubMed] [Cross Ref]

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