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Middle East Afr J Ophthalmol. 2010 Oct-Dec; 17(4): 390.
PMCID: PMC2991465

Ophthalmic Disorders in Adult Lymphoma Patients


We read with great interest the article by Omoti et al.1 on the spectrum of ophthalmic disorders in adult patients with lymphoma. The article has systematically covered a wide variety of ophthalmic disorders.

However, we do not completely agree with the authors’ contention that most reports of ocular involvement in lymphoma involve few patients. Cassoux et al.2 reported 42 cases and Hormigo et al.3 reported 31 cases of primary intraocular lymphoma in their respective study cohorts. Similarly, Shields et al.4 and Coupland et al.5 reported 117 and 37 cases, respectively, of conjunctival involvement in lymphoma.

The authors have comprehensively documented the ocular and adnexal involvement in a series of patients with systemic lymphomas. It would also be of interest to the ophthalmologists to look at it from the other point of view. Shields et al.4 analyzed a large series of conjunctival lymphomas and found that 31% of them are associated with systemic lymphomas. Demirci and coworkers 6,7 in a large series of 160 patients noted that 25% had systemic association with orbital lymphomas, and more interestingly documented that 33% of orbital lymphomas at presentation subsequently developed systemic lymphomas over 10 years.

Omoti et al.1 excluded all the patients on treatment in their analysis. It could have been possible to still elucidate ocular findings in at least some of these patients which would have further contributed to our understanding of lymphomas.

The article also presents three cases of presumed lymphoma-associated retinopathy based only on features of hemorrhages and vasculitis. Although possible, we believe that angiocentric lymphomas are extremely rare and the classic presentation would be in the form of confluent, round, or geographic greasy-yellow subretinal pigment epithelium infiltrates. 8


1. Omoti AE, Omoti CE, Momoh RO. Ophthalmic disorders in adult lymphoma patients in Africa. Middle East Afr J Ophthalmol. 2009;16:252–5. [PMC free article] [PubMed]
2. Cassoux N, Merle-Beral H, Leblond V, Bodaghi B, Miléa D, Gerber S, et al. Ocular and central nervous system lymphoma: Clinical features and diagnosis. Ocul Immunol Inflamm. 2000;8:243–50. [PubMed]
3. Hormigo A, Abrey L, Heinemann MH, DeAngelis LM. Ocular presentation of primary central nervous system lymphoma: Diagnosis and treatment. Br J Haematol. 2004;126:202–8. [PubMed]
4. Shields CL, Shields JA, Carvalho C, Rundle P, Smith AF. Conjunctival lymphoid tumors: Clinical analysis of 117 cases and relationship to systemic lymphomas. Ophthalmology. 2001;108:979–84. [PubMed]
5. Coupland SE, Krause L, Delecluse HJ, Anagnostopoulos I, Foss HD, Hummel M, et al. Lymphoproliferative lesion of ocular adnexa. Analysis of 112 cases. Ophthalmology. 1998;105:1430–41. [PubMed]
6. Demirci H, Shields CL, Shields JA, Honavar SG, Mercado GJ, Tovilla JC. Orbital tumors in older adult population. Ophthalmology. 2002;109:243–8. [PubMed]
7. Demirci H, Shields CL, Karatza EC, Shields JA. Orbital lymphoproliferative tumors: Analysis of clinical features and systemic involvement in 160 cases. Ophthalmology. 2008;115:1626–31. [PubMed]
8. Dean JM, Novak MA, Chan CC, Green WR. Tumor detatchments of the retinal pigment epithelium in ocular or central nervous system lymphoma. Retina. 1996;16:47–56. [PubMed]

Articles from Middle East African Journal of Ophthalmology are provided here courtesy of Wolters Kluwer -- Medknow Publications