Effect of Fungal Burdens on MKP1 and c-Fos Activation
(A and B) Induction of (A) MKP1 phosphorylation and (B) c-Fos DNA binding activity by differing fungal burdens. An MOI of 1 or higher is required to activate the second MAPK phase. Wild-type SC5314 C. albicans was added as yeast cells at each MOI, and infections were left for (A) 2 hr or (B) 3 hr in each case. Data are representative of three independent experiments.