Effects of targeted deletion of Rb1 in pituitary IL and AL of Skp2+/+ and Skp2-/- mice. a. The POMC-Cre strain induced Cre-loxP-mediated excision in PL and AL of Skp2+/+ and Skp2-/- mice. Rosa26R, Rosa26-loxP-STOP-loxP-EYFP. Mice were examined at 4 weeks of age. EYFP expression was by fluorescence of frozen-sectioned samples. b. Pituitary ILs of indicated mice at 7 weeks of ages. H&E stained sections of various pituitaries are shown. Big insert is enlarged view of areas marked by the small box. c. Pituitary glands of the indicated mice at the indicated ages, examined as in panel a. Scale bar, 200 μm.