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Cancer Microenviron. 2010 December; 3(1): 107.
Published online 2010 October 12. doi:  10.1007/s12307-010-0054-3
PMCID: PMC2990489


The past 10 years have seen remarkable progress in the research, diagnosis, and therapy of gastrointestinal cancer. It has been shown that the development, invasion and metastasis of gastric and colorectal cancers require multi-step cascading process in the complex interaction between cancer cells and stromal cells in tumor microenvironment. This special issue, “Cancer-Stromal Interaction in Gastrointestinal Cancer” brings together the most recent information on carcinogenesis, biology, stem cells, progression, angiogenesis, productive fibrosis, and roles of microRNAs in tumor invasion of gastrointestinal cancer, with contribution by renowned researchers. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastrointestinal cancer.

Articles from Cancer Microenvironment are provided here courtesy of Springer Science+Business Media B.V.