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F1000 Med Rep. 2010; 2: 64.
Published online 2010 August 19. doi:  10.3410/M2-64
PMCID: PMC2990449

Relationships between mild traumatic brain injury sustained in combat and post-traumatic stress disorder


The setting of the trauma is a distinguishing feature between mild traumatic brain injury (mTBI; also called concussion) that occurs in civilian settings compared with that occurring in combat. Combat mTBI is frequently associated with a prolonged stress reaction, post-traumatic stress disorder (PTSD). Individuals with mTBI and PTSD from combat in Operations Iraqi Freedom and Enduring Freedom often develop prolonged post-concussion symptoms (PCSs) such as headache. Both mTBI and PTSD may contribute to PCSs. PTSD may worsen and prolong the PCSs following mTBI by disrupting sleep. It is not known how mTBI predisposes an individual to develop PTSD.

Introduction and context

Mild traumatic brain injury (mTBI) is common among military personnel and veterans who served in Operations Iraqi Freedom and Enduring Freedom (OIF/OEF). Among soldiers deployed in OIF, 22.8% had traumatic brain injury (TBI), predominantly mTBI [1]. While there is a general opinion that the prevalence of post-traumatic headaches is higher in association with combat mTBI than with mTBI sustained in a civilian setting [2], the data are not conclusive. A prospective controlled study of headaches in civilians who had traumatic injury compared 100 sequential patients with mTBI and 100 matched minor injury controls who had non-deceleration injuries; 15% of those with mTBI had persistent post-traumatic headache at 3 months compared to 2% of the minor non-TBI injury controls [3]. In contrast, a study of 340 OIF/OEF veterans found that 55% of the veterans had headaches when evaluated typically more than a year after the combat TBI [4]. Another study of 155 OIF/OEF veterans with combat mTBI found that 52% of the veterans had headaches that persisted for years after the last episode of TBI [5]. The differences in the prevalence of headaches may be partly due to differences in sampling. The veterans in the two prior studies were receiving care from the Department of Veterans Affairs, but not all veterans elect to receive care from the Department of Veterans Affairs. It is possible that the veterans in the prior study represent enriched samples of veterans with medical issues. Therefore, the veteran studies may over-represent the prevalence of headache. In a brigade combat team that was deployed in Iraq for 1 year, 22.8% of soldiers had a physician-confirmed TBI, usually mTBI [1]. Among the soldiers with TBI, 81.3% reported headaches immediately after the TBI and 20.3% reported headaches after the deployment. In another military study of headaches among 5270 soldiers returning from an OIF/OEF deployment, 1033 (19.6%) had combat concussions, and among the group with mTBI, 97.8% reported headaches during the last 3 months of their deployment [6]. The differences in prevalence of post-traumatic headaches based upon the first military study - 20.3% (combat) versus 15% (civilian) - is not significant, but the headache prevalence of 97.8% noted in the second study would have significantly exceeded the 15% prevalence found in civilians. The second study considered all headaches that occurred following TBI, with 42% of the post-traumatic headaches beginning more than 1 month after TBI. Even if one only considered the prevalence of headache that began within 1 month of TBI in this study (57%), this would still have been significantly greater than the 15% civilian prevalence (P < 0.001). Therefore, due to the variations in the findings of the military studies, it is uncertain whether post-traumatic headaches are more prevalent following combat mTBI.

The study of the brigade combat team revealed that, after deployment, 39% of soldiers with TBI reported persistent post-concussion symptoms (PCSs) [1] and the military study of 5270 soldiers, also discussed above, found that at least 98% of soldiers had PCSs in the last 3 months of deployment [6]. Veterans with combat mTBI may have persisting PCSs for several reasons. The US Institute of Medicine recently reported an association between mTBI and the development of post-traumatic stress disorder (PTSD) for OIF/OEF military personnel [2]. Combat TBI occurs in situations likely to induce PTSD and those at risk for combat TBI are often exposed to many other psychologically traumatic events, such as injury or death of fellow soldiers as well as being under constant threat to their own lives [7-9]. Symptoms associated with PTSD overlap with PCSs (Figure 1) so that some PCSs may be due to co-existent PTSD [4,8-10]. Combat mTBI usually does not remove military personnel from combat. Consequently, soldiers with mTBI can be returned quickly to combat stress, which will preclude a rest period that might aid recovery from mTBI [7].

Figure 1.
Overlap of symptoms associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD)

mTBI appears to increase the risk of developing PTSD. In a civilian study, the prevalence of PTSD following mTBI was 6%, which was about 1.9-fold higher (odds ratio = 1.92, 95% confidence interval = 1.08-3.40) than following trauma without mTBI [11]. The reported prevalence of PTSD following combat mTBI appears to be greater than after civilian mTBI. About 40% of military personnel and veterans with combat-acquired mTBI have co-existent PTSD [4,10,12]. Among active duty military personnel deployed in Iraq (OIF) who had an episode of loss of consciousness, 43.9% had PTSD compared with 16.2% for soldiers with other injuries and 9.1% for soldiers with no injury [8]. Another study of 277 OIF/OEF veterans found that 18.8% had mTBI and that the veterans with mTBI were more likely to have PTSD than veterans who did not have mTBI [13]. While these findings suggest that mTBI increases the likelihood of PTSD, they do not clarify the mechanisms.

Soldiers with mTBI were more likely to report persisting PCSs than were soldiers with other injuries [8,13]. Hoge et al. [8,14] argue that the PCSs are due to PTSD and depression, not mTBI. However, against this argument is the observation that 69% of veterans with mTBI who have PCSs have neurological abnormalities on clinical examination [5]. In addition, a recent study [15] of OIF/OEF veterans with mTBI who had PCSs (with or without PTSD) reported that they exhibited decreased cerebral metabolic rate of glucose in the cerebellum, pons, and medial temporal lobe. They also had subtle impairments in verbal fluency, cognitive processing speed, attention, and working memory, similar to those reported in the literature for patients with cerebellar lesions. The deficits in cerebellar metabolism and cognitive performance were felt by the authors to be manifestations of brain injury rather than PTSD and the cerebellum has not been noted to be a locus of abnormality in studies of individuals with PTSD without TBI (see below). The presence of abnormalities on neurological examination, brain metabolism, and cognitive testing suggest that veterans with mTBI and PCSs can have persistent brain injury. Therefore, it may be more prudent to consider that both the PTSD and persisting brain injury are contributing to the PCSs. Figure 1 illustrates the overlap of symptoms associated with mTBI and PTSD. Either persisting brain injury or PTSD could produce many of the PCSs.

Recent advances

Recent imaging studies have identified brain functions or structures associated with mTBI. Abnormalities in white matter can be seen in individuals with mTBI using magnetic resonance imaging techniques such as diffusion tensor imaging. The white matter changes reflect axonal injury due to mTBI [16,17]. The extent of axonal injury is related to TBI severity, with severe TBI having more extensive axonal injury [18]. Additionally, individuals with mTBI can manifest abnormal foci of neuronal activity or cerebral blood flow. Loci of injury or abnormal cerebral metabolism include the inferior medial frontal lobes, medial temporal lobes, occipital cortex, and cerebellum [7,15,16,19-22].

In individuals without TBI, PTSD is associated with abnormal cerebral activity involving the inferior frontal lobes and anterior medial temporal lobes [16,20,23,24]. The areas of abnormal cerebral activity in the frontal and medial temporal lobes seen in PTSD overlap with the loci of injury identified in individuals with mTBI. Therefore, the cerebral injury associated with mTBI may potentiate the development of PTSD in response to a traumatic event.

The likelihood of an individual developing PTSD is influenced by many factors, including the character of the traumatic exposure and the individual's psychological resiliency and educational history [25]. Although the physiological connections between mTBI and the genesis of PTSD have not been elucidated, studies of military combat mTBI [8,13,26] and adult civilian TBI [11] indicate that PTSD is associated with mTBI (Figure 2). A study of civilian children involved in motor vehicle accidents did not find an association between mTBI and PTSD [27]. Cognitive impairment due to TBI may increase the risk for an individual to develop PTSD by compromising their ability to psychologically adjust to a traumatic event [28].

Figure 2.
Traumatic brain injury (TBI) may influence the development of post-traumatic stress disorder (PTSD) following a traumatic event

There are several reasons why mTBI acquired in combat may be more likely to produce longer lasting or more persistent cerebral injury than civilian-acquired mTBI. Military personnel in OIF/OEF often experience multiple mTBI events [5,7,15,29], creating the possibility of accumulation of injury [2,7]. The most common cause for combat mTBI was exposure to an explosion. Combat TBI caused by a blast is often associated with two almost simultaneous traumatic events to the brain. In combat, military personnel are often close enough to an explosion to experience the pressure wave. In addition, military personnel often experience additional head trauma from the explosion due to being thrown by the blast-wind, being impacted by shrapnel, or being involved in a motor vehicle accident associated with the explosion [7].

The PCSs associated with combat mTBI differ from those associated with civilian mTBI. Civilian mTBI is usually associated with tension-type headaches, whereas the headaches reported following combat mTBI are more likely to have migraine features [5,6,30]. The co-existence of mTBI and PTSD, which is frequently seen with combat mTBI, appears to increase the severity of PCSs and the number of PCSs that are endorsed [31-33].

Impaired sleep due to PTSD may be partially responsible for the prolonged PCSs. Interrupted sleep due to nightmares is common in veterans with mTBI and PTSD [29,33]. Prazosin successfully blocks nightmares and other sleep interruptions caused by PTSD [34,35]. In an observational study of OIF/OEF veterans with mTBI due to combat explosions, prazosin treatment combined with sleep hygiene counseling was able to reduce PCS and improve cognitive functioning [29].

Implications for clinical practice

Combat mTBI is not an isolated condition; it is often associated with PTSD and pain, particularly headaches with migraine features [4,10]. It is critical to address the residual brain injury, pain, and psychological manifestations of PTSD. Increasing evidence indicates that impaired sleep will exacerbate pain disorders such as PCSs [36]. Thus, improving sleep may be a good initial step in treating PCSs due to mTBI and PTSD. In the aforementioned observational study, the combination of prazosin and sleep hygiene counseling was highly efficacious and well accepted by OIF/OEF veterans [29].


The authors are supported by the Department of Veterans Affairs and the National Institutes of Health.


mild traumatic brain injury
Operations Iraqi Freedom and Enduring Freedom
post-concussion symptom
post-traumatic stress disorder
traumatic brain injury


The electronic version of this article is the complete one and can be found at:


Competing Interests

The authors declare that they have no competing interests.


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