Writing committee: Jane Armitage, Louise Bowman, Karl Wallendszus, Richard Bulbulia, Kazem Rahimi, Richard Haynes, Sarah Parish, Richard Peto, Rory Collins.
Steering committee: T Meade and P Sleight (co-chairs), R Collins and J Armitage (principal investigators), L Bowman (clinical coordinator), S Parish and R Peto (statisticians), J Barton, C Bray, E Wincott, R Dayanandan (administrative coordinators), R Clarke, I Graham, D Simpson, C Warlow, D Wilken (expert advisors); and J Tobert and T Musliner (Merck observers).
Data monitoring committee: R Doll (chair; died 2005), L Wilhelmsen (vice-chair and then chair from 2005), K Fox, C Hill, P Sandercock.
Aberdeen Royal J Webster, J Henderson, A Nixon, S Lackie, J Thompson; Addenbrooke's M Brown, S Blackwood, M Morgan; Barnsley District General W Rhoden (deceased), B Saeed, M Houghton, A Nicholson, C Simpson, B Hoburn; Bedford I Cooper, A Gallivan, E Pickerell, J Hancock, J Watkinson; Birmingham City B Ryder, S Jones, W Burbridge, M Kitchen, H O'Leary, C Verow, L Meynell, L Rollinson; Birmingham Heartlands S Bain, A Jones, C Jewkes, C Russon; Bishop Auckland General M Bateson, P Gill, J Nicol; Bristol Royal G Bayly, D Stansbie, G Andrews, M Halestrap, J Meredith; Burnley General R Best, D Appleyard, R Briggs, H Wareing, K Holmes, J Holt, M Kenyon; Castleford & Normanton C White, M Khalifa, D Newton, A Wass, R Watkinson; City General, Stoke-on-Trent J Creamer, S Anderson, A Bethell, C Butler, K Castro, M Washington, M Weston, K Cleaver, J Machin; Conquest, Hastings R Wray, J Sinclair, A Van Aalst; Coventry and Warwickshire M Been, R Mattu, D Bates, A Burke, L Gill, E Walton; Cumberland M Cowley, H Robson, A Graham, G Rose, M Kerr, J Mallinson, B Peascod; Derbyshire Royal R Donnelly, J Kalk, A Scott, T Gibson, J Hannah, L Henshaw, M Margetts, N Pearson, S Frost, S Murray; Derriford A Marshall, J Went, A Inman, J Simmonds, A Teasdale; Dewsbury T Kemp, G Roberts; Ealing J Kooner, S Cahill, M Lloyd, O Molloy, J Wigley, M Galvin, C Wilder; Edinburgh Royal R Lindley, S Shaw, C Swainson, L Hillis, J Johnston, A Johnstone, D Miller, M Kennedy; Fairfield, Bury S Mushahwar, M Savage, D Appleyard, G Ayer, J Schofield, S Greenhalgh, J Parks, S Speak; Frenchay, Bristol C Coulson, M Papouchado, R Carpenter, J Wisby; Glasgow Royal S Cobbe, C Campbell, J Hunter, H Young, M Gallacher; Gloucestershire Royal D Lindsay, A Halliday, S Godfrey, L O'Donahoo; Guy's & St Thomas' J Chambers, A Wierzbicki, A Jones, D Parkin, K Nwafor; Hairmyres, Glasgow K Oldroyd, B Vallance, N Cunningham, G Moreland, C Oldroyd, H Young, M Crawford; Hillingdon R Hillson, K Knott, N Mahabir, A Crouch, Y MacDonald; HM Stanley, St Asaph C Bellamy, J Green, L Brown, J Heron, N Jones, M Roberts, D Hainsworth, J Williams; Hope Hospital, Salford P Barnes, A Fitchet, C Longworth, J Davidson; Ipswich N Irvine, R Oliver, C Pond, M Nuttall; King's Mill, Sutton-in-Ashfield R Lloyd-Mostyn, M Brown, J Barrowcliffe, S Blackburn, W Furnell, S Webster, L Wheatley; Leicester General I Hudson, J Pohl, S Nicholson; Leighton, Crewe S Mallya, M Nash, J Spruce, A Bonner, J Leather, A Searle; Macclesfield E Davies, R Egdell, B Price, A Taylor Bennett, S Horton; Manor, Walsall A Cunnington, P Giles, J Sidaway, L Tomlinson, E Walton, L Hawkins, J Long; Memorial, Darlington J Murphy, G Brennan, M Boon, S Cassidy; Monklands, Airdrie C Rodger, J Hunter, A McNeilly, G Moreland, A Radcliffe; Monkwearmouth, Sunderland M Farrer, J Bluett, L Cowell, A Farrell, S Gilroy, S Warren; Musgrove Park, Taunton T MacConnell, S Burtchaell, L Williams; New Cross, Wolverhampton P Rylance, A Hodgson, K Kertland-Hill, L Robinson, A Smallwood, S Lomas; Newton Hospital, St Helens J Ball, S Benbow, K Hardy, M Gerrard, C Langley, M Beattie, C Fagan; Ninewells, Dundee B Green, T Pringle (deceased), H Hanna, A Mackintosh, E Watson; North Manchester General J Swan, D Appleyard, D McSorland, G Thompson, C O'Neill; North Tyneside General R Curless, C Doig, P McKenna, J Martin, J Murdy, A Scott, S Martin; Northampton General J Birkhead, J O'Donnell, C Fox, S Dixon, A Hassall, E Tanqueray, D Vass, I Cosford, M Elderkin, P McKenzie; Northern General T Gray, D Appleyard, N Holmshaw, A McKinnon, A Taylor-Bennett, I Ali; Northwick Park N Stephens, A Banfield, L Chester, J Wiseman, N Harrisingh, R Patel, P Thaker; Oxford Radcliffe Hospitals J Armitage, H Watkins, S Beebe, J Fitzgerald, J Godden, A Lawson, H Lochhead, A Taylor, S Turner; Peterborough D Rowlands, A Cooper, J Graham, S Hennessy, T Rashid, C Smith; Pilgrim Hospital, Boston C Nyman, J Adams, A Hardwick, P Buck, C Pattinson, J Trigg; Poole General A McLeod, S Gardner, L Haimes, S Orr, S Johns; Princess Royal, Telford N Capps, A Cook, D Donaldson, C Keighley, C Stiles, S Asbridge; Queen Elizabeth, Birmingham N Buller, J Townend, J Hooks, C Jewkes, H Jones, R Watson, P Salt; Queen Margaret, Dunfermline M Francis, D MacLeod, P Allcoat, R Stuart; Queen's Hospital, Burton-upon-Trent T Reynolds, J Maiden, J Reynolds, D Murray; Raigmore, Inverness R MacFadyen, L Potts, A Smith, L King; Rotherham General R Muthusamy, M Jones, M Lawan, J Nixon, L Wasnidge, C Weston; Royal Bolton A Hutchesson, J Evans, K Morris, M Oultram; Royal Bournemouth M Armitage, R Skule, C Cope, M Page; Royal Cornwall S Fleming, K Andain, M Parrett, R Soper; Royal Devon and Exeter K MacLeod (deceased), K Gordon, E Green, S Havill, V Stewart, S Allen, S Henson, C Rimmer; Royal Gwent J Davies, M Javed, A Norris, M Williams; Royal Preston S Khan, G Dobie, J Fitton, S Gilbert, C Davenport, M Williamson; Royal Sussex County R Vincent, E Joyce; Royal United, Bath J Reckless, A Bishop, L Brice, R Carpenter, P Field, C Shute, S Pope, D Stacey; Russell Institute, Paisley I Findlay, C Campbell, J Hunter, M Gallacher; Russells Hall M Labib, A Hodgson, J Sidaway, L Beddoe, J Reed; St Helier J Barron, O Odemuyiwa, B Bradford, M McDonnell, L West, P Beck; St James University, Leeds S Gilbey, A Clarkson, K Drury, S Hall, D Quartey, B Whittam, D Lund, L Stott; St Luke's, Huddersfield H Griffiths, D Appleyard, J Fitzgerald, A Kudarenko; St Mary's, Portsmouth J Watkins, S Golledge, J Pottle, S Little, B Paine, C Shears; St Peter's, Chertsey M Baxter, P Wilkinson, R Chambers, C Hamper, E Hollister, H Ramsay, J Barber, T Hopkins; Sandwell General L Hughes, J Elson-Whittaker, C Verow, R Lambley-Burke, C Lloyd; Scunthorpe General J Dhawan, J John, D Bramley, A Catchpole, A Colecchia, C Gray, M LeQuelenec, D Remington, J Wiseman, C Gray, P Anderson, R Woolass; Singleton, Swansea P Thomas, C Weston, F Guy, J Lynch, R Thomas, S Coates, M Gait; Southampton University Hospitals D Waller, K Elkins, M Franklin, L Moore; Southlands M Signy, R Chilton, E Joyce, C Wrapson, C Wiltshire; Stepping Hill, Stockport P Lewis, J Curtis, J O'Toole, S Scanlon; Torbay C Carey, L Dobson, M Gould, H Mansfield, G Ranson, M Rodaway, J Germon; Univ Hospital of Wales J Cockcroft, I McDowell, R Field, J Whiting, C Dennison; Victoria Hospital, Blackpool D Roberts, M Cooper, C Davies, J Fitton, L Hutt, L Radford, L Ward, M Williamson; Victoria Infirmary, Glasgow H McAlpine, H Dougall, L Robertson, L Scott, H Young; Walton Centre P Humphrey, S Saminaden, D Watling, J Davies, L Owen; Watford General M Clements, E Walker, E Atkins; Western General, Edinburgh R Lindley, T Shaw, C Swainson, D Webb, H MacCallum, D Markie, V Melville, L Adamson, A Johnston, E Polukord, M Rudden; Whipps Cross J Hogan, F Lie, V Badger, S Duffy, C Mitchell, E MacQueen; Wishaw General R Baxter, S Campbell, L McDonald, H Wood; Worcester Royal A Munro, C Pycock, J Cadwell, A Doughty, M Harvey; Wycombe General S Price, M Aldersley, S Lock, P Pendrey;
Coordinating centre (Clinical Trial Service Unit, University of Oxford):
Administration J Barton, C Bray, R Dayanandan and E Wincott (coordinators), P Achiri, C Anderson, J Benham, H Bojowsky, I Boller, V Booker, A Brewer, G Brindley, L Cobb, A Collett, M Corbett, J Crowther, S Danesh-Pour, K Edmunds, A Fortun, T Grimsey, C Harwood, C Hope, R Jones, S Jones, K Kidney, M King, S Knight, H Lang, Z Madgwick, C Marsden, C Matthews, M Matthewson, J Miller, B Moss, Y Mostefai, K Murphy, A Naughten, S Pickworth, A Radley, S Southren, S Sutherland, R Tong, M Turakani, M Umbrath; Clinical support and adjudication J Armitage, C Baigent, L Bowman, R Bulbulia, Z Chen, R Clarke, R Collins, S Dunachie, T Dasgupta, R Haynes, M Landray, M Mafham, W Majoni, C Murray, K Naessens, T Porter, K Rahimi, C Reith, M Taylor-Clarke, C Turnbull, K Walter; Computing coordinators P Harding, M Lay, K Wallendszus; Statistics and computing C Berry, H Bettesworth, J Booth, M Bowes, Y Bu, A Charles, A Cody, J Cox, J Emberson, N Goodwin, C Hurt, E Link, P McCabe, A Munday, A Murawska, A Offer, A Palmer (deceased), S Parish, R Peto, N Prajapati, S Tochlin, A Young, A Young; Laboratory S Clark, K Kourellias and M Radley (coordinators), V Ambrose, M Bradley, E Bush, T Chavagnon, B Chukwurah, S Crowley, J Dunseath, K Emmens, L Fletcher, J Gordon, A Gordon, C Hickman, J Hill, M Ji, A Lee, N Luker, S Norris, H Priestley, J Sullivan, J Taylor, J Wintour, M Yeung, L Youngman; Nurse monitors and trainers S Beebe, J Fitzgerald, J Godden, L Haimes, A Lawson, H Lochhead, M McDonnell, M Nash, A Taylor, A Taylor-Bennett, E Walton.