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Acta Crystallogr Sect E Struct Rep Online. 2010 February 1; 66(Pt 2): o440.
Published online 2010 January 23. doi:  10.1107/S1600536810001777
PMCID: PMC2979773

1-(4-Chloro­phen­yl)-4,4,6-trimethyl-3,4-dihydro­pyrimidine-2(1H)-thione

Abstract

The dihydro­pyrimidine ring of the title compound, C13H15ClN2S, adopts an envelope conformation with five almost coplanar atoms (r.m.s. deviation = 0.054 Å) and the C atom bearing the two methyl substituents deviating from this plane by 0.441 (2) Å. The best plane through the five almost coplanar atoms forms a dihedral angle of 89.56 (5)° with the benzene ring. The crystal packing is characterized by centrosymmetric dimers connected by pairs of N—H(...)S hydrogen bonds.

Related literature

For details of the biological activity of pyrimidine-2-thio­nes, see: Alam et al. (2005 [triangle]); Sriram et al. (2006 [triangle]); Leite et al. (2006 [triangle]); Kappe (2000 [triangle]); Rovnyak et al. (1995 [triangle]); Swamy et al. (2005 [triangle]). For a related structure, see: Yamin et al. (2005 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-66-0o440-scheme1.jpg

Experimental

Crystal data

  • C13H15ClN2S
  • M r = 266.78
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-66-0o440-efi1.jpg
  • a = 20.6710 (18) Å
  • b = 10.8343 (10) Å
  • c = 14.8619 (13) Å
  • β = 126.026 (5)°
  • V = 2691.9 (4) Å3
  • Z = 8
  • Mo Kα radiation
  • μ = 0.42 mm−1
  • T = 173 K
  • 0.37 × 0.29 × 0.26 mm

Data collection

  • Stoe IPDS II two-circle diffractometer
  • Absorption correction: multi-scan (MULABS; Spek, 2009 [triangle]; Blessing, 1995 [triangle]) T min = 0.861, T max = 0.899
  • 7624 measured reflections
  • 2512 independent reflections
  • 2134 reflections with I > 2σ(I)
  • R int = 0.049

Refinement

  • R[F 2 > 2σ(F 2)] = 0.035
  • wR(F 2) = 0.093
  • S = 1.02
  • 2512 reflections
  • 161 parameters
  • H atoms treated by a mixture of independent and constrained refinement
  • Δρmax = 0.22 e Å−3
  • Δρmin = −0.39 e Å−3

Data collection: X-AREA (Stoe & Cie, 2001 [triangle]); cell refinement: X-AREA; data reduction: X-AREA; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: XP (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXL97.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536810001777/zq2028sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810001777/zq2028Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

The authors gratefully acknowledge a research grant from the Higher Education Commission of Pakistan under project No. 20-Miscel/R&D/00/3834.

supplementary crystallographic information

Comment

The title compound belongs to a novel and rare class of dihydropyrimidine-2-thiones. Their synthesis has been attracting widespread attention due to diverse pharmacological activities such as antibacterial (Alam et al., 2005), antitumour (Swamy et al., 2005), antioxidative (Sriram et al., 2006), analgesic and anti-inflammatory properties (Leite et al., 2006; Kappe, 2000). In addition, these compounds act as antihypertensive agents as well as calcium channel blockers and neuropeptide Y antagonists (Rovnyak et al., 1995). The formation of the closely related 4,4,6-trimethyl-1-phenyl-3,4-dihydropyrimidine-2(1H)-thione as a side product during the reaction of cinnamoyl isothiocyanate and aniline to afford the corresponding thiourea derivative has been reported (Yamin et al., 2005) The title compound was prepared by the reaction of 4-chloroaniline with 4-methylpent-3-en-2-one in presence of potassium thiocyanate in acetone.

The dihydropyrimidine ring of the title compound adopts an envelope conformation with five almost coplanar atoms (r.m.s. deviation 0.054 Å) and the carbon atom bearing the two methyl substituents deviating from this plane by 0.441 (2) Å. The best plane through the six ring atoms forms a dihedral angle of 89.42 (5)° with the phenyl ring. The crystal packing is characterized by centrosymmetric dimers connected by N—H···S hydrogen bonds.

Experimental

Potassium thiocyanate (5.4 mmol) was added to a stirred mixture of 4-methylpent-3-en-2-one (5.4 mmol), 4-chloroaniline (5.4 mmol) in dry acetone. The reaction mixture was refluxed for 3 hours. On completion of the reaction, the reaction mixture was cooled to room temperature and poured into ice-water. The precipitated compound was recrystallized from methanol to afford the title dihydropyrimidine-2-thione (62%). Recrystallization from methanol afforded the title compound as colourless crystals: Anal. calcd. for C13H15N2S: C, 58.53; H, 5.67; N, 10.50; S, 12.02%; found: C, 58.49; H, 5.72; N, 10.61; S, 12.14%;%.

Refinement

Hydrogen atoms were located in a difference Fourier map but they were all included in calculated positions [Caromatic—H = 0.95 Å; Cmethyl—H = 0.98°] and refined as riding [Uiso(H) = 1.2Ueq(C) or Uiso(H) = 1.5Ueq(Cmethyl)]. The methyl groups were allowed to rotate but not to tip.

Figures

Fig. 1.
Molecular structure of the title compound. Displacement ellipsoids are drawn at the 50% probability level.

Crystal data

C13H15ClN2SF(000) = 1120
Mr = 266.78Dx = 1.317 Mg m3
Monoclinic, C2/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -C 2ycCell parameters from 6686 reflections
a = 20.6710 (18) Åθ = 3.4–26.1°
b = 10.8343 (10) ŵ = 0.42 mm1
c = 14.8619 (13) ÅT = 173 K
β = 126.026 (5)°Block, colourless
V = 2691.9 (4) Å30.37 × 0.29 × 0.26 mm
Z = 8

Data collection

Stoe IPDS II two-circle diffractometer2512 independent reflections
Radiation source: fine-focus sealed tube2134 reflections with I > 2σ(I)
graphiteRint = 0.049
ω scansθmax = 25.7°, θmin = 3.4°
Absorption correction: multi-scan (MULABS; Spek, 2009; Blessing, 1995)h = −25→24
Tmin = 0.861, Tmax = 0.899k = −13→13
7624 measured reflectionsl = −16→18

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.035Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.093H atoms treated by a mixture of independent and constrained refinement
S = 1.02w = 1/[σ2(Fo2) + (0.0634P)2] where P = (Fo2 + 2Fc2)/3
2512 reflections(Δ/σ)max = 0.001
161 parametersΔρmax = 0.22 e Å3
0 restraintsΔρmin = −0.39 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
S10.57142 (2)0.69991 (4)0.42770 (3)0.02504 (14)
Cl10.68751 (3)0.59306 (4)0.93548 (3)0.03636 (15)
N10.47205 (7)0.78438 (12)0.47357 (11)0.0219 (3)
H10.4318 (11)0.7666 (19)0.2421 (18)0.027 (5)*
C20.48383 (9)0.75825 (14)0.39373 (13)0.0202 (3)
N30.42364 (8)0.78513 (13)0.28874 (12)0.0239 (3)
C40.33943 (9)0.80299 (15)0.24811 (13)0.0240 (4)
C50.34219 (9)0.86623 (15)0.34036 (14)0.0251 (3)
H50.29830.91650.32210.030*
C60.40392 (9)0.85420 (15)0.44661 (14)0.0238 (3)
C70.29744 (11)0.67811 (18)0.21978 (17)0.0364 (4)
H7A0.30150.63560.16510.055*
H7B0.24100.69070.18860.055*
H7C0.32290.62800.28740.055*
C80.29878 (10)0.88397 (18)0.14363 (15)0.0348 (4)
H9A0.32730.96270.16210.052*
H9B0.24320.89930.11570.052*
H9C0.29990.84160.08630.052*
C90.40992 (11)0.91451 (18)0.54228 (15)0.0342 (4)
H8A0.36070.96080.51430.051*
H8B0.45570.97100.58040.051*
H8C0.41730.85110.59460.051*
C110.52708 (9)0.73685 (15)0.58519 (12)0.0209 (3)
C120.51342 (9)0.62101 (15)0.60981 (13)0.0236 (3)
H120.46980.57270.55310.028*
C130.56377 (9)0.57500 (15)0.71809 (14)0.0251 (3)
H130.55500.49550.73590.030*
C140.62664 (9)0.64743 (15)0.79878 (13)0.0237 (3)
C150.64175 (9)0.76243 (16)0.77479 (14)0.0271 (4)
H150.68590.80990.83130.033*
C160.59136 (10)0.80791 (15)0.66666 (14)0.0260 (4)
H160.60090.88690.64880.031*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
S10.0186 (2)0.0362 (3)0.0192 (2)0.00399 (14)0.01047 (17)0.00264 (15)
Cl10.0372 (2)0.0389 (3)0.0182 (2)0.00307 (17)0.00804 (19)0.00696 (16)
N10.0217 (6)0.0262 (7)0.0175 (7)0.0037 (5)0.0114 (6)0.0023 (5)
C20.0220 (7)0.0197 (7)0.0190 (7)−0.0011 (6)0.0120 (6)0.0013 (6)
N30.0193 (6)0.0360 (8)0.0162 (7)0.0046 (5)0.0104 (6)0.0030 (5)
C40.0182 (7)0.0276 (8)0.0213 (8)0.0039 (6)0.0089 (7)0.0023 (6)
C50.0230 (7)0.0254 (8)0.0273 (8)0.0045 (6)0.0151 (7)0.0027 (6)
C60.0252 (7)0.0233 (8)0.0264 (8)0.0024 (6)0.0172 (7)0.0022 (6)
C70.0299 (9)0.0330 (9)0.0442 (11)−0.0031 (7)0.0206 (9)−0.0078 (8)
C80.0298 (9)0.0410 (10)0.0232 (9)0.0098 (7)0.0097 (8)0.0067 (8)
C90.0365 (9)0.0395 (10)0.0301 (9)0.0075 (7)0.0216 (8)−0.0014 (8)
C110.0222 (7)0.0256 (8)0.0157 (7)0.0024 (6)0.0116 (6)0.0015 (6)
C120.0222 (7)0.0234 (8)0.0223 (8)−0.0024 (6)0.0114 (7)−0.0016 (6)
C130.0270 (8)0.0230 (8)0.0246 (8)0.0004 (6)0.0148 (7)0.0034 (6)
C140.0244 (7)0.0286 (8)0.0153 (7)0.0039 (6)0.0101 (6)0.0024 (6)
C150.0259 (8)0.0291 (8)0.0198 (8)−0.0044 (6)0.0097 (7)−0.0026 (7)
C160.0294 (8)0.0248 (8)0.0226 (8)−0.0040 (6)0.0146 (7)0.0006 (6)

Geometric parameters (Å, °)

S1—C21.6904 (15)C8—H9A0.9800
Cl1—C141.7465 (16)C8—H9B0.9800
N1—C21.374 (2)C8—H9C0.9800
N1—C61.4327 (19)C9—H8A0.9800
N1—C111.4462 (19)C9—H8B0.9800
C2—N31.336 (2)C9—H8C0.9800
N3—C41.482 (2)C11—C121.382 (2)
N3—H10.83 (2)C11—C161.390 (2)
C4—C51.504 (2)C12—C131.397 (2)
C4—C71.527 (2)C12—H120.9500
C4—C81.534 (2)C13—C141.382 (2)
C5—C61.330 (2)C13—H130.9500
C5—H50.9500C14—C151.381 (2)
C6—C91.502 (2)C15—C161.393 (2)
C7—H7A0.9800C15—H150.9500
C7—H7B0.9800C16—H160.9500
C7—H7C0.9800
C2—N1—C6120.78 (13)H9A—C8—H9B109.5
C2—N1—C11119.87 (12)C4—C8—H9C109.5
C6—N1—C11119.30 (13)H9A—C8—H9C109.5
N3—C2—N1116.59 (13)H9B—C8—H9C109.5
N3—C2—S1121.92 (13)C6—C9—H8A109.5
N1—C2—S1121.46 (11)C6—C9—H8B109.5
C2—N3—C4124.65 (15)H8A—C9—H8B109.5
C2—N3—H1114.6 (14)C6—C9—H8C109.5
C4—N3—H1117.4 (13)H8A—C9—H8C109.5
N3—C4—C5106.41 (13)H8B—C9—H8C109.5
N3—C4—C7109.73 (13)C12—C11—C16120.79 (14)
C5—C4—C7111.46 (15)C12—C11—N1118.79 (13)
N3—C4—C8107.47 (14)C16—C11—N1120.40 (14)
C5—C4—C8111.52 (14)C11—C12—C13119.95 (14)
C7—C4—C8110.09 (14)C11—C12—H12120.0
C6—C5—C4122.23 (14)C13—C12—H12120.0
C6—C5—H5118.9C14—C13—C12118.71 (15)
C4—C5—H5118.9C14—C13—H13120.6
C5—C6—N1118.87 (15)C12—C13—H13120.6
C5—C6—C9124.65 (15)C15—C14—C13121.88 (14)
N1—C6—C9116.40 (13)C15—C14—Cl1119.14 (12)
C4—C7—H7A109.5C13—C14—Cl1118.97 (13)
C4—C7—H7B109.5C14—C15—C16119.19 (14)
H7A—C7—H7B109.5C14—C15—H15120.4
C4—C7—H7C109.5C16—C15—H15120.4
H7A—C7—H7C109.5C11—C16—C15119.47 (15)
H7B—C7—H7C109.5C11—C16—H16120.3
C4—C8—H9A109.5C15—C16—H16120.3
C4—C8—H9B109.5
C6—N1—C2—N3−9.4 (2)C2—N1—C6—C9−159.70 (15)
C11—N1—C2—N3168.04 (14)C11—N1—C6—C922.8 (2)
C6—N1—C2—S1168.43 (11)C2—N1—C11—C12−87.68 (19)
C11—N1—C2—S1−14.1 (2)C6—N1—C11—C1289.81 (18)
N1—C2—N3—C4−19.9 (2)C2—N1—C11—C1693.85 (19)
S1—C2—N3—C4162.28 (12)C6—N1—C11—C16−88.66 (19)
C2—N3—C4—C536.3 (2)C16—C11—C12—C131.1 (2)
C2—N3—C4—C7−84.4 (2)N1—C11—C12—C13−177.39 (14)
C2—N3—C4—C8155.86 (16)C11—C12—C13—C140.1 (2)
N3—C4—C5—C6−26.8 (2)C12—C13—C14—C15−1.2 (3)
C7—C4—C5—C692.80 (19)C12—C13—C14—Cl1177.54 (13)
C8—C4—C5—C6−143.71 (17)C13—C14—C15—C161.2 (3)
C4—C5—C6—N13.6 (2)Cl1—C14—C15—C16−177.54 (13)
C4—C5—C6—C9−179.71 (16)C12—C11—C16—C15−1.1 (3)
C2—N1—C6—C517.2 (2)N1—C11—C16—C15177.36 (15)
C11—N1—C6—C5−160.24 (15)C14—C15—C16—C11−0.1 (3)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
N3—H1···S1i0.83 (2)2.59 (2)3.4054 (16)169.1 (17)

Symmetry codes: (i) −x+1, y, −z+1/2.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: ZQ2028).

References

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  • Swamy, S. N., Basappa, Priya, B. S., Prabhuswamy, B., Doreswamy, B. H., Prasad, J. S. & Rangappa K. S. (2005). Eur. J. Med. Chem.41, 531–538. [PubMed]
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