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Acta Crystallogr Sect E Struct Rep Online. 2010 February 1; 66(Pt 2): o325.
Published online 2010 January 9. doi:  10.1107/S160053680905555X
PMCID: PMC2979731

N-(2,6-Dimethyl­phen­yl)succinimide

Abstract

The mol­ecule of the title compound, C12H13NO2, lies on a twofold rotation axis that passes through the N and Cpara atoms as well as through the mid-point of the bond between the methyl­ene C atoms. The dihedral angle between the aromatic ring and the amide segment is 75.9 (1)°.

Related literature

For our studies on the effect of ring and side-chain substitutions on the structures of this class of compounds, see: Gowda et al. (2007 [triangle], 2009a [triangle],b [triangle]).

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Object name is e-66-0o325-scheme1.jpg

Experimental

Crystal data

  • C12H13NO2
  • M r = 203.23
  • Tetragonal, An external file that holds a picture, illustration, etc.
Object name is e-66-0o325-efi1.jpg
  • a = 9.4048 (3) Å
  • c = 23.685 (1) Å
  • V = 2094.94 (13) Å3
  • Z = 8
  • Mo Kα radiation
  • μ = 0.09 mm−1
  • T = 299 K
  • 0.44 × 0.44 × 0.40 mm

Data collection

  • Oxford Diffraction Xcalibur diffractometer
  • Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009 [triangle])’ T min = 0.962, T max = 0.966
  • 7329 measured reflections
  • 1062 independent reflections
  • 942 reflections with I > 2σ(I)
  • R int = 0.024

Refinement

  • R[F 2 > 2σ(F 2)] = 0.058
  • wR(F 2) = 0.150
  • S = 1.11
  • 1062 reflections
  • 70 parameters
  • H-atom parameters constrained
  • Δρmax = 0.21 e Å−3
  • Δρmin = −0.45 e Å−3

Data collection: CrysAlis CCD (Oxford Diffraction, 2009 [triangle]); cell refinement: CrysAlis CCD; data reduction: CrysAlis RED (Oxford Diffraction, 2009 [triangle]); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: PLATON (Spek, 2009 [triangle]); software used to prepare material for publication: SHELXL97.

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S160053680905555X/ng2713sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S160053680905555X/ng2713Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

BSS thanks the University Grants Commission, Government of India, New Delhi, for the award of a research fellowship under its faculty improvement program.

supplementary crystallographic information

Comment

The amide moiety is an important constituent of many biologically significant compounds. As a part of studying the effect of ring and side chain substitutions on the structures of this class of compounds (Gowda et al., 2007; 2009a,b), the crystal structure of N,N-(2,6-dimethylphenyl)succinimide has been determined (I) (Fig. 1).

The structure shows crystallographic inversion symmetry: there is one half-molecule in the asymmetric unit. The dihedral angle between the part of benzene ring and part of the amide segment in the two halves of the molecule is 75.9 (1)°.

The torsional angles of the groups, C2$1 - C1 - N1 - C5, C2 - C1 - N1 - C5, C2$1 - C1 - N1 - C5$1 and C2 - C1 - N1 - C5$1 in the molecule are -73.9 (1)°, 106.1 (1)°, 106.1 (1)° and -73.9 (1)°, respectively.

The packing of molecules into column like infinite chains parrallel to the a-axis is shown in Fig.2.

Experimental

The solution of succinic anhydride (0.025 mole) in toluene (25 ml) was treated dropwise with the solution of 2,6-dimethylaniline (0.025 mole) also in toluene (20 ml) with constant stirring. The resulting mixture was stirred for one hour and set aside for an additional hour at room temperature for the completion of reaction. The mixture was then treated with dilute hydrochloric acid to remove the unreacted 2,6-dimethylaniline. The resultant solid N-(2,6-dimethylphenyl)succinamic acid was filtered under suction and washed thoroughly with water to remove the unreacted succinic anhydride and succinic acid. It was recrystallized to constant melting point from ethanol. N-(2,6-Dimethylphenyl)succinamic acid was then heated for 2 h and then allowed to cool slowly to room temperature to get crystals of N-(2,6-dimethylphenyl)succinimide. The purity of the compound was checked by elemental analysis and characterized by its infrared spectra. The prism like colourless single crystals of the compound used in X-ray diffraction studies were grown in ethanolic solution by slow evaporation at room temperature.

Refinement

The H atoms were positioned with idealized geometry using a riding model with C—H = 0.93–0.97 Å. Isotropic displacement parameters for the H atoms were set equal to 1.2 Ueq (parent atom).

Figures

Fig. 1.
Molecular structure of the title compound, showing the atom labelling scheme. The displacement ellipsoids are drawn at the 50% probability level. The H atoms are represented as small spheres of arbitrary radii.
Fig. 2.
Molecular packing of the title compound.

Crystal data

C12H13NO2Dx = 1.289 Mg m3
Mr = 203.23Mo Kα radiation, λ = 0.71073 Å
Tetragonal, I41/aCell parameters from 5744 reflections
Hall symbol: -I 4adθ = 2.8–27.9°
a = 9.4048 (3) ŵ = 0.09 mm1
c = 23.685 (1) ÅT = 299 K
V = 2094.94 (13) Å3Prism, colourless
Z = 80.44 × 0.44 × 0.40 mm
F(000) = 864

Data collection

Oxford Diffraction Xcalibur diffractometer1062 independent reflections
Radiation source: fine-focus sealed tube942 reflections with I > 2σ(I)
graphiteRint = 0.024
Rotation method data acquisition using ω and [var phi] scans.θmax = 26.4°, θmin = 3.4°
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2009)'h = −11→11
Tmin = 0.962, Tmax = 0.966k = −11→11
7329 measured reflectionsl = −28→26

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.058Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.150H-atom parameters constrained
S = 1.11w = 1/[σ2(Fo2) + (0.0961P)2 + 0.6791P] where P = (Fo2 + 2Fc2)/3
1062 reflections(Δ/σ)max < 0.001
70 parametersΔρmax = 0.21 e Å3
0 restraintsΔρmin = −0.45 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
C10.50000.25000.10156 (7)0.0325 (4)
C20.38264 (14)0.30632 (13)0.13004 (6)0.0376 (4)
C30.38515 (18)0.30545 (16)0.18861 (6)0.0499 (4)
H30.30860.34260.20860.060*
C40.50000.25000.21748 (9)0.0570 (6)
H40.50000.25000.25670.068*
C50.58183 (14)0.34178 (15)0.00845 (6)0.0401 (4)
C60.56001 (18)0.30343 (18)−0.05269 (6)0.0504 (4)
H6A0.64570.2621−0.06850.060*
H6B0.53460.3868−0.07460.060*
C70.25630 (16)0.36549 (17)0.09927 (6)0.0495 (4)
H7A0.19180.28970.09020.059*
H7B0.28730.41080.06510.059*
H7C0.20900.43380.12280.059*
N10.50000.25000.04113 (6)0.0335 (4)
O10.65642 (13)0.43332 (13)0.02778 (5)0.0606 (4)

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
C10.0383 (9)0.0299 (8)0.0292 (9)−0.0041 (6)0.0000.000
C20.0424 (7)0.0318 (7)0.0384 (8)−0.0004 (5)0.0050 (5)0.0021 (5)
C30.0661 (10)0.0451 (8)0.0384 (8)0.0064 (7)0.0143 (7)−0.0008 (6)
C40.0886 (17)0.0525 (12)0.0299 (10)0.0066 (11)0.0000.000
C50.0418 (7)0.0430 (7)0.0355 (7)−0.0079 (5)0.0002 (5)0.0049 (5)
C60.0596 (9)0.0590 (9)0.0324 (8)−0.0113 (7)0.0035 (6)0.0031 (6)
C70.0411 (8)0.0509 (8)0.0564 (9)0.0065 (6)0.0056 (6)0.0070 (7)
N10.0345 (8)0.0372 (8)0.0290 (8)−0.0047 (6)0.0000.000
O10.0700 (8)0.0646 (8)0.0470 (7)−0.0348 (6)−0.0061 (5)0.0056 (5)

Geometric parameters (Å, °)

C1—C2i1.3978 (15)C5—N11.3916 (15)
C1—C21.3978 (15)C5—C61.5064 (19)
C1—N11.431 (2)C6—C6i1.511 (3)
C2—C31.387 (2)C6—H6A0.9700
C2—C71.5008 (19)C6—H6B0.9700
C3—C41.3807 (19)C7—H7A0.9600
C3—H30.9300C7—H7B0.9600
C4—C3i1.3807 (19)C7—H7C0.9600
C4—H40.9300N1—C5i1.3916 (15)
C5—O11.2012 (17)
C2i—C1—C2122.29 (17)C5—C6—C6i105.13 (8)
C2i—C1—N1118.85 (8)C5—C6—H6A110.7
C2—C1—N1118.85 (8)C6i—C6—H6A110.7
C3—C2—C1117.83 (13)C5—C6—H6B110.7
C3—C2—C7120.07 (12)C6i—C6—H6B110.7
C1—C2—C7122.10 (13)H6A—C6—H6B108.8
C4—C3—C2120.71 (14)C2—C7—H7A109.5
C4—C3—H3119.6C2—C7—H7B109.5
C2—C3—H3119.6H7A—C7—H7B109.5
C3—C4—C3i120.63 (19)C2—C7—H7C109.5
C3—C4—H4119.7H7A—C7—H7C109.5
C3i—C4—H4119.7H7B—C7—H7C109.5
O1—C5—N1123.75 (13)C5—N1—C5i112.40 (15)
O1—C5—C6128.14 (13)C5—N1—C1123.80 (8)
N1—C5—C6108.11 (12)C5i—N1—C1123.80 (8)
C2i—C1—C2—C30.13 (9)O1—C5—N1—C5i177.17 (18)
N1—C1—C2—C3−179.87 (9)C6—C5—N1—C5i−3.48 (8)
C2i—C1—C2—C7−179.44 (14)O1—C5—N1—C1−2.83 (18)
N1—C1—C2—C70.56 (14)C6—C5—N1—C1176.52 (8)
C1—C2—C3—C4−0.27 (19)C2i—C1—N1—C5−73.92 (9)
C7—C2—C3—C4179.31 (11)C2—C1—N1—C5106.08 (9)
C2—C3—C4—C3i0.14 (10)C2i—C1—N1—C5i106.08 (9)
O1—C5—C6—C6i−171.85 (18)C2—C1—N1—C5i−73.92 (9)
N1—C5—C6—C6i8.8 (2)

Symmetry codes: (i) −x+1, −y+1/2, z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: NG2713).

References

  • Gowda, B. T., Foro, S., Saraswathi, B. S. & Fuess, H. (2009a). Acta Cryst. E65, o2056. [PMC free article] [PubMed]
  • Gowda, B. T., Foro, S., Saraswathi, B. S., Terao, H. & Fuess, H. (2009b). Acta Cryst. E65, o399. [PMC free article] [PubMed]
  • Gowda, B. T., Kozisek, J., Svoboda, I. & Fuess, H. (2007). Z. Naturforsch. Teil A, 62, 91–100.
  • Oxford Diffraction (2009). CrysAlis CCD and CrysAlis RED Oxford Diffraction Ltd, Yarnton, England.
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Spek, A. L. (2009). Acta Cryst. D65, 148–155. [PMC free article] [PubMed]

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