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Acta Crystallogr Sect E Struct Rep Online. 2010 May 1; 66(Pt 5): o1158.
Published online 2010 April 24. doi:  10.1107/S1600536810014406
PMCID: PMC2979225

(Z)-N-(3-Nicotinoyl-1,3-thia­zolidin-2-yl­idene)cyanamide

Abstract

In the title compound, C10H8N4OS, the dihedral angle between the pyridine and thia­zolidine rings is 52.5 (5)°. Inter­molecular C—H(...)N inter­actions help to stabilize the crystal structure.

Related literature

For related structures, see: Wang et al. (2008 [triangle]); Liu & Li (2009 [triangle]). For the biological activity of thia­zolidine-containing compounds, see: Iwata et al. (1988 [triangle]); Ogawa (2000 [triangle]). For bond-length data, see: Allen et al. (1987 [triangle]).

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Object name is e-66-o1158-scheme1.jpg

Experimental

Crystal data

  • C10H8N4OS
  • M r = 232.26
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-66-o1158-efi1.jpg
  • a = 5.9180 (12) Å
  • b = 15.182 (3) Å
  • c = 11.448 (2) Å
  • β = 94.62 (3)°
  • V = 1025.2 (4) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.30 mm−1
  • T = 173 K
  • 0.17 × 0.07 × 0.05 mm

Data collection

  • Rigaku Mercury CCD/AFC diffractometer
  • Absorption correction: multi-scan (CrystalClear; Rigaku, 2007 [triangle]) T min = 0.951, T max = 0.985
  • 7491 measured reflections
  • 1799 independent reflections
  • 1699 reflections with I > 2σ(I)
  • R int = 0.054

Refinement

  • R[F 2 > 2σ(F 2)] = 0.043
  • wR(F 2) = 0.095
  • S = 1.15
  • 1799 reflections
  • 145 parameters
  • H-atom parameters constrained
  • Δρmax = 0.28 e Å−3
  • Δρmin = −0.19 e Å−3

Data collection: CrystalClear (Rigaku, 2007 [triangle]); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: SHELXTL (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXTL.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810014406/hg2674sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810014406/hg2674Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Comment

Thiazolidine is an important group in organic chemistry. Many compounds containing thiazolidine groups possess a broad spectrum of biological activities (Iwata et al., 1988; Ogawa, 2000). In order to search for new thiazolidine compounds with higher bioactivity, we synthesized the title compound and describe its structure here.

In title compound, all bond lengths in the molecular are normal (Allen et al., 1987) and in a good agreement with those reported previously (Wang et al., 2008; Liu & Li, 2009). The dihedral angle between pyridine (C1—C5/N1) and thiazolidine (C7—C9/N2/S1) rings is 52.5 (5)°. The intermolecular C—H···N hydrogen bonds stabilize the structure.

Experimental

A mixture of N-cyanoiminothiazolidine 10 mmol (1.27 g), nicotinoyl chloride (1.42 g, 10 mmol) and (1.01 g, 10 mmol ) triethylamine is refluxed in absolute acetone (25 ml) for 4 h. On cooling, the product crystallizes and is filtered, and recrystallized from absolute EtOH, yield 2.13 g (92%). Single crystals suitable for X-ray measurements were obtained by recrystallization from dichloromethane at room temperature.

Refinement

H atoms were positioned geometrically and refined using a riding model, with C—H = 0.93 or 0.97 Å and with Uiso(H) = 1.2 times Ueq(C).

Figures

Fig. 1.
The molecular structure of (I), with atom labels and 40% probability displacement ellipsoids for non-H atoms.

Crystal data

C10H8N4OSF(000) = 480
Mr = 232.26Dx = 1.505 Mg m3
Monoclinic, P21/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybcCell parameters from 3351 reflections
a = 5.9180 (12) Åθ = 1.3–27.5°
b = 15.182 (3) ŵ = 0.30 mm1
c = 11.448 (2) ÅT = 173 K
β = 94.62 (3)°Needle, colorless
V = 1025.2 (4) Å30.17 × 0.07 × 0.05 mm
Z = 4

Data collection

Rigaku Mercury CCD/AFC diffractometer1799 independent reflections
Radiation source: Sealed Tube1699 reflections with I > 2σ(I)
Graphite MonochromatorRint = 0.054
[var phi] and ω scansθmax = 25.0°, θmin = 2.2°
Absorption correction: multi-scan (CrystalClear; Rigaku, 2007)h = −6→7
Tmin = 0.951, Tmax = 0.985k = −18→18
7491 measured reflectionsl = −13→13

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.043Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.095H-atom parameters constrained
S = 1.15w = 1/[σ2(Fo2) + (0.0269P)2 + 0.7053P] where P = (Fo2 + 2Fc2)/3
1799 reflections(Δ/σ)max = 0.001
145 parametersΔρmax = 0.28 e Å3
0 restraintsΔρmin = −0.19 e Å3

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
S10.07382 (9)0.71271 (4)0.18314 (5)0.02782 (18)
O10.6823 (2)0.58746 (10)−0.01165 (14)0.0305 (4)
N10.0795 (3)0.54439 (13)−0.29129 (17)0.0316 (5)
N20.3613 (3)0.63953 (12)0.05512 (15)0.0230 (4)
N30.0875 (3)0.72532 (12)−0.05117 (15)0.0253 (4)
N4−0.2685 (4)0.81222 (15)−0.06511 (18)0.0426 (6)
C10.5188 (4)0.60983 (14)−0.2489 (2)0.0264 (5)
H1A0.66630.6306−0.23470.032*
C20.4329 (4)0.58936 (16)−0.3616 (2)0.0318 (5)
H2A0.52020.5972−0.42480.038*
C30.2154 (4)0.55716 (16)−0.3780 (2)0.0338 (6)
H3B0.15910.5434−0.45400.041*
C40.1635 (4)0.56544 (14)−0.1829 (2)0.0262 (5)
H4A0.07200.5573−0.12140.031*
C50.3806 (3)0.59877 (13)−0.15738 (19)0.0217 (5)
C60.4871 (4)0.60973 (13)−0.03604 (19)0.0228 (5)
C70.4663 (4)0.63253 (15)0.17646 (18)0.0254 (5)
H7A0.56990.68110.19400.030*
H7B0.54960.57770.18710.030*
C80.2732 (4)0.63538 (15)0.25500 (19)0.0268 (5)
H8A0.32520.65570.33290.032*
H8B0.20480.57770.26110.032*
C90.1716 (3)0.69261 (14)0.04735 (19)0.0222 (5)
C10−0.1045 (4)0.77156 (15)−0.05189 (18)0.0280 (5)

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
S10.0233 (3)0.0389 (4)0.0215 (3)0.0052 (2)0.0034 (2)−0.0013 (2)
O10.0204 (9)0.0388 (9)0.0324 (9)0.0057 (7)0.0024 (6)0.0012 (7)
N10.0276 (11)0.0311 (11)0.0363 (12)−0.0026 (8)0.0029 (9)−0.0036 (9)
N20.0185 (9)0.0278 (10)0.0228 (10)0.0038 (7)0.0023 (7)0.0007 (8)
N30.0237 (10)0.0293 (10)0.0232 (10)0.0055 (8)0.0044 (7)0.0029 (8)
N40.0399 (13)0.0566 (14)0.0306 (12)0.0207 (12)−0.0015 (9)−0.0012 (10)
C10.0205 (11)0.0250 (11)0.0342 (13)−0.0001 (9)0.0058 (9)−0.0007 (10)
C20.0334 (14)0.0362 (13)0.0272 (13)0.0006 (11)0.0104 (10)−0.0007 (10)
C30.0368 (14)0.0371 (14)0.0272 (13)−0.0029 (11)0.0006 (10)−0.0058 (10)
C40.0252 (12)0.0246 (11)0.0300 (12)0.0030 (9)0.0088 (9)0.0000 (9)
C50.0192 (11)0.0197 (10)0.0267 (11)0.0029 (8)0.0037 (8)0.0000 (9)
C60.0202 (12)0.0202 (11)0.0286 (12)−0.0009 (9)0.0057 (9)0.0007 (9)
C70.0232 (12)0.0272 (11)0.0252 (12)0.0028 (9)−0.0014 (9)−0.0013 (9)
C80.0259 (12)0.0303 (12)0.0237 (12)−0.0016 (10)−0.0014 (9)0.0030 (9)
C90.0176 (11)0.0222 (10)0.0270 (12)−0.0015 (9)0.0034 (9)−0.0004 (9)
C100.0311 (13)0.0344 (12)0.0187 (11)0.0057 (11)0.0037 (9)−0.0003 (9)

Geometric parameters (Å, °)

S1—C91.729 (2)C1—H1A0.9300
S1—C81.814 (2)C2—C31.376 (3)
O1—C61.214 (3)C2—H2A0.9300
N1—C41.338 (3)C3—H3B0.9300
N1—C31.342 (3)C4—C51.390 (3)
N2—C91.379 (3)C4—H4A0.9300
N2—C61.405 (3)C5—C61.488 (3)
N2—C71.479 (3)C7—C81.510 (3)
N3—C91.295 (3)C7—H7A0.9700
N3—C101.335 (3)C7—H7B0.9700
N4—C101.150 (3)C8—H8A0.9700
C1—C21.383 (3)C8—H8B0.9700
C1—C51.391 (3)
C9—S1—C892.34 (10)C1—C5—C6117.34 (19)
C4—N1—C3116.86 (19)O1—C6—N2118.05 (19)
C9—N2—C6128.16 (18)O1—C6—C5120.49 (19)
C9—N2—C7112.40 (17)N2—C6—C5121.28 (18)
C6—N2—C7117.80 (17)N2—C7—C8106.01 (17)
C9—N3—C10118.32 (18)N2—C7—H7A110.5
C2—C1—C5118.8 (2)C8—C7—H7A110.5
C2—C1—H1A120.6N2—C7—H7B110.5
C5—C1—H1A120.6C8—C7—H7B110.5
C3—C2—C1118.5 (2)H7A—C7—H7B108.7
C3—C2—H2A120.8C7—C8—S1104.14 (14)
C1—C2—H2A120.8C7—C8—H8A110.9
N1—C3—C2124.1 (2)S1—C8—H8A110.9
N1—C3—H3B118.0C7—C8—H8B110.9
C2—C3—H3B118.0S1—C8—H8B110.9
N1—C4—C5123.4 (2)H8A—C8—H8B108.9
N1—C4—H4A118.3N3—C9—N2122.30 (19)
C5—C4—H4A118.3N3—C9—S1125.63 (17)
C4—C5—C1118.4 (2)N2—C9—S1112.01 (15)
C4—C5—C6123.50 (19)N4—C10—N3172.7 (2)
C5—C1—C2—C3−1.3 (3)C1—C5—C6—N2150.65 (19)
C4—N1—C3—C20.6 (4)C9—N2—C7—C834.3 (2)
C1—C2—C3—N10.2 (4)C6—N2—C7—C8−159.14 (18)
C3—N1—C4—C5−0.3 (3)N2—C7—C8—S1−36.57 (19)
N1—C4—C5—C1−0.8 (3)C9—S1—C8—C725.54 (16)
N1—C4—C5—C6−170.6 (2)C10—N3—C9—N2175.9 (2)
C2—C1—C5—C41.6 (3)C10—N3—C9—S1−7.2 (3)
C2—C1—C5—C6172.0 (2)C6—N2—C9—N3−2.5 (3)
C9—N2—C6—O1157.6 (2)C7—N2—C9—N3162.4 (2)
C7—N2—C6—O1−6.6 (3)C6—N2—C9—S1−179.73 (17)
C9—N2—C6—C5−27.3 (3)C7—N2—C9—S1−14.8 (2)
C7—N2—C6—C5168.55 (18)C8—S1—C9—N3175.7 (2)
C4—C5—C6—O1135.5 (2)C8—S1—C9—N2−7.10 (17)
C1—C5—C6—O1−34.3 (3)C9—N3—C10—N4−178 (2)
C4—C5—C6—N2−39.5 (3)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
C2—H2A···N4i0.932.523.383 (3)154
C8—H8B···N1ii0.972.553.481 (3)162

Symmetry codes: (i) x+1, −y+3/2, z−1/2; (ii) −x, −y+1, −z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: HG2674).

References

  • Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G. & Taylor, R. (1987). J. Chem. Soc. Perkin Trans. 2, pp. S1–19.
  • Iwata, C., Watanabe, M., Okamoto, S., Fujimoto, M., Sakae, M., Katsurada, M. & Imanishi, T. (1988). Synthesis, pp. 261–262.
  • Liu, X.-L. & Li, Y.-M. (2009). Acta Cryst. E65, o1645. [PMC free article] [PubMed]
  • Ogawa, T. (2000). Jpn Patent JP 2000226378.
  • Rigaku (2007). CrystalClear Rigaku Corporation, Tokyo, Japan.
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Wang, J.-G., Huang, L.-H. & Jian, F.-F. (2008). Acta Cryst. E64, o2321. [PMC free article] [PubMed]

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