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Acta Crystallogr Sect E Struct Rep Online. 2010 May 1; 66(Pt 5): o1242.
Published online 2010 April 30. doi:  10.1107/S1600536810015540
PMCID: PMC2979188

Ethyl 2-(6-amino-5-cyano-3,4-dimethyl-2H,4H-pyrano[2,3-c]pyrazol-4-yl)acetate

Abstract

In he title compound, C13H16N4O3, the pyrazole ring is planar (r.m.s. deviation = 0.054 Å). The pyran ring is not planar; the mean plane makes a dihedral angle of 1.9 (1)° with the pyrazole ring. In the crystal structure, inter­molecular N—H(...)N and N—H(...)O inter­actions lead to a linear chain motif.

Related literature

For biological applications of pyrazole and pyran­opyrazole derivatives, see: Wamhoff et al. (1993 [triangle]).; Velaparthi et al. (2008 [triangle]); Magedov et al. (2007 [triangle]); Rovnyak et al. (1982 [triangle]). For the synthesis, see: Vasuki & Kumaravel (2008 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-66-o1242-scheme1.jpg

Experimental

Crystal data

  • C13H16N4O3
  • M r = 276.30
  • Triclinic, An external file that holds a picture, illustration, etc.
Object name is e-66-o1242-efi1.jpg
  • a = 6.961 (5) Å
  • b = 7.373 (5) Å
  • c = 14.535 (5) Å
  • α = 86.405 (5)°
  • β = 85.183 (5)°
  • γ = 65.726 (5)°
  • V = 677.3 (7) Å3
  • Z = 2
  • Mo Kα radiation
  • μ = 0.10 mm−1
  • T = 293 K
  • 0.25 × 0.20 × 0.20 mm

Data collection

  • Bruker Kappa APEXII CCD diffractometer
  • Absorption correction: multi-scan (SADABS; Bruker 2004 [triangle]) T min = 0.976, T max = 0.981
  • 12811 measured reflections
  • 2385 independent reflections
  • 2130 reflections with I > 2σ(I)
  • R int = 0.020

Refinement

  • R[F 2 > 2σ(F 2)] = 0.041
  • wR(F 2) = 0.117
  • S = 1.02
  • 2378 reflections
  • 184 parameters
  • H-atom parameters constrained
  • Δρmax = 0.30 e Å−3
  • Δρmin = −0.26 e Å−3

Data collection: APEX2 (Bruker, 2004 [triangle]); cell refinement: APEX2 and SAINT (Bruker, 2004 [triangle]); data reduction: SAINT and XPREP (Bruker, 2004 [triangle]); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 [triangle]); software used to prepare material for publication: PLATON (Spek, 2009 [triangle]).

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810015540/ng2761sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810015540/ng2761Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

The authors acknowledge the Centre of Excellence in Bioinformatics, Pondicherry University, for providing the facilities and GV thanks the Department of Science and Technology, New Delhi, Government of India, (No. SR/S5/GC-22/2007) for financial support.

supplementary crystallographic information

Comment

Pyrazole, Pyranopyrazoles and its derivates possess antimicrobial (Velaparthi et al.,2008),anticancer (Magedov et al.,2007) and anti-inflammatory (Rovnyak et al.,1982) properties,which made them to be used as a medicines and as biodegradable agrochemiclas (Wamhoff et al., 1993).Wide variety of biological importances of these molecules made the quest for their crystal study and accordingly we have synthesized the title compound by multi-component reaction which compiles with the principles of green chemistry and reported the crystal structure of the title compound.

The compound was crystallized by slow evaporation technique using ethanol as solvent at room temperature. The title compound, (I) was centrosymmetric and it has triclinic crystal system with the space group of P-1. The pyrazole groups are essentially planar, with a mean deviation of 0.0542 Å from the least square plane defined by the five atoms (N1 to C1). The pyran ring deviates significantly from the plane and it has dihedral angle of 1.93 (0.06)° with pyrazole ring. The ethyl acetate group has dihedral angle of 49.99 (0.07)° with pyran ring to which it is attached (Fig. 1). The intermolecular hydrogen bond was formed between N2···N1, N3···N4, N2—H···O2 and N3—H···O3 with distance of 2.956 (2), 3.012 (2), 3.274 (2) and 3.192 (2) Å respectively (Table.1). These intermolecular interactions help in theformation three-dimensional network and crystal packing (Fig. 2) of (I).

Experimental

The titled compound was prepared bythe successive addition of malononitrile (0.132 g, 2 mmol) and piperidine (5 mol%) to a stirred aqueous mixture of hydrazine hydrate 96% 1 (0.107 g, 2 mmol)and ethyl acetoacetate 2 (0.520 g, 4 mmol) at room temperature under an openatmosphere with vigorous stirring for 5–10 min. The precipitated solid wasfiltered, washed with water and then with a mixture of ethyl acetate/hexane(20:80) (Vasuki & Kumaravel, 2008). The product obtained was pure by TLCand 1H NMR spectroscopy. However, the products were further purifiedby recrystallization from ethanol. Analysis calculated for ethyl2-(6-amino-5-cyano-3,4-dimethyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl) acetate showed that it has C13, H16,N4, O3.

Refinement

The non-hydrogen atoms where refined anisotropically whereas hydrogen atoms were refined isotropically. The H atoms were geometrically placed (N—H = 0.86 Å, and C—H=0.93-0.97 Å) and refined as riding with Uiso(H) = 1.2-1.5 Ueq (parent atom).

Figures

Fig. 1.
: The molecular structure of (I), showing the atom-numbering scheme and displacement ellipsoids drawn at the 30% probability level.
Fig. 2.
: The crystal packing of (I), showing intermolecular hydrogen bonding interactions as dashed lines.

Crystal data

C13H16N4O3Z = 2
Mr = 276.30F(000) = 292
Triclinic, P1Dx = 1.355 Mg m3
Hall symbol: -P 1Mo Kα radiation, λ = 0.71069 Å
a = 6.961 (5) ÅCell parameters from 7682 reflections
b = 7.373 (5) Åθ = 2.8–32.8°
c = 14.535 (5) ŵ = 0.10 mm1
α = 86.405 (5)°T = 293 K
β = 85.183 (5)°Block, colourless
γ = 65.726 (5)°0.25 × 0.20 × 0.20 mm
V = 677.3 (7) Å3

Data collection

Bruker Kappa APEXII CCD diffractometer2385 independent reflections
Radiation source: fine-focus sealed tube2130 reflections with I > 2σ(I)
graphiteRint = 0.020
Detector resolution: 0 pixels mm-1θmax = 25.0°, θmin = 2.8°
ω and [var phi] scanh = −8→8
Absorption correction: multi-scan (SADABS; Bruker 2004)k = −8→8
Tmin = 0.976, Tmax = 0.981l = −17→17
12811 measured reflections

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.041Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.117H-atom parameters constrained
S = 1.02w = 1/[σ2(Fo2) + (0.0655P)2 + 0.2561P] where P = (Fo2 + 2Fc2)/3
2378 reflections(Δ/σ)max = 0.001
184 parametersΔρmax = 0.30 e Å3
0 restraintsΔρmin = −0.26 e Å3

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.Some "bad" relections were omitted in the refinement.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
C10.4375 (2)0.8266 (2)0.84125 (10)0.0288 (3)
C20.3125 (2)0.7231 (2)0.86328 (9)0.0271 (3)
C30.2551 (2)0.6151 (2)0.79351 (9)0.0271 (3)
C40.3682 (2)0.6404 (2)0.70213 (9)0.0282 (3)
C50.4908 (2)0.7439 (2)0.68793 (10)0.0306 (3)
C60.0126 (2)0.7009 (2)0.78369 (10)0.0329 (3)
H6A−0.01640.62760.73750.040*
H6B−0.05630.68180.84200.040*
C7−0.0780 (2)0.9167 (2)0.75667 (11)0.0378 (4)
C8−0.1525 (3)1.1488 (3)0.62848 (17)0.0654 (6)
H8A−0.25281.24020.67240.078*
H8B−0.22171.16360.57150.078*
C90.0317 (5)1.1990 (4)0.6104 (3)0.1088 (12)
H9A0.08871.20230.66790.163*
H9B−0.01091.32710.57940.163*
H9C0.13751.10030.57220.163*
C100.2672 (2)0.7477 (2)0.95731 (10)0.0320 (3)
C110.1408 (3)0.6754 (3)1.02539 (11)0.0487 (5)
H11A0.21770.53561.03800.073*
H11B0.00910.69781.00060.073*
H11C0.11400.74611.08160.073*
C120.3282 (3)0.3931 (2)0.82003 (11)0.0385 (4)
H12A0.47800.33510.82610.058*
H12B0.29510.32700.77290.058*
H12C0.25740.37820.87770.058*
C130.3419 (2)0.5481 (2)0.62484 (10)0.0354 (4)
N10.4738 (2)0.9108 (2)0.91081 (8)0.0351 (3)
N20.3649 (2)0.8596 (2)0.98199 (8)0.0357 (3)
H20.35890.89541.03770.043*
N30.5923 (2)0.7662 (2)0.60839 (9)0.0474 (4)
H3A0.58310.71140.55940.057*
H3B0.66670.83520.60640.057*
N40.3189 (3)0.4715 (3)0.56322 (10)0.0555 (4)
O10.52556 (17)0.84545 (17)0.75515 (7)0.0367 (3)
O2−0.1338 (2)1.0482 (2)0.81014 (10)0.0659 (4)
O3−0.08990 (18)0.94621 (17)0.66504 (8)0.0450 (3)

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
C10.0306 (7)0.0354 (7)0.0243 (7)−0.0169 (6)−0.0013 (5)−0.0047 (6)
C20.0271 (7)0.0322 (7)0.0246 (7)−0.0142 (6)−0.0018 (5)−0.0038 (5)
C30.0277 (7)0.0322 (7)0.0250 (7)−0.0153 (6)−0.0012 (5)−0.0050 (5)
C40.0269 (7)0.0353 (7)0.0253 (7)−0.0148 (6)−0.0007 (5)−0.0071 (6)
C50.0307 (7)0.0399 (8)0.0245 (7)−0.0172 (6)−0.0006 (6)−0.0069 (6)
C60.0291 (7)0.0450 (8)0.0312 (8)−0.0213 (6)0.0005 (6)−0.0068 (6)
C70.0250 (7)0.0454 (9)0.0434 (9)−0.0128 (6)−0.0036 (6)−0.0124 (7)
C80.0592 (12)0.0478 (11)0.0810 (15)−0.0144 (9)−0.0116 (11)0.0124 (10)
C90.096 (2)0.0740 (17)0.171 (3)−0.0526 (16)−0.029 (2)0.0415 (19)
C100.0376 (8)0.0365 (8)0.0267 (7)−0.0196 (6)−0.0016 (6)−0.0048 (6)
C110.0692 (12)0.0637 (11)0.0298 (8)−0.0450 (10)0.0083 (8)−0.0090 (8)
C120.0481 (9)0.0344 (8)0.0364 (8)−0.0197 (7)−0.0038 (7)−0.0028 (6)
C130.0362 (8)0.0488 (9)0.0289 (8)−0.0255 (7)0.0042 (6)−0.0088 (7)
N10.0430 (7)0.0457 (7)0.0273 (6)−0.0284 (6)−0.0011 (5)−0.0067 (5)
N20.0487 (8)0.0459 (7)0.0224 (6)−0.0286 (6)−0.0015 (5)−0.0069 (5)
N30.0591 (9)0.0738 (10)0.0300 (7)−0.0484 (8)0.0114 (6)−0.0162 (7)
N40.0675 (10)0.0859 (12)0.0357 (8)−0.0534 (9)0.0097 (7)−0.0243 (8)
O10.0446 (6)0.0537 (7)0.0266 (6)−0.0350 (5)0.0047 (4)−0.0106 (5)
O20.0652 (9)0.0518 (8)0.0677 (9)−0.0048 (7)−0.0160 (7)−0.0270 (7)
O30.0440 (7)0.0432 (6)0.0457 (7)−0.0163 (5)−0.0008 (5)−0.0005 (5)

Geometric parameters (Å, °)

C1—N11.3125 (19)C8—H8A0.9700
C1—O11.3714 (18)C8—H8B0.9700
C1—C21.383 (2)C9—H9A0.9600
C2—C101.383 (2)C9—H9B0.9600
C2—C31.5006 (19)C9—H9C0.9600
C3—C41.527 (2)C10—N21.346 (2)
C3—C121.535 (2)C10—C111.487 (2)
C3—C61.556 (2)C11—H11A0.9600
C4—C51.356 (2)C11—H11B0.9600
C4—C131.411 (2)C11—H11C0.9600
C5—N31.341 (2)C12—H12A0.9600
C5—O11.3616 (17)C12—H12B0.9600
C6—C71.490 (2)C12—H12C0.9600
C6—H6A0.9700C13—N41.144 (2)
C6—H6B0.9700N1—N21.3572 (18)
C7—O21.195 (2)N2—H20.8600
C7—O31.340 (2)N3—H3A0.8600
C8—O31.452 (2)N3—H3B0.8600
C8—C91.474 (4)
N1—C1—O1118.81 (13)H8A—C8—H8B108.0
N1—C1—C2115.28 (13)C8—C9—H9A109.5
O1—C1—C2125.90 (13)C8—C9—H9B109.5
C1—C2—C10103.21 (13)H9A—C9—H9B109.5
C1—C2—C3123.21 (13)C8—C9—H9C109.5
C10—C2—C3133.58 (13)H9A—C9—H9C109.5
C2—C3—C4105.90 (12)H9B—C9—H9C109.5
C2—C3—C12111.39 (12)N2—C10—C2106.01 (13)
C4—C3—C12109.91 (12)N2—C10—C11122.04 (14)
C2—C3—C6112.12 (11)C2—C10—C11131.95 (14)
C4—C3—C6110.22 (12)C10—C11—H11A109.5
C12—C3—C6107.33 (12)C10—C11—H11B109.5
C5—C4—C13116.78 (13)H11A—C11—H11B109.5
C5—C4—C3126.29 (13)C10—C11—H11C109.5
C13—C4—C3116.93 (13)H11A—C11—H11C109.5
N3—C5—C4126.98 (14)H11B—C11—H11C109.5
N3—C5—O1109.58 (13)C3—C12—H12A109.5
C4—C5—O1123.44 (13)C3—C12—H12B109.5
C7—C6—C3112.62 (12)H12A—C12—H12B109.5
C7—C6—H6A109.1C3—C12—H12C109.5
C3—C6—H6A109.1H12A—C12—H12C109.5
C7—C6—H6B109.1H12B—C12—H12C109.5
C3—C6—H6B109.1N4—C13—C4178.79 (17)
H6A—C6—H6B107.8C1—N1—N2101.70 (12)
O2—C7—O3123.82 (17)C10—N2—N1113.80 (12)
O2—C7—C6124.23 (16)C10—N2—H2123.1
O3—C7—C6111.94 (13)N1—N2—H2123.1
O3—C8—C9111.08 (18)C5—N3—H3A120.0
O3—C8—H8A109.4C5—N3—H3B120.0
C9—C8—H8A109.4H3A—N3—H3B120.0
O3—C8—H8B109.4C5—O1—C1115.14 (12)
C9—C8—H8B109.4C7—O3—C8117.56 (15)
N1—C1—C2—C100.13 (17)C12—C3—C6—C7−179.24 (12)
O1—C1—C2—C10179.38 (13)C3—C6—C7—O2−85.9 (2)
N1—C1—C2—C3−179.36 (12)C3—C6—C7—O394.18 (15)
O1—C1—C2—C3−0.1 (2)C1—C2—C10—N20.13 (16)
C1—C2—C3—C42.14 (18)C3—C2—C10—N2179.54 (14)
C10—C2—C3—C4−177.17 (15)C1—C2—C10—C11−179.84 (17)
C1—C2—C3—C12121.60 (15)C3—C2—C10—C11−0.4 (3)
C10—C2—C3—C12−57.7 (2)C5—C4—C13—N4169 (9)
C1—C2—C3—C6−118.10 (15)C3—C4—C13—N4−11 (9)
C10—C2—C3—C662.6 (2)O1—C1—N1—N2−179.63 (12)
C2—C3—C4—C5−1.37 (19)C2—C1—N1—N2−0.32 (17)
C12—C3—C4—C5−121.80 (16)C2—C10—N2—N1−0.35 (17)
C6—C3—C4—C5120.10 (16)C11—C10—N2—N1179.63 (15)
C2—C3—C4—C13178.97 (12)C1—N1—N2—C100.41 (17)
C12—C3—C4—C1358.54 (17)N3—C5—O1—C1−177.10 (12)
C6—C3—C4—C13−59.56 (17)C4—C5—O1—C13.8 (2)
C13—C4—C5—N3−0.9 (2)N1—C1—O1—C5176.23 (12)
C3—C4—C5—N3179.41 (14)C2—C1—O1—C5−3.0 (2)
C13—C4—C5—O1178.03 (13)O2—C7—O3—C87.0 (2)
C3—C4—C5—O1−1.6 (2)C6—C7—O3—C8−173.07 (14)
C2—C3—C6—C758.13 (16)C9—C8—O3—C787.2 (3)
C4—C3—C6—C7−59.57 (16)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
N2—H2···O2i0.862.553.274 (2)142
N2—H2···N1ii0.862.372.956 (2)126
N3—H3A···N4iii0.862.193.012 (2)160
N3—H3B···O3iv0.862.403.192 (2)154

Symmetry codes: (i) −x, −y+2, −z+2; (ii) −x+1, −y+2, −z+2; (iii) −x+1, −y+1, −z+1; (iv) x+1, y, z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: NG2761).

References

  • Bruker (2004). APEX2, SAINT and XPREP Bruker AXS Inc., Madison, Wisconsin, USA.
  • Farrugia, L. J. (1997). J. Appl. Cryst.30, 565.
  • Magedov, I. V., Manpadi, M., Vanslambrouck, S., Steelant, W. F. A., Rozhkova, E., Przhevalskii, N. M., Rogelj, S. & Kornienko, A. (2007). J. Med. Chem.50, 5183–5192. [PubMed]
  • Rovnyak, G. C., Millonig, R. C., Schwartz, J. & Shu, V. (1982). J. Med. Chem.25, 1482–1488. [PubMed]
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Spek, A. L. (2009). Acta Cryst. D65, 148–155. [PMC free article] [PubMed]
  • Vasuki, G. & Kumaravel, K. (2008). Tetrahedron Lett.49, 5636–5638.
  • Velaparthi, S., Brunsteiner, M., Uddin, R., Wan, B., Franzblau, S. G. & Petukhov, P. A. (2008). J. Med. Chem.51, 1999–2002. [PubMed]
  • Wamhoff, H., Kroth, E. & Strauch, K. (1993). Synthesis, 11, 1129.

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