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Logo of brcnresBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleBreast Cancer Research : BCR
Breast Cancer Res. 2010; 12(Suppl 3): P19.
Published online 2010 October 25. doi:  10.1186/bcr2672
PMCID: PMC2978836

Effect of region of interest size in quantitative diffusion-weighted magnetic resonance imaging of the breast


In breast MRI, morphological and dynamic enhancement features determine whether a lesion is benign or malignant but specificity is low. Diffusion-weighted magnetic resonance imaging (DW-MRI) measures microscopic motion of water and gives quantitative measurement known as the apparent diffusion coefficient (ADC). This study was conducted to determine whether the whole of the lesion should be included within the region of interest (ROI) or whether a small ROI would differentiate benign from malignant disease.


Fifteen female patients with 15 suspicious lesions were imaged on a 3T MRI machine (Philips HealthCare, Best, the Netherlands). DWI-MRI was performed with b-values of 0, 150, 800 s/mm2 using single-shot SE-EPI (TR/ TE = 9,543 ms/50 ms). The ROI of the lesion and of fibroglandular tissue was used to calculate ADC values. Histology or follow-up data were available for all lesions.


The mean ADC value of malignant lesions (13) from two small ROIs was 0.954 ± 0.145 mm2/second and for benign (2) was 1.69 ± 0.17 mm2/ second (Figure (Figure1a).1a). The ADC values for the whole lesion were 1.027 ± 0.23 mm2/second and 1.78 ± 0.293 mm2/second, respectively (Figure (Figure1b1b).

Figure 1
Box plot of ADC values for benign, malignant and normal tissue using (a) two small ROIs and (b) a large ROI.


There is a significant difference between ADC values from large and small ROIs (P <0.05), with small ROIs giving greater differentiation. DWI is a promising technique to improve specificity of breast MRI.

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