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|Cover: Structure of human Trifunctional Purine Biosynthetic Protein Adenosine-3, a component of the purinosome complex. A putative model deduced from x-ray solution scattering and based on rigid body fitting of crystal structures of the enzymatic domains is portrayed as a transparent surface. Enzymatic units and linker segments are shown in unique colours. The enzyme catalyses steps 2,3 and 5 of the purine biosynthetic pathway starting with phosphoribosylamine (PRA) and ending with aminoimidazole ribonucleotide (AIR) depicted in the reaction scheme and as ball-an-stick models. Flexibility and conformation of the full-length protein would allow straightforward transfer of intermediates to the downstream enzyme. The “seesaw” shape also suggests that it can act as a central scaffolding component of the purinosome complex. The image was created with MarwinSketch, Pymol and Gimp.|
|For further information, please see the article by Welin et al., Nucleic Acids Res., 2010, 38, 7308–7319.|