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Acta Crystallogr Sect E Struct Rep Online. 2009 November 1; 65(Pt 11): o2806.
Published online 2009 October 23. doi:  10.1107/S1600536809042329
PMCID: PMC2971203

1-(3-Phenyl­prop-2-yn­yl)pyrrolidinium chloride

Abstract

The title compound C13H16N+·Cl, an achiral salt, was synthesized by a three-component coupling reaction in the presence of copper(I) iodide. The configuration of five-membered ring is close to an envelope conformation. The crystal structure is stabilized by inter­molecular C—H(...)Cl and N—H(...)Cl inter­actions.

Related literature

For the preparation of the title compound, see: Nilsson et al. (1992 [triangle]). For background to propargylamines, see: Dyker (1999 [triangle]); Hattori et al. (1993 [triangle]); Konishi et al. (1990 [triangle]).

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Object name is e-65-o2806-scheme1.jpg

Experimental

Crystal data

  • C13H16N+·Cl
  • M r = 221.72
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-65-o2806-efi1.jpg
  • a = 10.9504 (2) Å
  • b = 11.3553 (3) Å
  • c = 11.1951 (2) Å
  • β = 117.008 (1)°
  • V = 1240.24 (4) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.28 mm−1
  • T = 298 K
  • 0.20 × 0.10 × 0.10 mm

Data collection

  • Bruker SMART CCD area-detector diffractometer
  • Absorption correction: none
  • 10560 measured reflections
  • 2432 independent reflections
  • 2353 reflections with I > 2σ(I)
  • R int = 0.054

Refinement

  • R[F 2 > 2σ(F 2)] = 0.067
  • wR(F 2) = 0.158
  • S = 1.27
  • 2432 reflections
  • 139 parameters
  • 1 restraint
  • H atoms treated by a mixture of independent and constrained refinement
  • Δρmax = 0.35 e Å−3
  • Δρmin = −0.21 e Å−3

Data collection: SMART (Bruker, 2001 [triangle]); cell refinement: SAINT (Bruker, 2001 [triangle]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: SHELXTL (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXTL.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809042329/pb2009sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809042329/pb2009Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

The author is grateful to Central China Normal University for support.

supplementary crystallographic information

Comment

Propargylamines, which have interesting biological activities, are compounds of versatile and important synthetic intermediates. (Konishi et al., 1990; Hattori et al., 1993; Dyker et al.,1999). The reaction which a three component procedure between terminal alkynes, formaldehyde and secondary amines and give rise to the propargylamines with rapid reaction rates by the introduction of copper (I) catalysts.

Here we report the crystal structure of the title compound (Fig. 1). The length of the N1—C9 bond in this compound was found to be 1.479 Å, which is approximate with the length of ordinary N—C single bond (1.47 Å).The four carbon atoms of the five–member ring are not in the same plane, the torsion angle is 14.92 °. It was close to the envelope conformation.

X-ray analysis reveals that the crystal structure is stabilized by C—H···Cl interaction and N—H···Cl interaction.

Experimental

The title compound was synthesized according to the literature procedure of Nilsson et al. (1992).

Single crystals suitable for X–ray diffraction were prepared by slow evaporation of a solution of the title compound in chloroform : methanol (20 : 1) and adding 1d HCl at room temperature.

Refinement

All H atoms were initially located in a difference map, but were constrained to an idealized geometry. Constrained bond lengths and isotropic displacement parameters: (C—H = 0.97 Å) and Uiso(H) =1.2 Ueq(C) for methylene, and (C—H = 0.93 Å) and Uiso(H) =1.2Ueq(C) for aromatic H atoms.

Figures

Fig. 1.
View of the molecule of (I) showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 30% probability level. H atoms are represented by spheres of arbitrary radius.

Crystal data

C13H16N+·ClF(000) = 472
Mr = 221.72Dx = 1.187 Mg m3
Monoclinic, P21/cMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybcCell parameters from 5548 reflections
a = 10.9504 (2) Åθ = 2.7–28.1°
b = 11.3553 (3) ŵ = 0.28 mm1
c = 11.1951 (2) ÅT = 298 K
β = 117.008 (1)°Block, colorless
V = 1240.24 (4) Å30.20 × 0.10 × 0.10 mm
Z = 4

Data collection

Bruker SMART CCD area-detector diffractometer2353 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.054
graphiteθmax = 26.0°, θmin = 2.1°
[var phi] and ω scansh = −13→13
10560 measured reflectionsk = −14→14
2432 independent reflectionsl = −13→13

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.067Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.158H atoms treated by a mixture of independent and constrained refinement
S = 1.27w = 1/[σ2(Fo2) + (0.053P)2 + 0.6238P] where P = (Fo2 + 2Fc2)/3
2432 reflections(Δ/σ)max < 0.001
139 parametersΔρmax = 0.35 e Å3
1 restraintΔρmin = −0.21 e Å3

Special details

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2sigma(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
C10.6296 (3)0.8606 (2)0.7343 (3)0.0493 (6)
C20.4916 (3)0.8723 (3)0.6473 (3)0.0620 (7)
H20.46360.92430.57550.074*
C30.3957 (3)0.8078 (3)0.6660 (4)0.0735 (9)
H30.30320.81620.60690.088*
C40.4359 (4)0.7315 (3)0.7707 (4)0.0774 (10)
H40.37080.68780.78310.093*
C50.5724 (4)0.7188 (3)0.8581 (4)0.0734 (9)
H50.59910.66630.92940.088*
C60.6697 (3)0.7830 (2)0.8413 (3)0.0590 (7)
H60.76200.77460.90130.071*
C70.7303 (3)0.9288 (2)0.7156 (3)0.0551 (7)
C80.8158 (3)0.9840 (2)0.7040 (3)0.0570 (7)
C90.9214 (3)1.0575 (2)0.6955 (3)0.0581 (7)
H9A0.92761.13160.74100.070*
H9B0.89521.07480.60210.070*
C101.1669 (3)1.0766 (3)0.7524 (3)0.0666 (8)
H10A1.16791.06990.66650.080*
H10B1.15131.15840.76660.080*
C111.2991 (3)1.0342 (3)0.8625 (3)0.0759 (9)
H11A1.35031.09940.91900.091*
H11B1.35450.99710.82580.091*
C121.2620 (4)0.9460 (3)0.9424 (3)0.0784 (9)
H12A1.27900.86620.92270.094*
H12B1.31530.96011.03780.094*
C131.1110 (3)0.9647 (3)0.8992 (3)0.0640 (8)
H13A1.06790.89280.90810.077*
H13B1.09671.02650.95130.077*
Cl10.03151 (7)0.70879 (6)0.07738 (7)0.0545 (2)
N11.0572 (2)0.99964 (19)0.7561 (2)0.0491 (5)
H11.051 (3)0.9386 (17)0.707 (2)0.059*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
C10.0479 (14)0.0489 (14)0.0587 (15)−0.0012 (11)0.0308 (12)−0.0117 (12)
C20.0534 (16)0.0660 (17)0.0676 (18)0.0029 (13)0.0284 (14)0.0021 (14)
C30.0471 (16)0.082 (2)0.090 (2)−0.0070 (15)0.0306 (16)−0.0131 (18)
C40.079 (2)0.075 (2)0.103 (3)−0.0238 (18)0.063 (2)−0.019 (2)
C50.095 (3)0.0597 (18)0.078 (2)−0.0041 (16)0.051 (2)0.0032 (15)
C60.0556 (16)0.0596 (17)0.0616 (17)0.0044 (13)0.0265 (14)−0.0063 (13)
C70.0528 (15)0.0557 (15)0.0642 (17)−0.0009 (12)0.0329 (14)−0.0069 (12)
C80.0559 (16)0.0579 (16)0.0628 (17)−0.0023 (13)0.0317 (14)−0.0067 (13)
C90.0617 (17)0.0524 (15)0.0664 (18)−0.0038 (13)0.0345 (15)−0.0002 (13)
C100.0595 (17)0.0709 (19)0.0699 (19)−0.0164 (14)0.0297 (15)0.0096 (15)
C110.0622 (19)0.095 (2)0.070 (2)−0.0112 (17)0.0293 (17)−0.0061 (18)
C120.080 (2)0.085 (2)0.0586 (18)0.0083 (18)0.0219 (17)0.0059 (16)
C130.081 (2)0.0623 (17)0.0562 (17)−0.0052 (15)0.0383 (16)0.0044 (13)
Cl10.0537 (4)0.0555 (4)0.0528 (4)0.0018 (3)0.0228 (3)0.0045 (3)
N10.0566 (13)0.0470 (12)0.0498 (12)−0.0099 (10)0.0296 (11)−0.0019 (9)

Geometric parameters (Å, °)

C1—C21.383 (4)C9—H9B0.9700
C1—C61.388 (4)C10—C111.492 (5)
C1—C71.439 (4)C10—N11.501 (3)
C2—C31.372 (4)C10—H10A0.9700
C2—H20.9300C10—H10B0.9700
C3—C41.360 (5)C11—C121.516 (5)
C3—H30.9300C11—H11A0.9700
C4—C51.372 (5)C11—H11B0.9700
C4—H40.9300C12—C131.512 (5)
C5—C61.373 (4)C12—H12A0.9700
C5—H50.9300C12—H12B0.9700
C6—H60.9300C13—N11.488 (3)
C7—C81.182 (4)C13—H13A0.9700
C8—C91.465 (4)C13—H13B0.9700
C9—N11.479 (4)N1—H10.868 (10)
C9—H9A0.9700
C2—C1—C6119.1 (3)N1—C10—H10A110.5
C2—C1—C7120.7 (3)C11—C10—H10B110.5
C6—C1—C7120.3 (3)N1—C10—H10B110.5
C3—C2—C1120.6 (3)H10A—C10—H10B108.7
C3—C2—H2119.7C10—C11—C12106.3 (3)
C1—C2—H2119.7C10—C11—H11A110.5
C4—C3—C2120.1 (3)C12—C11—H11A110.5
C4—C3—H3120.0C10—C11—H11B110.5
C2—C3—H3120.0C12—C11—H11B110.5
C3—C4—C5120.2 (3)H11A—C11—H11B108.7
C3—C4—H4119.9C13—C12—C11105.4 (3)
C5—C4—H4119.9C13—C12—H12A110.7
C4—C5—C6120.6 (3)C11—C12—H12A110.7
C4—C5—H5119.7C13—C12—H12B110.7
C6—C5—H5119.7C11—C12—H12B110.7
C5—C6—C1119.6 (3)H12A—C12—H12B108.8
C5—C6—H6120.2N1—C13—C12102.8 (2)
C1—C6—H6120.2N1—C13—H13A111.2
C8—C7—C1178.0 (3)C12—C13—H13A111.2
C7—C8—C9176.5 (3)N1—C13—H13B111.2
C8—C9—N1112.1 (2)C12—C13—H13B111.2
C8—C9—H9A109.2H13A—C13—H13B109.1
N1—C9—H9A109.2C9—N1—C13115.9 (2)
C8—C9—H9B109.2C9—N1—C10112.3 (2)
N1—C9—H9B109.2C13—N1—C10104.7 (2)
H9A—C9—H9B107.9C9—N1—H1107 (2)
C11—C10—N1106.1 (2)C13—N1—H1110 (2)
C11—C10—H10A110.5C10—N1—H1106.3 (19)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
C6—H6···Cl1i0.932.813.726 (3)170
C9—H9A···Cl1ii0.972.613.547 (3)164
N1—H1···Cl1iii0.87 (1)2.16 (1)3.028 (2)178 (3)

Symmetry codes: (i) x+1, y, z+1; (ii) −x+1, −y+2, −z+1; (iii) x+1, −y+3/2, z+1/2.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: PB2009).

References

  • Bruker (2001). SMART and SAINT . Bruker AXS Inc., Madison, Wisconsin, USA.
  • Dyker, G. (1999). Angew. Chem Int. Ed.38, 1698–1712.
  • Hattori, K., Miyata, M. & Yamamoto, H. (1993). J. Am. Chem. Soc.115, 1151–1152.
  • Konishi, M., Ohkuma, H., Tsuno, T., Oki, T., VanDuyne, G. D. & Clardy, J. (1990). J. Am. Chem. Soc.112, 3715–3716.
  • Nilsson, B. M., Vargas, H. M., Ringdahl, B. & Hacksell, U. (1992). J. Med. Chem.35, 285–294. [PubMed]
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]

Articles from Acta Crystallographica Section E: Structure Reports Online are provided here courtesy of International Union of Crystallography