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Acta Crystallogr Sect E Struct Rep Online. 2009 October 1; 65(Pt 10): o2587.
Published online 2009 September 30. doi:  10.1107/S1600536809038811
PMCID: PMC2970368

5-(2-Fluoro­benzyl­idene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Abstract

The title compound, C13H11FO4, was prepared by the reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione and 2-fluoro­benzaldehyde in ethanol. In the crystal structure, mol­ecules are linked into chains by weak inter­molecular C—H(...)O hydrogen bonds.

Related literature

For background to the use of Meldrum’s acid as a reagent in organic synthesis, see: Kuhn et al. (2003 [triangle]); Casadesus et al. (2006 [triangle]).

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Object name is e-65-o2587-scheme1.jpg

Experimental

Crystal data

  • C13H11FO4
  • M r = 250.22
  • Triclinic, An external file that holds a picture, illustration, etc.
Object name is e-65-o2587-efi1.jpg
  • a = 5.9907 (12) Å
  • b = 7.6135 (15) Å
  • c = 13.712 (3) Å
  • α = 104.66 (3)°
  • β = 97.00 (3)°
  • γ = 98.50 (3)°
  • V = 590.0 (2) Å3
  • Z = 2
  • Mo Kα radiation
  • μ = 0.12 mm−1
  • T = 293 K
  • 0.18 × 0.15 × 0.10 mm

Data collection

  • Bruker SMART CCD diffractometer
  • Absorption correction: none
  • 5846 measured reflections
  • 2680 independent reflections
  • 2232 reflections with I > 2σ(I)
  • R int = 0.015

Refinement

  • R[F 2 > 2σ(F 2)] = 0.040
  • wR(F 2) = 0.122
  • S = 1.09
  • 2680 reflections
  • 163 parameters
  • H-atom parameters constrained
  • Δρmax = 0.29 e Å−3
  • Δρmin = −0.21 e Å−3

Data collection: SMART (Bruker, 1997 [triangle]); cell refinement: SAINT (Bruker, 1997 [triangle]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: SHELXTL (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXTL.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536809038811/lh2910sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809038811/lh2910Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Comment

Starting with its discovery and correct structural assignment, Meldrum's acid has become a widely used reagent in organic synthesis (Kuhn et al., 2003; Casadesus et al., 2006) owing to the interesting conformational features of the products. We report here the synthesis and structure of the title compound,(I) (Fig. 1). The crystal structure analysis confirms the structure of the title compound with atom C7 connected to the 1,3-dioxane ring via a C4-C7 single bond [1.464 (2)Å] and the phenyl ring via a C7═C9 double bond [1.334 (2)Å]. The crystal structure is stabilized by weak intermolecular C—H···O hydrogen bonds (Table 1).

Experimental

The mixture of malonic acid (6.24 g, 0.06 mol) and acetic anhydride(9 ml) in strong sulfuric acid (0.25 ml) was stirred with water at 303K, After dissolving, propan-2-one (3.48 g, 0.06 mol) was added dropwise into solution for 1 h. The reaction was allowed to proceed for 2 h. The mixture was cooled and filtered, and then an ethanol solution of 2-fluorobenzaldehyde (7.67g,0.06 mol) was added. The solution was then filtered and concentrated. Single crystals were obtained by evaporation of an petroleum ether-ethylacetate (2:1 v/v) solution of (I) at room temperature over a period of one week.

Refinement

The H atoms were placed in calculated positions (C—H = 0.93–0.96 Å), and refined as riding with Uiso(H) = 1.2Ueq(C) or 1.5Ueq(methyl C).

Figures

Fig. 1.
The molecular structure of (I), drawn with 30% probability ellipsoids and spheres of arbritrary size for the H atoms.

Crystal data

C13H11FO4Z = 2
Mr = 250.22F(000) = 260
Triclinic, P1Dx = 1.408 Mg m3
Hall symbol: -P 1Mo Kα radiation, λ = 0.71073 Å
a = 5.9907 (12) ÅCell parameters from 2680 reflections
b = 7.6135 (15) Åθ = 3.1–27.5°
c = 13.712 (3) ŵ = 0.12 mm1
α = 104.66 (3)°T = 293 K
β = 97.00 (3)°Block, colorless
γ = 98.50 (3)°0.18 × 0.15 × 0.10 mm
V = 590.0 (2) Å3

Data collection

Bruker SMART CCD diffractometer2232 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.015
graphiteθmax = 27.5°, θmin = 3.1°
[var phi] and ω scansh = −7→7
5846 measured reflectionsk = −9→9
2680 independent reflectionsl = −17→17

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.040Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.122H-atom parameters constrained
S = 1.09w = 1/[σ2(Fo2) + (0.0689P)2 + 0.0762P] where P = (Fo2 + 2Fc2)/3
2680 reflections(Δ/σ)max < 0.001
163 parametersΔρmax = 0.28 e Å3
0 restraintsΔρmin = −0.21 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
O40.24998 (15)0.52398 (12)0.08949 (6)0.0433 (2)
F−0.21328 (14)0.74829 (12)0.22191 (7)0.0610 (3)
O30.42130 (16)0.39182 (13)0.21066 (7)0.0487 (2)
O20.19470 (18)0.81052 (13)0.13437 (7)0.0532 (3)
C100.22839 (19)0.67636 (17)0.16038 (9)0.0387 (3)
O10.5140 (2)0.54637 (16)0.37345 (8)0.0694 (4)
C40.0848 (2)0.93620 (17)0.35028 (9)0.0418 (3)
C110.2576 (2)0.35465 (17)0.11792 (9)0.0413 (3)
C70.2194 (2)0.78997 (18)0.34775 (9)0.0436 (3)
H7A0.27800.77900.41150.052*
C90.2713 (2)0.66953 (16)0.26804 (9)0.0390 (3)
C6−0.2546 (2)1.0510 (2)0.29876 (11)0.0521 (3)
H6A−0.39671.03060.25780.063*
C5−0.1258 (2)0.91420 (18)0.29004 (9)0.0430 (3)
C80.4099 (2)0.53311 (18)0.29079 (10)0.0455 (3)
C30.1648 (3)1.1072 (2)0.42261 (11)0.0547 (4)
H3A0.30341.12610.46600.066*
C130.3522 (3)0.2316 (2)0.03544 (11)0.0592 (4)
H13A0.50070.29230.03010.089*
H13B0.25160.2058−0.02860.089*
H13C0.36490.11790.05200.089*
C20.0417 (3)1.2483 (2)0.43080 (12)0.0613 (4)
H2A0.10041.36270.47750.074*
C1−0.1683 (3)1.2195 (2)0.36964 (12)0.0582 (4)
H1A−0.25221.31410.37620.070*
C120.0242 (3)0.2714 (2)0.13214 (12)0.0566 (4)
H12A−0.02660.35640.18560.085*
H12B0.03170.15830.15030.085*
H12C−0.08150.24620.06960.085*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
O40.0517 (5)0.0425 (5)0.0385 (4)0.0132 (4)0.0100 (4)0.0124 (4)
F0.0480 (5)0.0557 (5)0.0669 (5)0.0051 (4)−0.0003 (4)0.0021 (4)
O30.0514 (5)0.0451 (5)0.0475 (5)0.0221 (4)−0.0027 (4)0.0065 (4)
O20.0690 (6)0.0492 (5)0.0510 (5)0.0235 (5)0.0113 (4)0.0233 (4)
C100.0364 (5)0.0409 (6)0.0410 (6)0.0114 (5)0.0064 (5)0.0129 (5)
O10.0878 (8)0.0677 (7)0.0492 (6)0.0420 (6)−0.0159 (5)0.0068 (5)
C40.0452 (6)0.0436 (7)0.0389 (6)0.0171 (5)0.0077 (5)0.0103 (5)
C110.0442 (6)0.0387 (6)0.0402 (6)0.0099 (5)0.0034 (5)0.0098 (5)
C70.0463 (6)0.0461 (7)0.0387 (6)0.0170 (5)0.0013 (5)0.0100 (5)
C90.0390 (6)0.0393 (6)0.0394 (6)0.0128 (5)0.0017 (5)0.0114 (5)
C60.0409 (6)0.0620 (9)0.0593 (8)0.0191 (6)0.0085 (6)0.0218 (7)
C50.0411 (6)0.0440 (7)0.0440 (6)0.0089 (5)0.0080 (5)0.0110 (5)
C80.0485 (7)0.0431 (7)0.0441 (6)0.0183 (5)−0.0014 (5)0.0092 (5)
C30.0550 (8)0.0542 (8)0.0479 (7)0.0200 (6)−0.0012 (6)0.0007 (6)
C130.0701 (9)0.0534 (8)0.0528 (8)0.0230 (7)0.0137 (7)0.0042 (6)
C20.0728 (10)0.0465 (8)0.0605 (8)0.0221 (7)0.0086 (7)0.0022 (6)
C10.0653 (9)0.0537 (8)0.0661 (9)0.0319 (7)0.0188 (7)0.0200 (7)
C120.0525 (8)0.0538 (8)0.0599 (8)−0.0008 (6)0.0093 (6)0.0155 (6)

Geometric parameters (Å, °)

O4—C101.3460 (15)C9—C81.4904 (17)
O4—C111.4434 (15)C6—C51.3753 (19)
F—C51.3529 (16)C6—C11.381 (2)
O3—C81.3457 (16)C6—H6A0.9300
O3—C111.4460 (15)C3—C21.380 (2)
O2—C101.1996 (15)C3—H3A0.9300
C10—C91.4826 (16)C13—H13A0.9600
O1—C81.1979 (16)C13—H13B0.9600
C4—C51.3843 (18)C13—H13C0.9600
C4—C31.3978 (19)C2—C11.379 (2)
C4—C71.4639 (17)C2—H2A0.9300
C11—C131.5018 (18)C1—H1A0.9300
C11—C121.5041 (19)C12—H12A0.9600
C7—C91.3385 (17)C12—H12B0.9600
C7—H7A0.9300C12—H12C0.9600
C10—O4—C11119.32 (9)C6—C5—C4123.07 (13)
C8—O3—C11118.75 (9)O1—C8—O3119.85 (12)
O2—C10—O4119.30 (11)O1—C8—C9124.13 (12)
O2—C10—C9124.62 (11)O3—C8—C9115.98 (11)
O4—C10—C9115.80 (10)C2—C3—C4121.18 (14)
C5—C4—C3116.79 (12)C2—C3—H3A119.4
C5—C4—C7124.51 (12)C4—C3—H3A119.4
C3—C4—C7118.56 (12)C11—C13—H13A109.5
O4—C11—O3109.41 (10)C11—C13—H13B109.5
O4—C11—C13106.34 (11)H13A—C13—H13B109.5
O3—C11—C13106.18 (11)C11—C13—H13C109.5
O4—C11—C12110.47 (11)H13A—C13—H13C109.5
O3—C11—C12110.71 (11)H13B—C13—H13C109.5
C13—C11—C12113.52 (12)C1—C2—C3119.93 (14)
C9—C7—C4130.10 (11)C1—C2—H2A120.0
C9—C7—H7A114.9C3—C2—H2A120.0
C4—C7—H7A114.9C2—C1—C6120.39 (13)
C7—C9—C10125.14 (11)C2—C1—H1A119.8
C7—C9—C8117.26 (11)C6—C1—H1A119.8
C10—C9—C8117.09 (10)C11—C12—H12A109.5
C5—C6—C1118.59 (13)C11—C12—H12B109.5
C5—C6—H6A120.7H12A—C12—H12B109.5
C1—C6—H6A120.7C11—C12—H12C109.5
F—C5—C6118.32 (12)H12A—C12—H12C109.5
F—C5—C4118.57 (12)H12B—C12—H12C109.5

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
C1—H1A···O1i0.932.423.343 (4)174
C7—H7A···O10.932.422.798 (2)104

Symmetry codes: (i) x−1, y+1, z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: LH2910).

References

  • Bruker (1997). SMART and SAINT Bruker AXS Inc., Madison, Wisconsin, USA.
  • Casadesus, M., Coogan, M. P. & Ooi, L. L. (2006). Org. Biomol. Chem.58, 3822–3830. [PubMed]
  • Kuhn, N., Al-Sheikh, A. & Steimann, M. (2003). Z. Naturforsch 58, 381–384.
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]

Articles from Acta Crystallographica Section E: Structure Reports Online are provided here courtesy of International Union of Crystallography