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Acta Crystallogr Sect E Struct Rep Online. 2009 April 1; 65(Pt 4): o762.
Published online 2009 March 14. doi:  10.1107/S1600536809008423
PMCID: PMC2968852

8-Chloro-4-cyclo­hexyl-2H-1,4-benzoxazin-3(4H)-one

Abstract

In the crystal structure of title compound, C14H16ClNO2, the cyclo­hexyl ring is in a chair conformation. The molecules are connected into centrosymmetric dimers via weak C—H(...)O hydrogen bonds.

Related literature

For related structures, see: Li et al. (2008 [triangle]); Zuo et al. (2008 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-65-0o762-scheme1.jpg

Experimental

Crystal data

  • C14H16ClNO2
  • M r = 265.73
  • Monoclinic, An external file that holds a picture, illustration, etc.
Object name is e-65-0o762-efi1.jpg
  • a = 9.0570 (8) Å
  • b = 5.7026 (5) Å
  • c = 25.289 (2) Å
  • β = 98.776 (1)°
  • V = 1290.8 (2) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.29 mm−1
  • T = 293 K
  • 0.12 × 0.10 × 0.06 mm

Data collection

  • Bruker SMART CCD area-detector diffractometer
  • Absorption correction: multi-scan (SADABS; Bruker, 2005 [triangle]) T min = 0.967, T max = 0.985
  • 6491 measured reflections
  • 2284 independent reflections
  • 1865 reflections with I > 2σ(I)
  • R int = 0.018

Refinement

  • R[F 2 > 2σ(F 2)] = 0.035
  • wR(F 2) = 0.094
  • S = 1.02
  • 2284 reflections
  • 163 parameters
  • H-atom parameters constrained
  • Δρmax = 0.15 e Å−3
  • Δρmin = −0.25 e Å−3

Data collection: SMART (Bruker, 2005 [triangle]); cell refinement: SAINT (Bruker, 2005 [triangle]); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: XP in SHELXTL (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXL97.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809008423/nc2137sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809008423/nc2137Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

This study was supported by the Key Program Projects of the Municipal Natural Science Foundation of Chongqing, China (grant No. CSTC, 2007AC1042)

supplementary crystallographic information

Comment

As part of our project on the study of the interactions between small molecules and proteins (Li et al.; 2008 and Zuo et al.; 2008), we report here the synthesis and crystal structure of the title compound.

In the crystal structure of title compound, C14H16ClNO2, the cyclohexyl ring is in a chair conformation. The molecules are connected via two weak C-H···O hydrogen bonds into dimers which are located on centres of inversion.

Experimental

To a solution of N-cyclohexyl-2-(2,3-dichlorophenoxy)acetamide(0.604 g, 2.0 mmol) in DMF (20 ml), caesium carbonate (0.787 g, 2.4 mmol) was added. The mixture was refluxed for 2 h. After completion of the reaction (by TLC monitoring), the DMF was removed under vacuum. Water (20 ml) was added into to obtain a turbid solution and it was extracted by ethyl acetate (20 ml x 4). The combined organic layer was washed by 1 mol/L of hydrochloric acid (10 ml x 3) and saturated sodium chloride solution (10 ml x 3), dried over MgSO~4~. And then the mixture was filtered and the filtrate obtained was concentrated under reduced pressure to obtain the corresponding crude product. The product was purified by column chromatography on silica gel using ethyl/acetate = 1/5 as eluent (yield 72%). Crystals suitable for X-ray diffraction were obtained by slow evaporation of a solutionof the solid dissolved in ethyl acetate/hexane at room temperature for 10 days.

Refinement

All H atoms were palced in calculated positions and refined as riding, with C—H = 0.93–0.97Å and with Uiso(H)=1.2Ueq(C).

Figures

Fig. 1.
The molecular structure of the title compound with labeling and displacement ellipsoids drawn at the 50% probability level.

Crystal data

C14H16ClNO2F(000) = 560
Mr = 265.73Dx = 1.367 Mg m3
Monoclinic, P21/nMo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ynCell parameters from 2520 reflections
a = 9.0570 (8) Åθ = 2.3–26.2°
b = 5.7026 (5) ŵ = 0.29 mm1
c = 25.289 (2) ÅT = 293 K
β = 98.776 (1)°Block, colorless
V = 1290.8 (2) Å30.12 × 0.10 × 0.06 mm
Z = 4

Data collection

Bruker SMART CCD area-detector diffractometer2284 independent reflections
Radiation source: fine-focus sealed tube1865 reflections with I > 2σ(I)
graphiteRint = 0.018
[var phi] and ω scansθmax = 25.1°, θmin = 2.3°
Absorption correction: multi-scan (SADABS; Bruker, 2005)h = −10→10
Tmin = 0.967, Tmax = 0.985k = −3→6
6491 measured reflectionsl = −30→29

Refinement

Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.035Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.094H-atom parameters constrained
S = 1.02w = 1/[σ2(Fo2) + (0.0412P)2 + 0.4617P] where P = (Fo2 + 2Fc2)/3
2284 reflections(Δ/σ)max < 0.001
163 parametersΔρmax = 0.15 e Å3
0 restraintsΔρmin = −0.24 e Å3

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
Cl1−0.15312 (6)0.41531 (10)0.22217 (2)0.06310 (19)
O1−0.02832 (15)0.3875 (2)0.12160 (5)0.0532 (3)
O20.13476 (15)0.2157 (3)0.01039 (5)0.0598 (4)
N10.18465 (15)0.0827 (3)0.09632 (5)0.0423 (4)
C1−0.02699 (18)0.2077 (3)0.20691 (7)0.0440 (4)
C20.02332 (18)0.2168 (3)0.15761 (6)0.0409 (4)
C30.12797 (18)0.0547 (3)0.14560 (6)0.0389 (4)
C40.17380 (19)−0.1228 (3)0.18194 (7)0.0447 (4)
H40.2398−0.23710.17360.054*
C50.1216 (2)−0.1303 (4)0.23061 (7)0.0500 (5)
H50.1542−0.24860.25500.060*
C60.0224 (2)0.0345 (4)0.24338 (7)0.0486 (5)
H6−0.01120.02940.27630.058*
C70.0994 (2)0.1974 (3)0.05491 (7)0.0459 (4)
C8−0.0428 (2)0.3028 (4)0.06762 (7)0.0556 (5)
H8A−0.07220.43150.04320.067*
H8B−0.12130.18550.06210.067*
C90.33367 (19)−0.0012 (3)0.08766 (7)0.0408 (4)
H90.35550.08330.05600.049*
C100.3391 (3)−0.2597 (4)0.07334 (8)0.0605 (6)
H10A0.2618−0.29450.04340.073*
H10B0.3211−0.35470.10350.073*
C110.4918 (3)−0.3181 (4)0.05863 (9)0.0836 (8)
H11A0.4973−0.48520.05210.100*
H11B0.5037−0.23700.02580.100*
C120.6170 (3)−0.2494 (5)0.10186 (10)0.0847 (8)
H12A0.7118−0.27960.08980.102*
H12B0.6126−0.34470.13330.102*
C130.6084 (2)0.0065 (5)0.11650 (10)0.0701 (6)
H13A0.62470.10240.08620.084*
H13B0.68680.04200.14600.084*
C140.45753 (19)0.0669 (3)0.13235 (7)0.0482 (5)
H14A0.4451−0.01640.16480.058*
H14B0.45270.23370.13930.058*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
Cl10.0551 (3)0.0751 (4)0.0607 (3)0.0114 (3)0.0140 (2)−0.0067 (3)
O10.0570 (8)0.0561 (8)0.0459 (7)0.0134 (6)0.0059 (6)0.0113 (6)
O20.0662 (9)0.0766 (10)0.0368 (7)0.0075 (7)0.0084 (6)0.0158 (7)
N10.0397 (8)0.0521 (9)0.0352 (7)0.0022 (7)0.0059 (6)0.0101 (6)
C10.0338 (9)0.0557 (11)0.0421 (9)−0.0043 (8)0.0048 (7)−0.0025 (8)
C20.0360 (9)0.0455 (10)0.0396 (9)−0.0031 (8)0.0008 (7)0.0052 (8)
C30.0348 (8)0.0466 (10)0.0344 (8)−0.0051 (7)0.0026 (7)0.0053 (7)
C40.0419 (9)0.0481 (11)0.0445 (9)0.0028 (8)0.0075 (8)0.0084 (8)
C50.0482 (10)0.0590 (12)0.0426 (10)−0.0023 (9)0.0070 (8)0.0165 (9)
C60.0434 (10)0.0650 (13)0.0385 (9)−0.0073 (9)0.0094 (8)0.0047 (9)
C70.0465 (10)0.0502 (11)0.0392 (10)−0.0027 (8)0.0005 (8)0.0090 (8)
C80.0501 (11)0.0736 (14)0.0413 (10)0.0074 (10)0.0009 (8)0.0161 (10)
C90.0457 (10)0.0435 (10)0.0344 (8)0.0037 (8)0.0097 (7)0.0025 (7)
C100.0896 (16)0.0463 (12)0.0438 (10)0.0013 (11)0.0047 (10)−0.0079 (9)
C110.143 (2)0.0577 (14)0.0608 (14)0.0345 (15)0.0488 (16)0.0026 (11)
C120.0815 (17)0.102 (2)0.0784 (16)0.0455 (16)0.0383 (14)0.0203 (15)
C130.0440 (11)0.0946 (18)0.0733 (14)0.0063 (12)0.0146 (10)0.0075 (13)
C140.0447 (10)0.0530 (12)0.0472 (10)−0.0001 (9)0.0082 (8)−0.0058 (9)

Geometric parameters (Å, °)

Cl1—C11.7292 (19)C8—H8B0.9700
O1—C21.366 (2)C9—C141.516 (2)
O1—C81.435 (2)C9—C101.521 (3)
O2—C71.221 (2)C9—H90.9800
N1—C71.369 (2)C10—C111.523 (3)
N1—C31.427 (2)C10—H10A0.9700
N1—C91.479 (2)C10—H10B0.9700
C1—C61.378 (3)C11—C121.502 (4)
C1—C21.392 (2)C11—H11A0.9700
C2—C31.390 (2)C11—H11B0.9700
C3—C41.388 (2)C12—C131.510 (4)
C4—C51.385 (2)C12—H12A0.9700
C4—H40.9300C12—H12B0.9700
C5—C61.372 (3)C13—C141.521 (3)
C5—H50.9300C13—H13A0.9700
C6—H60.9300C13—H13B0.9700
C7—C81.500 (3)C14—H14A0.9700
C8—H8A0.9700C14—H14B0.9700
C2—O1—C8111.50 (15)N1—C9—H9105.3
C7—N1—C3119.02 (14)C14—C9—H9105.3
C7—N1—C9117.53 (14)C10—C9—H9105.3
C3—N1—C9123.43 (13)C9—C10—C11109.46 (18)
C6—C1—C2120.58 (17)C9—C10—H10A109.8
C6—C1—Cl1119.96 (14)C11—C10—H10A109.8
C2—C1—Cl1119.46 (14)C9—C10—H10B109.8
O1—C2—C3120.24 (15)C11—C10—H10B109.8
O1—C2—C1119.88 (16)H10A—C10—H10B108.2
C3—C2—C1119.87 (16)C12—C11—C10112.22 (17)
C4—C3—C2119.04 (15)C12—C11—H11A109.2
C4—C3—N1123.27 (16)C10—C11—H11A109.2
C2—C3—N1117.69 (14)C12—C11—H11B109.2
C5—C4—C3120.20 (17)C10—C11—H11B109.2
C5—C4—H4119.9H11A—C11—H11B107.9
C3—C4—H4119.9C11—C12—C13111.6 (2)
C6—C5—C4120.82 (17)C11—C12—H12A109.3
C6—C5—H5119.6C13—C12—H12A109.3
C4—C5—H5119.6C11—C12—H12B109.3
C5—C6—C1119.38 (16)C13—C12—H12B109.3
C5—C6—H6120.3H12A—C12—H12B108.0
C1—C6—H6120.3C12—C13—C14111.4 (2)
O2—C7—N1123.31 (17)C12—C13—H13A109.3
O2—C7—C8121.21 (16)C14—C13—H13A109.3
N1—C7—C8115.47 (15)C12—C13—H13B109.3
O1—C8—C7112.45 (14)C14—C13—H13B109.3
O1—C8—H8A109.1H13A—C13—H13B108.0
C7—C8—H8A109.1C9—C14—C13109.76 (16)
O1—C8—H8B109.1C9—C14—H14A109.7
C7—C8—H8B109.1C13—C14—H14A109.7
H8A—C8—H8B107.8C9—C14—H14B109.7
N1—C9—C14113.26 (14)C13—C14—H14B109.7
N1—C9—C10114.32 (16)H14A—C14—H14B108.2
C14—C9—C10112.25 (15)
C8—O1—C2—C336.1 (2)C3—N1—C7—O2−175.04 (17)
C8—O1—C2—C1−145.10 (16)C9—N1—C7—O26.4 (3)
C6—C1—C2—O1179.06 (16)C3—N1—C7—C85.2 (2)
Cl1—C1—C2—O1−0.7 (2)C9—N1—C7—C8−173.32 (16)
C6—C1—C2—C3−2.1 (3)C2—O1—C8—C7−54.4 (2)
Cl1—C1—C2—C3178.15 (13)O2—C7—C8—O1−145.51 (18)
O1—C2—C3—C4−177.29 (15)N1—C7—C8—O134.2 (2)
C1—C2—C3—C43.9 (2)C7—N1—C9—C14130.77 (17)
O1—C2—C3—N13.6 (2)C3—N1—C9—C14−47.7 (2)
C1—C2—C3—N1−175.20 (15)C7—N1—C9—C10−98.95 (19)
C7—N1—C3—C4155.62 (17)C3—N1—C9—C1082.6 (2)
C9—N1—C3—C4−25.9 (3)N1—C9—C10—C11172.94 (15)
C7—N1—C3—C2−25.3 (2)C14—C9—C10—C11−56.3 (2)
C9—N1—C3—C2153.11 (16)C9—C10—C11—C1254.7 (2)
C2—C3—C4—C5−3.4 (3)C10—C11—C12—C13−55.0 (3)
N1—C3—C4—C5175.67 (16)C11—C12—C13—C1455.3 (3)
C3—C4—C5—C61.0 (3)N1—C9—C14—C13−171.56 (16)
C4—C5—C6—C10.8 (3)C10—C9—C14—C1357.1 (2)
C2—C1—C6—C5−0.3 (3)C12—C13—C14—C9−55.7 (2)
Cl1—C1—C6—C5179.49 (14)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
C8—H8A···O2i0.972.443.407 (3)174

Symmetry codes: (i) −x, −y+1, −z.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: NC2137).

References

  • Bruker (2005). SMART, SAINT and SADABS Bruker AXS Inc., Madison, Wisconsin, USA.
  • Li, Z.-B., Luo, Y.-H., Dong, W.-L., Li, J. & Zuo, H. (2008). Acta Cryst. E64, o1610. [PMC free article] [PubMed]
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Zuo, H., Meng, L., Ghate, M., Hwang, K. H., Cho, Y. K., Chandrasekhar, S., Reddy, C. R. & Shin, D. S. (2008). Tetrahedron Lett.49, 3827–3830.

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