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A subscription to Nucleic Acids Research comprises 22 issues. All prices include postage, and for subscribers outside the UK delivery is by Standard Air. Nucleic Acids Research operates a model of continuous online publication, more details of which can be found at www.nar.oxfordjournals.org
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|Cover: The structures of natural nucleic acid duplexes DNA (left) and RNA (center) compared to a modified nucleic acid helix (right): A ‘locked’ nucleic acid (LNA) duplex that consists exclusively of 2′-O-4′C-methylene-β-D-ribofuranose nucleotides. LNA substituted RNAs are known to possess enlarged thermostability, which renders LNAs as valuable tools for therapeutic and diagnostic applications. The crystal structure of the ‘all LNA’ duplex reveals a new type of geometry that differs significantly from any natural nucleic acid helix.|
|For further information, please see the article by Eichert et al. (Nucleic Acids Res., 2010, 38, 6729–6736).|