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The reference strain for Merlin UL146 sequence was input incorrectly. This does not change the conclusions of the paper but does alter slightly the percentage similarity and identity and their subsequent phylogenetic groupings. The authors apologize for this oversight.
Results, p. 89, 2nd column:
“The mature forms without the signal sequence and the reference sequences contain between 93 and 103 residues that show 5% identity (6 residues) and 8% similarity (9 residues) (Fig. 1). All sequences were assigned to 11 distinct vCXCL-1 clades (Fig. 2). The intravariability within each clade was less than 6%. The designated genotypic group numbers were assigned according to the 14 UL146 groups described by Dolan et al. (2004). No vCXCL-1 sequences were found in groups 3, 4, and 5.”
“If the most distant reference group is removed (NT from Group 4, for which we did not assign any samples), the number of 100% consensus residues increases from 6 to 11. This includes the CXC chemokine motif and the four cysteine residues. This implies that this isolate is a very distant cousin of other vCXCL-1s.”
Discussion, p. 92, 2nd column:
“Our results demonstrate that out of the 14 groups, 11 of the clades did not exhibit a definitive association between UL146 genotypes and symptoms.”
DOI of original article: 10.1016/j.virol.2008.05.002
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