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Malar J. 2010; 9(Suppl 2): O21.
Published online 2010 October 20. doi:  10.1186/1475-2875-9-S2-O21
PMCID: PMC2963229

Wild chimpanzees are infected with homologous types of human malaria

Background

Despite ongoing - and in some regions escalating - morbidity and mortality associated with malaria parasites, evolutionary epidemiology of Plasmodium is not well characterized. Recent studies using molecular approaches demonstrated that wild and captive gorillas and captive bonobos and chimpanzees are infected with P. falciparum and that these apes harbor parasites broadly related to P. falciparum[1]. Captive chimpanzees and bonobos had malaria parasites related to human P. ovale and P. malariae and various monkeys and one semi-wild chimpanzee had P. vivax[2]. It is not clear whether these apes harbor naturally these parasites or whether they are transmitted from humans. Most of the examined animals had close contact with humans, comparable studies in wild living apes are missing. We provide the first survey of Plasmodium diversity in wild chimpanzees living in an undisturbed tropical rainforest in Africa.

Methods

We examined tissue from 16 wild West African chimpanzees that lived in the Tai National Park, Ivory Coast, where human contact with animals is limited to researchers who access the territory only during the day. Samples were collected from animals that died primarily from anthrax or respiratory disease. Generic real time PCR assay was used to detect all known Plasmodium species.

Results

11/16 (68%) animals tested positive. Sequence analyses of cytB and 18S rRNA genes identified P. malariae, P. ovale, P. vivax, P. gaboni, P. reichenowi, P. billcollinsi and P. billbraii.

Discussion

Previous examination of the role of our closest phylogenetic relatives, the great apes, in the evolution and persistence of human malarias has been limited by a lack of data from wild ape populations. Interpretation of patterns of malaria infection in captive ape populations must consider ample opportunities for human to ape transmission, negating the opportunity to investigate the evolutionary origins and public health-related risks of these parasites. Our examination of malaria parasites in wild chimpanzees demonstrates that these apes are most likely naturally infected with Plasmodium species homologous to P. malariae, P. vivax and P. ovale as well as P. falciparum. Whether wild great apes are the origin of these malaria types requires further investigation but they may act as reservoir of infection. These results have important implications for global efforts underway to eradicate malaria in humans including vaccine development based on animal variants of human parasites.

References

  • Prugnolle F, Durand P, Neel C, Ollomo B, Ayala FJ, Arnathau C, Etienne L, Mpoudi-Ngole E, Nkoghe D, Leroy E, Delaporte E, Peeters M, Renaud F. African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum. Proc Natl Acad Sci USA. 2010;107:1458–63. doi: 10.1073/pnas.0914440107. [PubMed] [Cross Ref]
  • Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, Halbwax M, Fischer A, Krief JM, Kasenene JM, Crandfield M, Cornejo OE, Chavatte JM, Lin C, Letourneur F, Grüner AC, McCutchan TF, Rénia L, Snounou G. On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos. PLoS Pathog. 2010;6:e1000765. doi: 10.1371/journal.ppat.1000765. [PMC free article] [PubMed] [Cross Ref]

Articles from Malaria Journal are provided here courtesy of BioMed Central