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Acta Crystallogr Sect E Struct Rep Online. 2008 September 1; 64(Pt 9): o1767.
Published online 2008 August 16. doi:  10.1107/S1600536808025725
PMCID: PMC2960634

3-(2-Hydroxy­phen­yl)-5-(2-methoxy­phenyl)-1H-pyrazole

Abstract

The title compound, C16H14N2O2, was derived from 1-(2-hydroxy­phen­yl)-3-(2-methoxy­phen­yl)propane-1,3-dione. The mol­ecule is essentially planar (r.m.s. deviation for all non-H atoms = 0.089 Å). Two intra­molecular hydrogen bonds stabilize the mol­ecular conformation and one N—H(...)O hydrogen bond stabilizes the crystal structure.

Related literature

For related literature, see: Ahmad et al. (1990 [triangle], 1997 [triangle]); Ezava et al. (2005 [triangle]); Feierman & Cederbaum (1986 [triangle]); Sanz et al. (1998 [triangle]); Alcaraz et al. (1993 [triangle]); Hamper et al. (1997 [triangle]); Fujio (1999 [triangle]).

An external file that holds a picture, illustration, etc.
Object name is e-64-o1767-scheme1.jpg

Experimental

Crystal data

  • C16H14N2O2
  • M r = 266.29
  • Orthorhombic, An external file that holds a picture, illustration, etc.
Object name is e-64-o1767-efi1.jpg
  • a = 17.5626 (15) Å
  • b = 10.2239 (7) Å
  • c = 7.4513 (7) Å
  • V = 1337.94 (19) Å3
  • Z = 4
  • Mo Kα radiation
  • μ = 0.09 mm−1
  • T = 173 (2) K
  • 0.27 × 0.25 × 0.24 mm

Data collection

  • Stoe IPDSII two-circle diffractometer
  • Absorption correction: none
  • 10969 measured reflections
  • 1777 independent reflections
  • 1620 reflections with I > 2σ(I)
  • R int = 0.057

Refinement

  • R[F 2 > 2σ(F 2)] = 0.034
  • wR(F 2) = 0.090
  • S = 1.03
  • 1777 reflections
  • 191 parameters
  • 1 restraint
  • H atoms treated by a mixture of independent and constrained refinement
  • Δρmax = 0.18 e Å−3
  • Δρmin = −0.16 e Å−3

Data collection: X-AREA (Stoe & Cie, 2001 [triangle]); cell refinement: X-AREA; data reduction: X-AREA; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 [triangle]); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 [triangle]); molecular graphics: XP in SHELXTL-Plus (Sheldrick, 2008 [triangle]); software used to prepare material for publication: SHELXL97.

Table 1
Hydrogen-bond geometry (Å, °)

Supplementary Material

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536808025725/bx2163sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536808025725/bx2163Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

Acknowledgments

AH is grateful to the Higher Education Commission of Pakistan for a grant.

supplementary crystallographic information

Comment

3,5-substituted Pyrazoles are important class of compounds.These have been proven to be a selective inhibitor of COX in isoenzyme in human blood and are used for the development of anti-inflamatory drugs and analgesic medicines (Ezava et al., 2005). Disubstituted pyrazoles have been reported as an important intermediate in the synthesis of herbicides (US patent 5191087, 1993; US patent 5698708, 1997) and for the treatmet of pain and disorders such as Arthritis (US patent 5908857, 1999).Pyrazoles are inhibitors of alchol dehydrogenase and have been found to be effective inhibitors for the oxidation of ethanol by liver microsomes (Feierman & Cederbaum, 1986). 3,5-disubstituted pyrazoles are also uesd to form solid dinuclear complexes (Sanz et al., 1998). The molecule is essentially planar (r.m.s. deviation for all non-H atoms 0.089 Å). Two intramolecular hydrogen bonds stabilize the molecular conformation and one N—H···O hydrogen bond is stabilizing the crystal structure.

Experimental

1-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl) propane-1,3-dione was prepared by a modified Baker Venkataram rearrangement as reported earlier (Ahmad et al., 1997). Purification was carried out by recrystallization using absolute ethanol. 1-H-3(2-hydroxyphenyl)-5-(2-methoxyphenyl) pyrazole was synthesized by reacting hydrazine hydrate (0.5 g, 10 mmol) with 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl) propane-1,3-dione (2.7 g, 10 mmol) in 100 ml of absolute ethanol. The mixture was refluxed for seven hours. Solvent was removed under reduced pressure. Compound (II) was synthesized by adding 0.1 mole of phenyl hydrazine in 0.1 mole of compound (II) dissolved in 200 ml of absolute ethanol. The mixture was refluxed for 7 h. Solvent was removed under reduced pressure. Highly viscous residue was recrystallized using absolute ethanol. (Yield: 96%, m.p: 456k)

Refinement

In the absence of anomalous scatterers 1544 Friedel pairs were merged. H atoms were located in a difference map, but those bonded to C were geometrically positioned and refined using a riding model with fixed individual displacement parameters [U(H) = 1.2 Ueq(C) or U(H) = 1.5 Ueq(Cmethyl)] and with C—H = 0.95 Å or Cmethyl—H = 0.98 Å. The methyl group was allowed to rotate but not to tip. The H atoms bonded to N and O were freely refined.

Figures

Fig. 1.
Perspective view of the title compound with the atom numbering scheme; displacement ellipsoids are at the 50% probability level; H atoms are drawn as small spheres of arbitrary radii.

Crystal data

C16H14N2O2Dx = 1.322 Mg m3
Mr = 266.29Melting point: 456 K
Orthorhombic, Pna21Mo Kα radiation λ = 0.71073 Å
Hall symbol: P 2c -2nCell parameters from 11915 reflections
a = 17.5626 (15) Åθ = 3.4–29.6º
b = 10.2239 (7) ŵ = 0.09 mm1
c = 7.4513 (7) ÅT = 173 (2) K
V = 1337.94 (19) Å3Block, light yellow
Z = 40.27 × 0.25 × 0.24 mm
F000 = 560

Data collection

Stoe IPDSII two-circle diffractometer1620 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tubeRint = 0.057
Monochromator: graphiteθmax = 28.3º
T = 173(2) Kθmin = 3.6º
ω scansh = −20→23
Absorption correction: nonek = −11→13
10969 measured reflectionsl = −8→9
1777 independent reflections

Refinement

Refinement on F2Secondary atom site location: difference Fourier map
Least-squares matrix: fullHydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.034H atoms treated by a mixture of independent and constrained refinement
wR(F2) = 0.091  w = 1/[σ2(Fo2) + (0.0644P)2 + 0.0395P] where P = (Fo2 + 2Fc2)/3
S = 1.03(Δ/σ)max < 0.001
1777 reflectionsΔρmax = 0.18 e Å3
191 parametersΔρmin = −0.16 e Å3
1 restraintExtinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methodsExtinction coefficient: 0.049 (6)

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
O10.49830 (7)0.72482 (13)0.76358 (19)0.0401 (3)
O20.42612 (9)1.04511 (15)0.0584 (2)0.0507 (4)
H20.441 (2)0.992 (4)0.165 (6)0.093 (11)*
N10.44362 (8)0.80017 (15)0.4520 (2)0.0340 (3)
H10.4833 (15)0.825 (3)0.525 (4)0.058 (7)*
N20.43083 (8)0.86611 (15)0.2984 (2)0.0369 (3)
C10.39489 (9)0.69783 (15)0.4736 (2)0.0289 (3)
C20.34823 (9)0.69776 (15)0.3232 (2)0.0306 (3)
H2A0.30830.63810.29680.037*
C30.37225 (9)0.80434 (16)0.2179 (2)0.0304 (3)
C110.39509 (9)0.61110 (16)0.6314 (2)0.0306 (3)
C120.44651 (9)0.62379 (17)0.7757 (2)0.0339 (3)
C130.44373 (11)0.5373 (2)0.9203 (3)0.0425 (4)
H130.47880.54611.01650.051*
C140.38945 (12)0.4381 (2)0.9235 (3)0.0461 (5)
H140.38820.37861.02140.055*
C150.33733 (11)0.42539 (19)0.7852 (3)0.0437 (4)
H150.29980.35850.78910.052*
C160.34031 (10)0.51098 (17)0.6410 (3)0.0353 (4)
H160.30450.50180.54630.042*
C170.55036 (12)0.7438 (3)0.9090 (3)0.0520 (5)
H17A0.58250.66600.92220.078*
H17B0.52180.75831.02020.078*
H17C0.58250.82010.88430.078*
C310.34524 (9)0.85273 (17)0.0429 (2)0.0314 (3)
C320.37398 (10)0.96997 (18)−0.0313 (3)0.0367 (4)
C330.34958 (11)1.0130 (2)−0.1993 (3)0.0438 (4)
H330.36931.0919−0.24820.053*
C340.29652 (12)0.9407 (2)−0.2952 (3)0.0437 (4)
H340.28050.9700−0.41020.052*
C350.26648 (11)0.82574 (19)−0.2245 (3)0.0417 (4)
H350.22970.7772−0.29000.050*
C360.29090 (10)0.78266 (17)−0.0569 (2)0.0354 (4)
H360.27040.7041−0.00890.042*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
O10.0371 (6)0.0507 (8)0.0327 (6)−0.0037 (5)−0.0084 (5)0.0025 (6)
O20.0531 (8)0.0541 (8)0.0448 (8)−0.0219 (7)−0.0050 (7)0.0142 (7)
N10.0363 (7)0.0385 (7)0.0273 (7)−0.0070 (6)−0.0052 (6)0.0026 (6)
N20.0390 (7)0.0402 (7)0.0314 (8)−0.0087 (6)−0.0060 (6)0.0038 (6)
C10.0298 (7)0.0302 (7)0.0268 (8)0.0005 (6)−0.0005 (6)−0.0037 (6)
C20.0306 (7)0.0329 (7)0.0283 (8)−0.0029 (6)−0.0024 (6)−0.0014 (6)
C30.0304 (7)0.0336 (8)0.0271 (8)−0.0008 (6)−0.0013 (6)−0.0018 (6)
C110.0325 (7)0.0330 (7)0.0263 (7)0.0057 (6)0.0020 (6)−0.0017 (6)
C120.0325 (7)0.0394 (8)0.0299 (8)0.0063 (6)0.0008 (6)−0.0018 (7)
C130.0413 (9)0.0537 (11)0.0326 (9)0.0113 (8)−0.0018 (7)0.0071 (8)
C140.0493 (10)0.0513 (11)0.0378 (10)0.0074 (8)0.0033 (8)0.0156 (9)
C150.0476 (9)0.0410 (9)0.0426 (11)−0.0005 (7)0.0046 (8)0.0065 (8)
C160.0389 (8)0.0333 (8)0.0337 (9)0.0004 (7)0.0005 (7)−0.0010 (7)
C170.0431 (10)0.0746 (14)0.0384 (11)−0.0055 (10)−0.0137 (8)0.0031 (10)
C310.0314 (7)0.0365 (8)0.0263 (8)0.0041 (6)0.0016 (6)−0.0006 (6)
C320.0357 (8)0.0434 (9)0.0310 (9)−0.0011 (7)0.0048 (7)0.0015 (7)
C330.0483 (10)0.0488 (10)0.0342 (10)0.0069 (8)0.0084 (8)0.0103 (8)
C340.0510 (10)0.0530 (10)0.0271 (8)0.0189 (9)−0.0001 (7)0.0001 (8)
C350.0464 (9)0.0464 (9)0.0324 (9)0.0122 (7)−0.0083 (7)−0.0067 (8)
C360.0384 (8)0.0370 (8)0.0307 (8)0.0036 (7)−0.0040 (7)−0.0037 (7)

Geometric parameters (Å, °)

O1—C121.379 (2)C14—C151.384 (3)
O1—C171.431 (2)C14—H140.9500
O2—C321.369 (2)C15—C161.387 (3)
O2—H20.99 (4)C15—H150.9500
N1—N21.347 (2)C16—H160.9500
N1—C11.361 (2)C17—H17A0.9800
N1—H10.92 (3)C17—H17B0.9800
N2—C31.348 (2)C17—H17C0.9800
C1—C21.388 (2)C31—C361.406 (2)
C1—C111.473 (2)C31—C321.413 (2)
C2—C31.408 (2)C32—C331.395 (3)
C2—H2A0.9500C33—C341.387 (3)
C3—C311.473 (2)C33—H330.9500
C11—C161.407 (2)C34—C351.392 (3)
C11—C121.410 (2)C34—H340.9500
C12—C131.394 (3)C35—C361.392 (3)
C13—C141.392 (3)C35—H350.9500
C13—H130.9500C36—H360.9500
C12—O1—C17118.24 (16)C16—C15—H15120.2
C32—O2—H2105 (2)C15—C16—C11121.61 (18)
N2—N1—C1112.35 (14)C15—C16—H16119.2
N2—N1—H1119.2 (18)C11—C16—H16119.2
C1—N1—H1128.3 (18)O1—C17—H17A109.5
N1—N2—C3105.72 (14)O1—C17—H17B109.5
N1—C1—C2106.03 (15)H17A—C17—H17B109.5
N1—C1—C11123.76 (15)O1—C17—H17C109.5
C2—C1—C11130.20 (14)H17A—C17—H17C109.5
C1—C2—C3105.82 (14)H17B—C17—H17C109.5
C1—C2—H2A127.1C36—C31—C32117.91 (16)
C3—C2—H2A127.1C36—C31—C3121.03 (15)
N2—C3—C2110.08 (15)C32—C31—C3121.05 (16)
N2—C3—C31118.85 (15)O2—C32—C33117.80 (17)
C2—C3—C31131.07 (15)O2—C32—C31121.61 (17)
C16—C11—C12117.79 (16)C33—C32—C31120.59 (18)
C16—C11—C1118.49 (15)C34—C33—C32120.02 (18)
C12—C11—C1123.71 (15)C34—C33—H33120.0
O1—C12—C13123.28 (17)C32—C33—H33120.0
O1—C12—C11116.16 (15)C33—C34—C35120.64 (18)
C13—C12—C11120.56 (17)C33—C34—H34119.7
C14—C13—C12119.95 (18)C35—C34—H34119.7
C14—C13—H13120.0C36—C35—C34119.34 (18)
C12—C13—H13120.0C36—C35—H35120.3
C15—C14—C13120.55 (18)C34—C35—H35120.3
C15—C14—H14119.7C35—C36—C31121.49 (17)
C13—C14—H14119.7C35—C36—H36119.3
C14—C15—C16119.51 (18)C31—C36—H36119.3
C14—C15—H15120.2
C1—N1—N2—C3−0.2 (2)C12—C13—C14—C15−0.9 (3)
N2—N1—C1—C20.46 (19)C13—C14—C15—C161.2 (3)
N2—N1—C1—C11−178.61 (14)C14—C15—C16—C11−0.1 (3)
N1—C1—C2—C3−0.50 (18)C12—C11—C16—C15−1.2 (3)
C11—C1—C2—C3178.48 (16)C1—C11—C16—C15179.75 (16)
N1—N2—C3—C2−0.1 (2)N2—C3—C31—C36172.07 (16)
N1—N2—C3—C31−179.01 (14)C2—C3—C31—C36−6.5 (3)
C1—C2—C3—N20.4 (2)N2—C3—C31—C32−7.0 (2)
C1—C2—C3—C31179.10 (16)C2—C3—C31—C32174.43 (18)
N1—C1—C11—C16178.05 (15)C36—C31—C32—O2178.95 (17)
C2—C1—C11—C16−0.8 (3)C3—C31—C32—O2−2.0 (3)
N1—C1—C11—C12−0.9 (2)C36—C31—C32—C33−0.8 (2)
C2—C1—C11—C12−179.75 (17)C3—C31—C32—C33178.21 (15)
C17—O1—C12—C13−1.8 (3)O2—C32—C33—C34−179.68 (18)
C17—O1—C12—C11178.37 (16)C31—C32—C33—C340.1 (3)
C16—C11—C12—O1−178.60 (15)C32—C33—C34—C350.7 (3)
C1—C11—C12—O10.4 (2)C33—C34—C35—C36−0.8 (3)
C16—C11—C12—C131.5 (2)C34—C35—C36—C310.1 (3)
C1—C11—C12—C13−179.50 (16)C32—C31—C36—C350.8 (2)
O1—C12—C13—C14179.62 (17)C3—C31—C36—C35−178.30 (16)
C11—C12—C13—C14−0.5 (3)

Hydrogen-bond geometry (Å, °)

D—H···AD—HH···AD···AD—H···A
O2—H2···N20.99 (4)1.64 (4)2.560 (2)152 (3)
N1—H1···O10.92 (3)2.07 (3)2.628 (2)118 (2)
N1—H1···O2i0.92 (3)2.09 (3)2.892 (2)146 (3)

Symmetry codes: (i) −x+1, −y+2, z+1/2.

Footnotes

Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: BX2163).

References

  • Ahmad, R., Malik, M. A. & Zia-ul-Haq, M. (1990). J. Chem. Soc. Pak.12, 352–354.
  • Ahmad, R., Malik, M. A., Zia-ul-Haq, M., Duddeek, H., Stefaniak, L. & Kowski, J. S. (1997). Monatsh. Chem.128, 633-640.
  • Alcaraz, J. M., Lecacheur, M. & Robin,Y. (1993) US Patent 5 191 087.
  • Ezava, M., Garvey, D. S., Janero, D. R., Khanapure, S. P., Letts, L. G., Martino, A., Ranatunge, R. R., Schwalb, D. J. & Young, D. V. (2005). Lett. Drug Des. Discov.2, 40-43.
  • Feierman, D. E. & Cederbaum, A. I. (1986). Biochem. J.239, 671–677. [PubMed]
  • Hamper, B. C., Mao, M. K. & Phillips, W. G. (1997). US Patent 5 698 708.
  • Sanz, A. M., Navarro, P., Gomez-Contreras, F., Pardo, M., Pepe, G. & Samat, A. (1998). Can. J. Chem.76, 1174–1179.
  • Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. [PubMed]
  • Stoe & Cie (2001). X-AREA Stoe & Cie, Darmstadt, Germany.
  • Suzuki, F. (1999). US Patent 5 908 857.

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