The title compound, C25H20N2O4, is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetralone unit (E and D), a 4-nitrophenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclohexenone ring (D) has an intermediate sofa/half-chair conformation. The aromatic ring of the 4-nitrophenyl substituent (B) is inclined at an angle of 78.97 (10)° to the phenyl ring (C). The rigid pharmacophore site, Osp 2—C—C—Osp 3, is characterized by an OO distance of 3.113 (2) Å and an O—C—C—O torsion angle of 97.8 (2)°. In the crystal structure, molecules are linked by C—HO contacts.