PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of ijpsychHomeCurrent issueInstructionsSubmit article
 
Indian J Psychiatry. 2002 Jul-Sep; 44(3): 260–265.
PMCID: PMC2954397

A COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF MIRTAZAPINE VERSUS AMITRIPTYLINE IN THE TREATMENT OF MAJOR DEPRESSION

Abstract

A clinical trial was undertaken to evaluate the Anti depressant efficacy of Newer Antidepressant Mirtazapine in the treatment of major Depression in 39 patients in an O.P.D. setup. In addition to this clinical acceptability and safety profile of Mirtazapine as compared to that of Amitriptyline was also assessed. Mitazapine usually described as Noradrenergic and specific serotonergic Anti depressant (NaSSA). Patients aged 18-65 years who fulfilled the diagnostic criteria for a single or recurrent major Depressive disorder (as defined by DSM IV) for a minimum of 2 weeks were enrolled at our study centre. Patient assessment were conducted at screening, baseline, end of week 1, week 2, week 3, week 4, week 5 & end of week 6 for the efficacy & safety Parameters; HRSD, CGI, Adverse event follow up, BP & Pulse. Three level statistical analysis were performed on all efficacy measures including ANOVA (An Analysis of variance). The result indicates that mirtazapine is effective in the treatment of major depression at the dosages range of 15-45 mg/day and it has efficacy equivalent to that of the standard TCA Amitriptyline, albeit, with a substantially better tolerability profile.

Keywords: Mirtazapine, NaSSA, Reccurrent major Depressive Disorder, Efficacy, Tolerability Profile

Full Text

The Full Text of this article is available as a PDF (249K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bremner JD. A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression. J Clin Psychiatry. 1995 Nov;56(11):519–525. [PubMed]
  • Claghorn JL, Lesem MD. A double-blind placebo-controlled study of Org 3770 in depressed outpatients. J Affect Disord. 1995 Jun 8;34(3):165–171. [PubMed]
  • Montgomery SA. Safety of mirtazapine: a review. Int Clin Psychopharmacol. 1995 Dec;10 (Suppl 4):37–45. [PubMed]

Articles from Indian Journal of Psychiatry are provided here courtesy of Wolters Kluwer -- Medknow Publications