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To determine whether postdating delayed antibiotic prescriptions results in a further decrease (over usual delayed pescriptions) in antibiotic use.
Randomized controlled trial.
A small rural town in Newfoundland and Labrador.
A total of 149 consecutive adult primary care patients who presented with acute upper respiratory tract infections.
Delayed prescriptions for patients who might require antibiotics were randomly dated either the day of the office visit (ie, the usual group) or 2 days later (ie, the postdated group).
Whether or not the prescriptions were filled and the time it took for the patients to fill the prescriptions were noted by the 4 local pharmacies and relayed to the investigators.
In total, 149 delayed antibiotic prescriptions were written, 1 per patient. Of the 74 usual delayed prescriptions given out, 32 (43.2%) were filled; of the 75 postdated delayed prescriptions given out, 33 (44.0%) were filled. Sixteen patients from each group filled their delayed prescriptions earlier than the recommended 48 hours. Statistical analyses—χ2 tests to compare the rates of antibiotic use between the 2 groups and t tests to compare the mean time to fill the prescription between the 2 groups—indicated that these results were not significant (P > .05).
Although delayed prescriptions reduce the rate of antibiotic use, postdating the delayed prescription does not seem to lead to further reduction in use.
Déterminer si le fait de postdater les prescriptions d’antibiotiques différées entraîne une plus grande réduction de l’utilisation des antibiotiques que les prescriptions différées habituelles..
Essai randomisé avec témoins.
Une petite localité rurale de Terre-Neuve et Labrador.
Un total de 149 patients adultes consécutifs en médecine primaire consultant pour une infection des voies respiratoires aigüe.
De façon aléatoire, les prescriptions différées pour les patients susceptibles de nécessiter ultérieurement des antibiotiques ont été préparées en date de la journée de la consultation (i. e. mode habituel) ou pour 2 jours plus tard (groupe postdaté).
Les 4 pharmacies locales ont noté si les prescriptions ont été remplies ou non, et le temps qu’il a fallu aux patients pour les pour la faire remplir. Ces renseignements ont été transmis aux chercheurs.
On a fait un total de 149 prescriptions différées d’antibiotiques, une par patient. Sur les 74 prescriptions différées habituelles, 32 (43,2 %) ont été remplies; sur les 75 prescriptions différées postdatées, 33 (44 %) ont été remplies. Seize patients de chacun des groupes ont fait remplir leur prescription avant le délai recommandé de 48 heures. L’analyse statistique – comparaison par tests de χ2 des taux d’utilisation d’antibiotiques entre les 2 groupes et par tests de t pour les moyennes des délais pour remplir les prescriptions - indiquait que ces résultats n’étaient pas significatifs (P > .05).
Même si les prescriptions différées diminuent le taux de consommation d’antibiotiques, le fait de postdater ces prescriptions ne semble pas diminuer davantage cette utilisation.
Inappropriate prescribing of antibiotics for acute respiratory tract infections (which are usually caused by viruses) is widespread.1–3 It is well known that inappropriate overuse of antibiotics is partly responsible for antibiotic resistance.4 Family doctors are aware that antibiotics are not much use for patients with these infections, yet many continue to prescribe them “against the evidence.”5–7
Some family doctors have adopted the use of delayed antibiotic prescriptions for common respiratory infections. A delayed prescription is given to the patient at the time of the office visit and can be filled and the antibiotics used if the illness symptoms do not improve within a mutually agreed upon time—usually about 48 hours. The first evidence on the benefits of delayed prescriptions came from a randomized controlled trial published in 1997, in which Little and his colleagues in Southampton, England, found that antibiotic prescriptions with a 3-day delay period for patients with acute sore throat reduced the number of patients actually taking the antibiotics from 99% to 31%.8 Since then there have been 6 other trials on the use of delayed prescriptions, all of which have shown reduction in antibiotic use.9–14
There is, therefore, strong evidence that the use of delayed antibiotic prescriptions results in a large drop in antibiotic use. We wondered whether postdating the prescription so that the patient was, in theory, unable to use it immediately might cause a further reduction in antibiotic use. We designed a trial to compare the antibiotic prescription uptake rates of delayed prescriptions that could be filled immediately with the uptake rates of postdated prescriptions that could only be used after a certain time. As nurse practitioners (NPs) are now commonly the first point of contact in acute primary care, we involved them as well as FPs in our study.
This was a randomized controlled trial, approved by Memorial University of Newfoundland’s Human Investigations Committee (No. 06.049).
Six FPs and 2 NPs in a small community in Newfoundland and Labrador were asked to recruit consecutive adult patients (aged 18 years or older) with acute upper respiratory tract infections for whom the clinicians thought antibiotic treatment might not be necessary. After a standardized explanation of the likely viral, benign, and self-limiting nature of the illness (Box 1), the patient was randomly given a delayed prescription dated for either the day of the office visit (ie, the usual prescription), or 2 days later (ie, the postdated prescription). In each case the patient was asked to use the prescription only if symptoms had not improved or had worsened after 2 days. Clinicians were asked to follow their usual practices regarding symptomatic treatment. Patients with concerns were asked to call their respective clinicians.
I think you are suffering from [provide diagnosis]. This condition is usually caused by a virus and tends to get better by itself, without any curative treatment. All that should be necessary is treatment to relieve your symptoms—[insert suggestions]—and the illness will likely improve within a few days.
Although most infections are caused by viruses, and antibiotics do not help with recovery, a small number of infections like yours can be caused by bacteria; we treat these infections with antibiotics. Unfortunately, we cannot tell by examining you whether you have the usual virus-type infection or whether you are one of the few who have a bacterial infection. We now prescribe fewer antibiotics than we used to, not only because they don’t cure most infections like yours, but because they can cause unpleasant side effects like diarrhea, vomiting, and skin rashes.
Here is what I suggest: I shall give you a prescription for an antibiotic. I think that you should not fill this prescription now, but wait for 2 days to see how your illness progresses. If, after 2 days, your symptoms are getting worse or there is no improvement, you can take the prescription to the pharmacist and start taking the antibiotic. If, at any time, new symptoms develop, or you are worried about your illness, you can call me or come to see me again.
Do you have questions about what we are doing?
When the clinician had determined whether a patient was eligible for the study, a blank envelope containing either a usual or a postdated delayed prescription was opened in front of the patient. By block randomization, each FP and NP was given an equal number of both prescriptions.
The delayed prescriptions were on specially marked pads so that they could easily be identified by local pharmacists. All 4 pharmacies in the study area took part. It was unlikely participants went to a pharmacy outside the study area, as the next closest town was 200 km away. During the period of the study, the pharmacies were regularly contacted by the research assistant to determine how many study prescriptions had been filled and on what date each prescription was filled. If a patient filled a delayed prescription before the due date, the pharmacist was asked to note in a logbook the reason given by the patient.
Our null hypothesis was that there would be no difference in antibiotic prescription consumption rates between the usual and postdated delayed prescription groups. If the usual prescription uptake is 85%, a sample size of 150 (75 in each arm of the study) is sufficient to detect a 20% difference in rates (which we judged to be clinically significant) at α = .05 and β = .2.15 Proportions were compared using the χ2 test, and means were compared using the t test.
Six FPs and 2 NPs took part in the study. Table 1 shows the patients’ conditions as diagnosed by the clinicians writing the delayed antibiotic prescriptions. The most common condition was upper respiratory tract infection, followed by sinusitis, bronchitis, and pharyngitis. The range of illnesses was similar in both the usual and the postdated groups.
The clinicians wrote 149 delayed antibiotic prescriptions, of which 74 were usual and 75 were postdated. In total, 65 of 149 prescriptions were filled (43.6%): 32 (43.2%) usual prescriptions and 33 (44.0%) postdated prescriptions (not significant [NS]; χ2 = 0.009, P = .924). Figure 1 represents a flow chart of the design and outcomes of the trial.
Of the 65 prescriptions filled, 32 were filled within 2 days of being written—16 usual and 16 postdated (NS; χ2 = 0.001, P = .975). The time it took to fill the other 33 prescriptions ranged from 3 to 19 days, with a mean of 6.1 days in the usual group and a mean of 6.5 days in the postdated group (NS; t = 0.041, P = .968).
Table 2 indicates the reasons given to the pharmacist by patients who filled their delayed prescriptions early (ie, within the 2-day delay period). The most common reason was that the patient was “unwell” or “getting worse”; in 7 cases the patients were “adamant” that they wanted to fill the prescriptions immediately, and in 4 cases the patients were “leaving town.”
We found, as did other studies,8–14 that issuing delayed prescriptions results in a large drop in antibiotic use. In our study, total antibiotic use was only 43%, more than necessary in the treatment of predominantly viral illnesses, but much lower than typical rates of antibiotic use in the developed world in general5–7 and in Newfoundland specifically.16 Other studies have found that delayed prescriptions result in rates of antibiotic use from 24%10 to 65%9; ours was in the middle of that range. We realize that a short study like this will not affect clinician prescribing habits; however, a British trial is currently evaluating a complex multifaceted intervention to reduce the rates of inappropriate antibiotic prescribing in general practice.17
An article from the Cochrane Database of Systematic Reviews, which looked at the effects of delayed antibiotics on symptoms and complications of respiratory infections, found that there was no difference for most symptom measures between using immediate and delayed antibiotics for symptoms on day 1 and day 7.18 Of the 6 studies that reported fever, 3 found increased fever in the delayed antibiotic group. Another study found that in children with acute otitis media, pain and malaise severity scores favoured the immediate prescription group.9 Overall, however, there was no danger in delaying antibiotic use.
We found that postdating the delayed antibiotic prescription had no effect on either the number of prescriptions filled or the time it took for patients to get their antibiotics from the pharmacist. Although both patients and pharmacists knew that postdated prescriptions should not be filled until their due date, equal proportions of usual and postdated delayed prescriptions were filled on the day of the office visit or the following day (in each group, about half of the patients who filled their prescriptions filled them earlier than the clinicians had suggested, for a variety of reasons).
Both clinicians and patients knew they were participating in a study and might have been subject to the Hawthorne effect (ie, a form of reactivity in which people improve or modify an aspect of their behaviour when they know they are being studied). Also, the block randomization process gave clinicians an equal number of usual and postdated prescriptions; as they reached the end of their allotted prescriptions, clinicians might have known what the remaining prescriptions were, introducing possible bias.
We believe our study has confirmed that the use of delayed prescriptions results in a large drop in antibiotic use by adult patients with acute respiratory infections. We also think that physicians need not worry overmuch that patients will rush out and fill delayed prescriptions at once; it appears that only about 1 in 5 will do so, regardless of whether or not the prescription is postdated.
This article is eligible for Mainpro-M1 credits. To earn credits, go to www.cfp.ca and click on the Mainpro link.
Cet article donne droit à des crédits Mainpro-M1. Pour obtenir des crédits, allez à www.cfp.ca et cliquez sur le lien vers Mainpro.
This article has been peer reviewed.
Cet article a fait l’objet d’une révision par des pairs.
Dr Worrall, Ms Kettle, Dr Graham, and Dr Hutchinson all contributed to the concept and design of the study; data gathering, analysis, and interpretation; and preparing the manuscript for submission.